◀ Back to TNF

IL2 — TNF

Text-mined interactions from Literome

Liu et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 1997 (Yang Deficiency) : Hemorheological indexes, brain noradrenaline ( NE ), adrenocorticotropine ( ACTH ), beta endorphin, cortisol, estradiol, testosterone, interleukin-II (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen 's lymphocyte transformation and induction of IL-2 and the activity of natural killer cells ( NKC )
Takayama et al., J Invest Dermatol 1999 : Both GM-CSF and TNF-alpha induced the migration of human Langerhans cells in vitro, whereas IL-1beta, IL-2 , IL-10, IL-12, and IFN-gamma had no effect on Langerhans cell migration
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Xiao et al., Hua Xi Yi Ke Da Xue Xue Bao 1998 (Rheumatic Heart Disease) : As compared with pre-operative values, IL-2 levels in both groups decreased significantly ( P < 0.05 ), and the levels of sIL-2R, IL-6, TNF-alpha , and IL-10 in both groups increased significantly at multiple time points post-operative ( P < 0.01 ). All the values of cytokines returned to pre-operative levels at 7th post-operative day. Although there were no pre-operative differences in these cytokines between the two groups ( P > 0.05 ), the post-operative changes of cytokines in study group was more obvious than that in control group ( P < 0.01 )
Dmoszyńska et al., Leukemia & lymphoma 1999 (Hematologic Neoplasms...) : Our results indicated that IL-2 given subcutaneously at a low dose of 100 microg/day for 3 weeks induced IFN-gamma and TNF-alpha in plasma ( measured 24 hrs after the last dose of IL-2 ) and affected the ability of blood leukocytes to produce cytokines
Bosco et al., J Immunol 2000 (Inflammation) : Furthermore, HA markedly suppressed the ability of IL-2 to induce IL-1 beta, TNF-alpha , IL-6, and IL-8 mRNA expression and protein secretion by monocytes
Maekawa et al., Inflamm Res 2000 (Liver Neoplasms, Experimental) : Moreover, LPS- or IL-2-stimulation increased the levels of TNF-alpha and NOx in the supernatants of AH-130 cell and macrophage co-culture, although LPS and IL-2 did not induce TNF-alpha and NOx production by AH-130 cells incubated without macrophages
Reddy et al., Int Immunol 2001 : IL-2 induced tumor necrosis factor (TNF)-beta expression : further analysis in the IL-2 knockout model, and comparison with TNF-alpha, lymphotoxin-beta, TNFR1 and TNFR2 modulation
Ghigo et al., Infect Immun 2001 (Endocarditis, Bacterial...) : First, interleukin-10 suppressed C. burnetii stimulated production of TNF
Kelley et al., Lipids 2001 : CLA supplementation did not alter the in vitro secretion of prostaglandin E2, leukotriene B4, interleukin-1beta (IL-1beta), or tumor necrosis factor alpha (TNFalpha) by PBMC simulated with lipopolysaccharide, and the secretion of IL-2 by PBMC stimulated with phytohemagglutinin
Konstantinova et al., Acta Astronaut 1995 : However, the activity of the production of TNF in 48-hour PHA-cultures of lymphocytes was unchanged and the biological activity of IL-2 was not reduced
Choi et al., Immunopharmacol Immunotoxicol 2002 : YH-Tang significantly inhibited interleukin (IL)-1, IL-4, IL-6 and tumor necrosis factor-alpha (TNF-alpha) secretion in astrocytes stimulated with SP and LPS, but did not inhibit interferon-y ( IFN-gamma ) and IL-2 secretion significantly
Wigmore et al., Clin Immunol 2002 (Gastrointestinal Neoplasms...) : The effect of IL-2 on the production of tumour necrosis factor-alpha (TNF) and interleukin-6 (IL-6) by PBMCs isolated from patients with gastrointestinal cancer, multiple organ failure, and healthy controls was also studied ... IL-2 had no effect on IL-6 or TNF production by PBMCs isolated from any group in the presence or absence of bacterial lipopolysaccharide (LPS)
Monsalve-De Castillo et al., Clin Diagn Lab Immunol 2002 (Hepatitis B) : During the acute phase, IFN-gamma and TNF-alpha induced increases in IL-2 , sIL-2R, IL-10, and sCD30 levels in serum, which allowed the development of immunity characterized by the nonreactivity of the HBV surface antigen, the onset of antibodies to the HBV surface antigen ( anti-HBs ), and normal alanine aminotransferase levels during the convalescent phase
Werth et al., J Invest Dermatol 2003 : Although interleukin-12 is considered to act primarily on lymphocytes, provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha, we hypothesized that interleukin-12 might also affect tumor necrosis factor alpha secretion from skin cells ... Remarkably, the exogenous interleukin-12 totally blocked ultraviolet-B induced tumor necrosis factor alpha production ... Thus, interleukin-12 strongly inhibits tumor necrosis factor alpha production by noninflammatory skin cells, mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter
Lin et al., Crit Care Med 2003 (Hyperoxia) : Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 release
Dalhoff et al., Lancet Infect Dis 2003 : In general, most fluoroquinolone derivatives superinduce in-vitro interleukin 2 synthesis but inhibit synthesis of interleukin 1 and tumour necrosis factor (TNF)alpha ; furthermore, they enhance significantly the synthesis of colony stimulating factors (CSF)
Jana et al., J Neurochem 2003 : Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
Maeda et al., J Invest Dermatol 2003 : Among T helper 1 cytokines, interleukin-4 mediated suppression of tumor necrosis factor-alpha was not affected by terfenadine, which, however, markedly restored mRNA expression of interferon-gamma or interleukin-2
Lorré et al., Eur Cytokine Netw 1992 : Interleukin-2 induces tumor necrosis factor-alpha production by activated human T cells via a cyclosporin-sensitive pathway ... Anti-CD3 induced TNF-alpha production could be inhibited by blocking the IL-2R with a combination of anti-Tac and Mik beta 1 ( mAbs against the p55 and p75 chain of the IL-2R respectively ) thus indicating an essential role of IL-2 in TNF-alpha induction
Limb et al., Immunology 1992 : The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by interleukin-2 (IL-2), TNF-alpha and TNF-beta, and that of CD11b, CD11c and CD18 was increased by IL-2 , IL-4, TNF-alpha and TNF-beta
Naume et al., J Immunol 1992 : Time course of the IL-2 induced TNF production revealed an initial TNF-alpha production, whereas significant levels of TNF-beta were detected after 72 h
Lander et al., Cell Immunol 1992 : AG126 and AG183 enhanced TNF-alpha secretion and this effect was more prominent in the presence of IL-2
Innins et al., Cytokine 1992 : T-LAK cells grown from days 7 to 10 in the presence of IL-2 and rabbit anti-TNF were significantly growth inhibited ( up to 23 % )
Tada et al., Hokkaido Igaku Zasshi 1992 (Brain Neoplasms...) : TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase, interleukin (IL)-6 and IL-8 by glioblastoma cells
Ayroldi et al., Nat Immun 1992 : The data indicate that IFN-gamma and TNF-alpha production may be required for IL-2 induction of NK activity, and are consistent with the hypothesis that NK generation involves collaboration between IL-2 and other bone marrow microenvironmental growth factors
Soboslay et al., Clin Exp Immunol 1992 (Dermatitis...) : Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta, tumour necrosis factor-alpha (TNF-alpha) and IL-6 in response to mitogenic stimulation with phytohaemagglutinin ( PHA ), only low levels of IL-1 beta, IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals
Ichiyama et al., Inflamm Res 2004 : Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation, interleukin-6 (IL-6) production, and E-selectin expression induced by TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively
Muñoz-Fernández et al., Immunology 1992 : Furthermore, TNF was able to increase IL-2R alpha mRNA levels on SP thymocytes
Enomoto et al., Biochem Biophys Res Commun 2004 (Body Weight...) : ERBA did not affect IL-2- , IL-3-, and GCSF dependent cell growth, or tumor necrosis factor alpha induced growth suppression, nor did ERBA affect osteoclast formation induced by IL-11, leukemia inhibitory factor, and 1alpha,25-dihydroxyvitamin D ( 3 )
Cheon et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : When RA FLS are stimulated with interleukin 1 or tumor necrosis factor-a , WISP3 mRNA is significantly increased
Desmet et al., Biochem Pharmacol 2005 : On the contrary, both RSG and TRO significantly potentiated TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells
Kita et al., Nat Immun 1992 : CK-M stimulated thioglycollate induced peritoneal macrophages to produce interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) at concentrations of 1-100 ng/ml, and it also induced IL-2 and interferon-gamma (IFN-gamma) as well as IL-6 production by splenocytes
Kohm et al., Cell Immunol 2005 : CD28 regulates glucocorticoid induced TNF receptor family related gene expression on CD4+ T cells via IL-2 dependent mechanisms
Boehmer et al., Mech Ageing Dev 2005 (Inflammation...) : In contrast, IL-2 stimulated TNF-alpha and IL-6 production was not affected by age
Altomonte et al., Clin Rheumatol 1992 (Arthritis, Rheumatoid) : Further IL-1b and TNF-a were significantly elevated in RA patients with active disease and IL-2 was significantly reduced when compared with patients with low active disease
Hsu et al., Int Immunol 1992 : Both IL-4 and IL-10 [ cytokine synthesis inhibitory factor ( CSIF ) ] inhibit IL-2 induced synthesis of IFN-gamma and tumor necrosis factor (TNF)-alpha by human PBMC
Xu et al., Vaccine 2006 (Diarrhea) : Specific IgG prevents enteroinvasive Escherichia coli/Salmonella typhi induced diarrhea and may exert an effective protection by enhancing splenic NK cell activity, elevating IL-2 level and inhibiting excessive release of TNF-alpha in mice
Edwards et al., Surgery 1992 : Because IL-2 has limited direct effects on neutrophils and acutely induces the production of tumor necrosis factor-alpha (TNF) , we hypothesized that the acute microvascular alterations and hemodynamic instability induced by IL-2 were mediated by TNF
Bălăşoiu et al., Rom J Morphol Embryol 2005 (Adenocarcinoma...) : In III and IV stages of prostate cancer the levels of IL-2 were very low and the levels of IL-6 and TNF-alpha were very increased
Beyaert et al., Cytokine 1991 : This study shows the in vitro effect of LiCl on the TNF induced or interleukin 1 (IL-1) induced expression of IL-6, granulocyte-macrophage colony stimulating factor ( GM-CSF ), IL-3, IL-2 , and the IL-2 receptor-alpha ( IL-2R alpha )
Ware et al., J Immunol 1991 : These results, combined with the known ability of TNF to induce IL-2R expression, indicate that TNF and IL-2 form a reciprocating receptor amplification circuit
Wei et al., Biochimie 2006 : Promutoxin is also able to stimulate the release of IL-12, TNFalpha , IL-6 and IL-1beta from human monocytes, and induce IL-2 , TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Kasid et al., Cancer Res 1990 : In conjunction with IL-2, cytokines such as IFN-alpha, IFN-gamma, or TNF did not interfere with IL-2 induction of TNF and LT mRNA ... In particular, they reveal the previously unrecognized function of IL-4 in antagonizing the IL-2 induction of TNF , LT, and Tac mRNA in PBMC
Weil et al., Mol Cell Biol 1990 : RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2 ... We have previously reported that tumor necrosis factor beta (TNF beta) expression is induced by interleukin-2 (IL-2) in the murine lymphocytic T-cell line CTLL-2
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Elbaz et al., J Clin Invest 1991 (Acute Disease...) : The TNF effect does not occur at 0 degrees C and can not be induced by IL-2 , IL-6, or GM-CSF
Naume et al., J Immunol 1991 : Low levels of TNF were produced in response to IL-7 at day 5, as opposed to a 50-fold higher TNF production in response to IL-2
Naranjo-Gómez et al., Eur J Immunol 2007 : This reduction was dose and time dependent, suggesting a regulatory role of IL-2 in TNF secretion that might occur at the post-transcriptional level
Tzung et al., Cancer Immunol Immunother 1991 : Endogenous interferon alpha/beta produced by Kupffer cells inhibits interleukin-1, tumor necrosis factor alpha production and interleukin-2 induced activation of nonparenchymal liver cells
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R, IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha , IL-2, and IL-10 secretion
Liu et al., J Autoimmun 2007 (Colitis...) : Anti-TNF significantly suppressed leukocyte infiltration in the inflamed colon, and down-regulated IFN-gamma, IL-2 and TNF secretion by lamina propria CD4 ( + ) T cells
Choi et al., FEMS Immunol Med Microbiol 2007 (Candidiasis) : CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving tumor necrosis factor-alpha dependent interleukin-12 induction
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Nishioka et al., Bone Marrow Transplant 2008 : In addition, fludarabine inhibited TNF-alpha stimulated production of IL-2 and IFN-gamma, which play important roles in the onset of GVHD, in Jurkat cells
Kaminuma et al., J Immunol 2008 : Ectopic expression of NFATc2 but not NFATc1, especially its short isoform, enhanced TNF-alpha synthesis in human T cells at the gene transcription level, whereas both NFATs augmented IL-2 expression
Meulders et al., Presse Med 1991 : IL-2 increased TNF-alpha production and was more effective under normal conditions ( 10 to 15 fold increase ) than during rejection episodes ( 1.3 to 2.4 fold )
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Moxey-Mims et al., J Immunol 1991 : This inhibitory effect of IL-2 on TNF was reversed by anti-IL-2 antibody and mAb directed against the low affinity IL-2R ( anti-Tac ), whereas mAb directed against the intermediate affinity receptor ( mik-beta 1 ) had no such effect
Bello-Fernandez et al., Immunology 1991 (Neoplasms) : IL-4 acts as a homeostatic regulator of IL-2 induced TNF and IFN-gamma ... IL-2 induced high levels of TNF and IFN-gamma secretion in both groups ... TNF levels induced by IL-2 were similarly reduced by IL-4 both in normal donors ( P less than 0.003 ) and in patients ( P less than 0.01 )
Campos Alberto et al., Immunology 2009 : TNF-alpha but not IL-12 increases the expression of IL-2Rbeta on CB Vgamma9 T cells
Danis et al., Clin Exp Immunol 1991 : Effects of granulocyte-macrophage colony stimulating factor ( GM-CSF ), IL-2 , interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes ... The effects of GM-CSF, IL-2 , IFN-gamma, TNF-alpha and IL-6 on the production of IL-1 ( both secreted and cell associated ) and TNF-alpha by peripheral blood monocytes were studied ... GM-CSF did not enhance TNF-alpha secretion induced by IL-2 or TNF-alpha ... In contrast, IL-2 synergistically enhanced TNF-alpha secretion induced by IFN-gamma
Karttunen et al., J Clin Microbiol 1991 (Tularemia) : Francisella tularensis induced in vitro gamma interferon, tumor necrosis factor alpha, and interleukin 2 responses appear within 2 weeks of tularemia vaccination in human beings
Remick et al., Immunol Invest 1991 : Interleukin 2 induces tumor necrosis factor gene expression in vivo ... We therefore examined the hypothesis that IL-2 induces TNF gene expression in vivo
Hall et al., Res Commun Chem Pathol Pharmacol 1991 (Kidney Diseases) : Many of the side effects of IL-2 immunotherapy are due to IL-2 induced synthesis of tumour necrosis factor-alpha (TNF-a) and can be alleviated by co-administration of steroids
Du et al., Chin J Integr Med 2009 (Carcinoma, Non-Small-Cell Lung...) : The level of CD3 ( + ), CD4 ( + ), the ratio of CD4 and CD8 ( + ), IgA, IgM, IgG and IL-2 decreased in patients with NSCLC on day 1 after operation, and the level of CD8 and TNF-alpha increased compared to pre-operation
Chen et al., J Surg Res 2010 : The IL-2-shRNA attenuated acute rejection with decreased apoptosis of hepatocytes and reduced cytokine production of IL-2, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in the graft
Barak et al., Immunol Lett 1991 : Gamma interferon ( gamma-IFN ), lipopolysaccharide (LPS)-gamma or interleukin-2 (IL-2) induced tumor necrosis factor alpha (TNF alpha) production by both macrophages and peripheral blood mononuclear cells ( PBMC ), was increased in the presence of neopterin
Fischer et al., J Immunol 1990 : IL-2 and IL-4 were both growth promoting for human T cells but only IL-2 could efficiently induce TNF production
Campbell et al., Clinical and vaccine immunology : CVI 2009 : Candida stimulated PBMC preferentially induced IFN-gamma and TNF-alpha production, with reduced production of IL-2 and IL-10
Gruenbacher et al., Blood 2009 : Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and interleukin-2 (IL-2) resulted in the rapid expansion of gammadelta T cells as well as in IFN-gamma, TNF-alpha , and IL-1beta but not in IL-4, IL-10, or IL-17 production
Schiller et al., Cancer Res 1991 (Neoplasms) : TNF significantly ( P less than 0.05 for all ) enhanced serum beta 2-microglobulin, serum neopterin, and serum interleukin-2 receptor ( Tac antigen ) levels
Novogrodsky et al., Cell Immunol 1991 : FAC stimulates the production of TNF-alpha and IFN-gamma in human PBM, and this effect is potentiated by IL-2
Chakraborty et al., Clin Immunol Immunopathol 1991 : The suppression of high-affinity IL-2R induction on T cells did not result from tumor necrosis factor-alpha and beta or from transforming growth factor-beta as these cytokines were not detected in the cell-free supernatant from the MJ TIL culture
Negishi et al., Am J Reprod Immunol 2011 : ( ii ) TNF-a was also induced by LPS but was not affected by the presence of IL-2 and IL-12
Tyagi et al., Mol Cell Endocrinol 2010 : In addition, like 17beta-estradiol, presence of medicarpin inhibited TNFalpha induced upregulation of interleukin-1 , and -6 mRNA levels in osteoblasts
Gutteberg et al., APMIS 1991 (Sepsis) : Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF), interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
DeBenedette et al., J Immunother 2011 : By using multiparameter flow cytometry, the quantities of IL-12 needed to prime naive antigen-reactive T cells to simultaneously produce interferon-? and tumor necrosis factor-a in the presence or absence of IL-2 secretion in conjunction with lytic activity defined by CD107a expression can be used to determine the overall potency of a DC product
Bergmann et al., Nat Immun Cell Growth Regul 1990 (Melanoma) : Therefore, we investigated the effect of interferon-alpha ( IFN-alpha ), IFN-gamma and tumor necrosis factor ( TNF-alpha ) on the induction of LAK activity by IL-2 , and the induction of IFN-gamma and TNF-alpha by IL-2
Pawelec et al., Mol Biother 1990 (Neoplasms) : Plasma tumor necrosis factor-alpha (TNF-alpha) levels, but not interferon-gamma (IFN-gamma) levels, increased during IL-2 treatment, but spontaneous and IL-2 stimulated TNF-alpha secretion in vitro remained abnormally low
Numerof et al., Cell Immunol 1990 : We examined cytokine production by IL-2 treated, nonmonocytic PBMC and found that a population of nonadherent low-density cells ( NLDC ) produced both IL-1 beta and TNF alpha in response to IL-2
Fischer et al., J Immunol 1990 : The lymphokines IL-2 and IL-4 promoted the growth of human PHA triggered T cells, but only IL-2 induced the production of IFN-gamma and TNF ... IL-6 did not influence IFN-gamma or TNF production or T cell proliferation induced by PHA-IL-2 and did not modulate IL-1 induced IFN-gamma production ... We demonstrate, at the clonal level, that the optimal production of IFN-gamma by human Th cells requires both IL-1 and IL-2, whereas the production of TNF and T cell proliferation are induced by IL-2 alone
Chan et al., Int J Oncol 1997 : Involvement of interleukin-1 in the differentiation inducing activity of tumor necrosis factor-alpha on a murine myeloid leukemia ( WEHI-3B JCS )
Yang et al., Cancer Res 1990 (Lung Neoplasms) : Studies of cytokine receptor expression indicated that OKT3 plus IL-2 plus TNF caused an earlier up-regulation of the IL-2 receptor beta chain ( Tac ) and higher TNF receptor expression by day 6 compared to 100 units/ml IL-2 alone
Carlo et al., J Pediatr 2011 (Cerebral Palsy...) : The analyses were focused on 5 cytokines ( interleukin [ IL] 1ß ; IL-8 ; tumor necrosis factor-a ; regulated upon activation, normal T-cell expressed, and secreted ( RANTES ) ; and IL-2 ) reported to be most predictive of CP in term and late preterm infants
Takeda et al., Int Immunopharmacol 2011 (Orthomyxoviridae Infections) : On day 2, tumor necrosis factor (TNF)-a production in BALF was also reduced significantly, but interferon-a, interleukin-12 , and interferon-? productions were augmented and natural killer ( NK ) cell activity was significantly elevated
Plaetinck et al., J Immunol 1990 : IL-1, but not TNF , also stimulates transient secretion of IL-2
Mier et al., Blood 1990 : Inhibition of interleukin-2 induced tumor necrosis factor release by dexamethasone : prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2 associated side effects ... To determine if dexamethasone can exert a similar suppressive effect on IL-2 induced TNF synthesis in vivo, the concentration of TNF alpha was measured in plasma samples serially obtained ( a ) from cancer patients participating in a phase I dose escalation clinical trial with high-dose IL-2 administered in conjunction with dexamethasone ( IL-2/Dex ) and ( b ) from patients participating in concurrent studies with IL-2 alone ... They further suggest that the altered spectrum and reduced severity of IL-2 side effects observed in patients receiving dexamethasone may be attributable in part to the suppressive effect of steroids on IL-2 induced TNF synthesis
Ma et al., J Pharmacol Sci 2012 : We also demonstrated that pretreatment of cells with this compound prevented TNF-a induced expression of NF-?B target genes, such as interleukin 6, interleukin 8, monocyte chemotactic protein 1, cyclooxygenase-2 and inducible nitric oxide
Matsebatlela et al., Biol Trace Elem Res 2012 : Using ELISA assays, lithium was demonstrated to induce production of pro-inflammatory cytokines, IL-6 and TNF-a , while inhibiting release of anti-inflammation related IL-2 and IL-10 in a dose dependent fashion
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Gunaydın et al., J Pediatr Surg 2012 (Acute Lung Injury...) : Aspiration of gastrointestinal decontamination agents produced histopathologic changes, elevated levels of malondialdehyde and surfactant protein D, reduced levels of antioxidant enzymes, and increased expression of inflammatory cytokines interleukin-1ß and tumor necrosis factor a. Curcumin treatments effectively attenuated the rats ' pulmonary inflammation responses ( as shown by reduced alveolar damage ), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor a and interleukin-1ß
Chouaib et al., Pathol Biol (Paris) 1990 : The IL-2/TNF driven generation of LAK activity involves the induction of high affinity IL-2 receptors on LGL and occurs without promoting a significant proliferation, suggesting a functional activation rather than a proliferative expansion of LAK precursors
McBride et al., Cancer Res 1990 : In vitro pretreatment of macrophages with IL-4 largely abolished their ability to synthesize TNF in response to IL-2 or lipopolysaccharide ... Overall, these results demonstrate that IL-2 and IL-4 can act antagonistically to regulate TNF production by macrophages
Elias et al., Am J Respir Cell Mol Biol 1990 : We determined whether normal human lung fibroblasts expressed cell associated thymocyte stimulating activity in response to recombinant interleukin-1 ( rIL-1 ) ( alpha and beta ) and recombinant tumor necrosis factor ( rTNF )
Tsukamoto et al., Inflamm Bowel Dis 2013 : : Enzyme linked immunosorbent assay and AP assay showed interleukin-1ß induced TNF-a shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells
Gowen et al., Endocrinology 1990 : Human osteoblast cultures derived as out-growths from trabecular bone released tumor necrosis factor ( TNF alpha ) upon stimulation of the cells with human recombinant interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ), human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ), and bacterial lipopolysaccharide ( 5-500 ng/ml )
Liu et al., J Immunol 1990 : Although perforin ( hemolytic ) activity was detected in unstimulated R8i, it was induced 2- to 14-fold in the presence of IL-2 , IL-3, IL-4, and IL-6, and to a lesser degree ( less than 4-fold ) by TNF and IFN-gamma
Satoh et al., Jpn J Cancer Res 1986 : Priming effect of interferons and interleukin 2 on endogenous production of tumor necrosis factor in mice ... The effects of interferons ( IFNs ) and interleukin 2 (IL 2) on endogenous production of tumor necrosis factor (TNF) were investigated in mice
Lee et al., J Immunol 1987 : Induction of interleukin 2 receptor ( TAC ) by tumor necrosis factor in YT cells ... The effect of human recombinant tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) on interleukin 2 receptor (IL-2R) expression on YT cells was examined ... TNF-alpha , like IL-1 beta, induced increased levels of IL-2R expression on YT cells with similar kinetics of induction
Satoh et al., J Biol Response Mod 1987 (Neoplasms) : The priming effect of endogenous biological response modifiers ( BRMs ), interferons ( IFNs ), and interleukin-2 (IL2) , and the triggering effect of BRMs of bacterial origin, OK-432 and Corynebacterium parvum, on endogenous production of the tumor necrosis factor (TNF) were investigated in mice
Hampson et al., Am J Physiol 1989 : The studies demonstrate that interleukin 1 (IL-1), tumor necrosis factor (TNF), gamma-interferon ( IFN ), and interleukin 2 (IL-2) increase the adherence of T-lymphocytes to fibroblasts in a dose- and time dependent manner
Heslop et al., Blood 1989 (Leukemia, Myeloid, Acute...) : In vivo induction of gamma interferon and tumor necrosis factor by interleukin-2 infusion following intensive chemotherapy or autologous marrow transplantation
Lin et al., Immunopharmacology 1989 : Of the TG-15-I and TG-15-II, the former stimulates higher IL-2 production whereas the latter enhances IFN-gamma and TNF production
Pawelec et al., J Immunol 1989 : In contrast, TNF-alpha did block proliferative responses to IL-2 , but only by those clones which were incapable of responding to IL-4
Owen-Schaub et al., J Immunol 1989 : Regulation of lymphocyte tumor necrosis factor receptors by IL-2 ... Our findings demonstrate that IL-2 , alone and in serum-free conditions, can trigger and regulate TNF receptor expression on normal lymphocytes
Kasid et al., J Immunol 1989 : The results of these in vivo studies suggest that IL-2 may be a physiologic inducer of TNF and IL-6 which, because of their pleiotropic effects, may be important endogenous signals in the body 's immune response and account for some of the physiologic changes seen in patients receiving high dose IL-2
Lowenthal et al., J Immunol 1989 : TNF-alpha induces the expression of IL-2R and promotes the proliferation and differentiation of T and B cells ... These findings suggest that TNF-alpha stimulated expression of the IL-2R alpha gene involves the induction of specific DNA binding proteins that in turn interact with a kappa B-like promoter element and facilitate activation of this transcription unit
Chouaib et al., Proc Natl Acad Sci U S A 1988 : Specific binding of 125I labeled TNF to LGL was increased by IL-2 stimulation
Turner et al., Eur J Immunol 1987 (Autoimmune Diseases) : Additionally we found that IL2 alone was sufficient to induce TNF in these cells when they had been precultured with phytohemagglutinin for 7 days to express IL 2 receptors
Plaetinck et al., Eur J Immunol 1987 : Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat x mouse T cell hybrid ... Here we show that highly purified recombinant TNF , in combination with interleukin 2 (IL2), can induce IL2 receptor expression and cytolytic activity in a rat x mouse T cell hybrid ( PC60 )
Blay et al., C R Acad Sci III 1988 : We also demonstrate that IL-2 induced an increase of specific TNF binding to LGL
Weil et al., Oncogene Res 1988 : Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell lines ... This led us to investigate the regulation by IL2 of TNF-alpha , TNF-beta, and interferon-gamma (IFN-gamma) mRNA
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Bachwich et al., Biochem Biophys Res Commun 1986 : Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages ... We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages ... Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M
Hoffman et al., Lymphokine Res 1986 : The effects of tumor necrosis factor on the production of interleukin-1 by macrophages
Le et al., J Immunol 1987 : Induction of membrane associated interleukin 1 by tumor necrosis factor in human fibroblasts
Männel et al., Rev Infect Dis 1987 : No TNF induced production of interleukin 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures
Libby et al., Am J Pathol 1986 : Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells
Ferreira et al., Drugs 1993 (Hyperalgesia...) : The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively
Hamilton et al., J Clin Invest 1995 : TNF alpha and IP-10 mRNA expression induced by IFN gamma and IL-2 was markedly more sensitive to suppression by oxidized LDL than that induced by LPS
Kita et al., C R Seances Soc Biol Fil 1994 : Although the expressions of IL-1 beta, IL-4, IL-5, IL-6, TNF-alpha and IFN-gamma mRNA were detected in all the embryos tested, the expressions of IL-2 , IL-3, IFN-alpha and IFN-beta mRNA were not detected at all
Benveniste et al., Int J Dev Neurosci 1995 : In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Sperber et al., Clin Diagn Lab Immunol 1995 : In LPL, there was no SEE induced IL-2 or IL-4 production, but IL-6, TNF , and gamma interferon were induced ... In IEL, SEE induced no IL-2 , IL-4, or gamma interferon but produced IL-6 and TNF, while SEB stimulation resulted in no IL-2 or gamma interferon but did result in detectable IL-4, IL-6, and TNF
Cesano et al., Cancer Immunol Immunother 1995 : CsA did not impair the ability of TALL-104 and LAK cells to produce interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, and granulocyte/macrophage-colony-stimulatory factor ( GM-CSF ) in response to IL-2 , IL-12, or tumor targets
Meffert et al., Anticancer Res 1995 (Carcinoma, Renal Cell...) : The effect of low-dose human recombinant interleukin-2 ( rIL-2 ) on the induction of secondary tumor necrosis factor-alpha (TNF-alpha) in vivo was studied in 16 patients with metastatic renal cell carcinoma
Aggarwal et al., Exp Cell Res 1995 : Diminished responsiveness of senescent normal human fibroblasts to TNF dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B
Jewett et al., J Clin Immunol 1995 : This was corroborated in experiments demonstrating that when Free cells were cultured with both IFN-alpha and IL-2, a significant inhibition was observed for both the IL-2 dependent secretion of TNF-alpha and proliferation
Schwarz et al., J Immunother Emphasis Tumor Immunol 1994 : IL-2 induced release of TNF-alpha was dramatically reduced by IL-10 ; however, the expression of lymphokine activated killer ( LAK ) activity was not affected
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Trentin et al., Br J Cancer 1995 (Carcinoma...) : To this end, TIL lines and freshly isolated TILs were evaluated for ( a ) the expression and the functional role of TNF receptors following culture in the presence of interleukin 2 (IL-2) and ( b ) the production of TNF-alpha following culture with IL-2 and the role of this cytokine in IL-2-driven TIL proliferation
Rhoades et al., Cell Immunol 1995 : Regulation of TNF-alpha promoter activity by IL-2 , IFN-gamma, GM-CSF, and IL-4 was examined in the U937 macrophage cell line and the MLA 144 T cell line
Carreer et al., AIDS Res Hum Retroviruses 1994 : Secretion of IL-2 and TNF-alpha, surface expression of IL-2R, and DNA binding activity of NF-kappa B and AP-1 ( Fos/Jun ) complex in response to phorbol myristate acetate, TNF-alpha , or immobilized antibodies to CD3 were monitored
Pimentel-Muiños et al., J Biol Chem 1994 : The addition of either TNF alpha or IL-2 partially recovered cyclosporin A-induced IL-2R alpha inhibition, but only TNF alpha completely recovered NF.kappa B activation
Seatter et al., Arch Surg 1994 (Disease Models, Animal) : Tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment
Hladik et al., J Immunol 1994 : A single application of 30,000 U nIL-2 induced selective and long lasting expression of IL-2 , IFN-gamma, and GM-CSF genes, which was not accompanied by accumulation of TNF-alpha and IL-6 mRNAs
Armant et al., J Exp Med 1994 : Finally, TNF-alpha production in response to IL-2 and sCD23 precedes IFN-gamma and IFN-gamma secretion is significantly inhibited by anti-TNF-alpha mAb, indicating that the sCD23 costimulatory signal for IFN-gamma production may be partially mediated by TNF-alpha release
Baxevanis et al., Immunopharmacol Immunotoxicol 1994 : The requirement for IL-1 beta and TNF-alpha in both IL-2 production and generation of suppressor activity was shown by three different approaches which included ( a ) blocking of HLA-DR molecules on monocytes which prevented monokine consumption during the early stages of culture, ( b ) blocking of HLA-A, B,C molecules on monocytes which prevented monokine consumption and IL-2 production late in culture, and ( c ) neutralization of monokine activity late in culture which resulted in highly reduced IL-2 production
Blasi et al., Infect Immun 1994 : Moreover, pretreatment of macrophages with recombinant TNF for 3 h enhances TNF and induces interleukin-1 production in response to both forms of Candida, while pretreatment for 18 h renders macrophages refractory to any stimuli
Jewett et al., J Clin Immunol 1994 : Activation by IL-2 is dependent on endogenous secretion of tumor necrosis factor-alpha (TNF-alpha) by the free cells
Saito et al., Nihon Hinyokika Gakkai Zasshi 1994 (Carcinoma, Transitional Cell...) : Thus, the present study failed to demonstrate the involvement of a direct action of TNF-alpha , activation of immunological cells by IL-2 or its direct action as an anti-tumor effect of intravesical instillation of BCG
Spagnoli et al., Cell Immunol 1993 : Interestingly, rhIL-10 dose-dependently inhibited the production of IFN-gamma and TNF-alpha induced by IL-2 , but had no effects on PBMC proliferation and generation of LAK activity
Pimentel-Muiños et al., J Immunol 1994 : Those results indicate that the autocrine secretion of TNF-alpha and IL-2, and not the primary stimulus itself, contribute mostly to the regulation of IL-2R ; thereby playing a very important role in quantitative control of T cell proliferation and leaving to the specifically TCR/CD3 derived signals the triggering role in T cell activation
Guilhot et al., J Virol 1993 : We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) and interleukin-2 (IL-2) downregulate the hepatic steady-state content of hepatitis B virus ( HBV ) mRNA in vivo in HBV-transgenic mice and that the IL-2 effect is mediated by TNF-alpha
Couez et al., Mol Immunol 1994 : In these transfectants, CD28 mAbs, similarly to CD3 mAbs, were able to induce Ca2+ mobilization, IL-2 promoter induction ( measured as beta-galactosidase activity in T cells hybridomas pre transfected with the IL-2-lac Z reporter gene ), IL-2 secretion, TNF alpha production and apoptosis ( observed as growth arrest and genome fragmentation )
Iho et al., Scand J Immunol 1993 : TNF-alpha mediated regulation of low-dose IL-2 activation occurs even at late stages ( effector phase ) of LAK development
Panzer et al., Clin Exp Immunol 1993 : We show in this system that exogenously added IL-1 beta, IL-6 and TNF-alpha induces IL-2 receptor (R) up-regulation and IL-2 production, and proliferation by both CD4+ and CD8+ cells ... These findings suggest that IL-6 and TNF-alpha will induce IL-2R up-regulation/IL-2 secretion via the induction of IL-1 beta production
Larsson et al., Leukemia 1993 (Leukemia, Lymphocytic, Chronic, B-Cell) : Interleukin-2 enhances the production of tumor necrosis factor-alpha in activated B-type chronic lymphocytic leukemia ( B-CLL ) cells ... A moderate increase in TNF-alpha secretion was also induced by TPA or IL-2 alone ... IL-4 did not have any major effects on the production of TNF-alpha in activated cells, but inhibited the IL-2 induced production of TNF-alpha in SAC activated cells
Jewett et al., Cell Immunol 1993 : Pivotal role of endogenous TNF-alpha in the IL-2-driven activation and proliferation of the functionally immature NK free subset ... However, IL-2 mediated TNF-alpha secretion was not affected by the addition of anti-TNF-alpha antibody
Dao et al., Cell Immunol 1993 : In addition, the IL-2 production by PHA stimulated MOLT-13 and MOLT-14 cells was also augmented by human natural tumor necrosis factor-alpha (TNF-alpha) in a dose dependent manner but was inhibited by IFN-alpha even at low concentrations ( 10 IU/ml )
Wei et al., J Immunol 1993 : Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta ... The induction of TNF-alpha and functional activation of neutrophils by IL-2 is therefore an important immunomodulatory property of IL-2 that has not heretofore been recognized
Heaton et al., Cancer Res 1993 : These data suggest the interaction of IL-2 and the high-affinity IL-2 receptor on human PBMC or peripheral blood lymphocyte is required for maximal secretion of IL-1 beta, TNF-alpha , TNF-beta, and IFN-gamma
Fritz et al., J Surg Res 1996 (Fibrosarcoma...) : We sought to determine if the antitumor effect of combined WBHT+IL-2 is mediated by TNF alpha ... These data demonstrate significantly increased TNF alpha levels in mice treated with combined therapy and abrogation of the antitumor effect of WBHT+IL-2 therapy by the addition of anti-TNF alpha Ab with a tumor growth rate similar to that observed in untreated mice, suggesting that the antitumor effect of WBHT+IL-2 is mediated at least in part by TNF alpha
Gerondakis et al., Proc Natl Acad Sci U S A 1996 : Exogenous IL-2 , which restitutes the proliferative response of the anti-CD3- and anti-CD28 treated Rel-/- T cells, restores production of IL-5, TNF-alpha , and IFN-gamma, but not IL-3 and GM-CSF expression to approximately normal levels
Lentsch et al., J Leukoc Biol 1996 (Pleural Effusion) : Interleukin-10 inhibits interleukin-2 induced tumor necrosis factor production but does not reduce toxicity in C3H/HeN mice ... However, IL-10 did inhibit IL-2 induced increases in serum TNF-alpha , which was accompanied by a decrease in Golgi apparatus and rough endoplasmic reticulum in alveolar macrophages
Becher et al., J Clin Invest 1996 : Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
Jewett et al., J Clin Immunol 1996 : IFN-alpha activated the secretion of IFN-gamma only, whereas IL-2 activated the secretion of both TNF-alpha and IFN-gamma by the binder and killer subsets and secretion was augmented by the addition of K562 to the cultures
Yamamoto et al., Eur J Pharmacol 1996 (Disseminated Intravascular Coagulation) : Plasma interleukin-1 and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) inhibited the increased plasma interleukin-1 ( 100.0 % ) and plasma TNF-alpha ( 89.2 % ) levels
Ortiz-Arduan et al., Am J Physiol 1996 (Endotoxemia) : Lipopolysaccharides (LPS), interleukin-1 beta, interferon-gamma (IFN-gamma), and TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
McInnes et al., Nat Med 1997 (Arthritis, Rheumatoid) : In contrast, IL-2 induced significantly lower TNF-alpha production in either cell-contact dependent or direct culture, and IL-8 and MIP-1 alpha were ineffective
Klegeris et al., Brain Res 1997 (Alzheimer Disease) : First, it was shown that THP-1 cells could be induced to secrete significant amounts of TNF-alpha by interleukin-1 , lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other
Campbell et al., J Infect Dis 1997 (Liver Abscess, Amebic) : Interleukin (IL)-2 , IL-4, and tumor necrosis factor-alpha responses during Entamoeba histolytica liver abscess development in gerbils
Hofmeister et al., J Biol Chem 1997 : In this cell line ( EL4D6/76 ), tumor necrosis factor induced ligand/receptor internalization, NFkappaB nuclear translocation, IL-2 production, and the activation of neutral (N)-SMase and acid ( A ) -SMase
Berghella et al., Cancer Immunol Immunother 1998 (Colorectal Neoplasms) : To address these questions at the immunological level in a group of patients and healthy subjects, we determined the sIL-2R level in the serum and its release from peripheral blood mononuclear cells ( PBMC ) as a function of tumour necrosis factor (TNF) alpha , IL-1 alpha, IL-1 beta, IL-2, interferon (IFN) gamma, IL-4, IL-6 and IL-10 levels in the serum and PBMC production ; and PBMC proliferative responses to IL-2 , IL-4 and anti-CD3 monoclonal antibody ( CD3 ), variously combined
Hulkkonen et al., Br J Haematol 1998 (Leukemia, Lymphocytic, Chronic, B-Cell) : Mitogenic stimulation with phorbol 12-myristate 13-acetate ( PMA ) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage ( Binet A ) disease
Li et al., Eur J Pharmacol 1998 (Multiple Sclerosis) : Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased
McDermott et al., Clin Cancer Res 1998 (Carcinoma, Renal Cell...) : Whole-blood functional assays indicated that sufficient s ( CHO ) IL-1R was present in the circulation at top dose levels to inhibit the in vitro effects of IL-1beta on IL-8 induction ; however, no effect on IL-2 induced IL-8 induction, or on the IL-1beta- or IL-2 induced tumor necrosis factor production, was observed
Bryson et al., Arch Biochem Biophys 1998 : It potently inhibited interleukin 1- and tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage
Macciò et al., Gynecol Oncol 1998 (Ovarian Neoplasms) : The serum levels of interleukin-(IL-)1 alpha, IL-1 beta, IL-2, IL-6, TNF alpha , and sIL-2R and the proliferative response of peripheral blood mononuclear cells ( PBMC ) to phytohemagglutinin ( PHA ), anti-CD3 monoclonal antibody ( mAb ), recombinant IL-2 ( rIL-2 ), and the combination of PHA or anti-CD3 mAb with rIL-2 were studied and correlated with serum levels of C-reactive protein (CRP) in women with advanced epithelial ovarian cancer
Fiedler et al., Am J Respir Cell Mol Biol 1998 : The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells
Aihara et al., Dig Dis Sci 1998 : Live H. pylori induced production of many cytokines, such as IL-1beta, IL-10, IL-8, IFN-gamma, and TNF-alpha , whereas we could not detect IL-2 or IL-4
Plata-Salamán et al., Am J Physiol 1998 (Fever...) : The results show that 1 ) both IL-1beta and IL-6 induce fevers in obese and lean rats ; 2 ) IL-1beta induces a significantly higher fever response in obese rats than it does in lean rats ; 3 ) IL-6 induces a significantly higher fever response in lean rats than it does in obese rats ; 4 ) IL-2 induces a moderate fever response in lean but not obese rats ; 5 ) TNF-alpha induces a similar fever response in obese and lean rats ; and 6 ) the fevers induced by each effective cytokine have different time courses
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Cembrzyńska-Nowak et al., Arch Immunol Ther Exp (Warsz) 1998 (Carcinoma, Small Cell...) : Exogenous interleukin 2 regulates interleukin 6 and nitric oxide but not interferon gamma and tumor necrosis factor alpha production in bronchoalveolar leukocytes from patients with small cell lung cancer
Wei et al., J Surg Res 1999 : We investigated the role of anti-TNF in the regulation of MHC class II antigens and cytokine mRNA expression of TNF, interferon-gamma (IFN), IL-2 , IL-4, and IL-10 in cardiac allografts to elucidate its immunological mechanism