J Leukoc Biol 1996,
PMID: 8699123
Lentsch, A B; Edwards, M J; Sims, D E; Nakagawa, K; Wellhausen, S R; Miller, F N
Immunotherapy with interleukin-2 (IL-2) is limited by severe side effects thought to be mediated by the activation of immune effector cells and the induction of secondary cytokines including tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). In C3H/HeN mice the primary IL-2 toxicity is the production of pleural effusion with subsequent respiratory compromise. IL-10 is a cytokine that has been shown to inhibit the generation of secondary cytokines in vitro and in vivo. In this study, in C3H/HeN mice, we tested the ability of IL-10 to inhibit IL-2-induced mononuclear cell and alveolar macrophage activation and IL-2-induced increases in serum TNF-alpha and IFN-gamma, all of which may contribute to the generation of toxicity. IL-10 was ineffective at reducing IL-2-induced pleural effusion. However, IL-10 did inhibit IL-2-induced increases in serum TNF-alpha, which was accompanied by a decrease in Golgi apparatus and rough endoplasmic reticulum in alveolar macrophages. In addition, IL-10 combined with IL-2 increased mononuclear cell activation, which may limit the ability of IL-10 to inhibit IL-2-induced IFN-gamma production and pulmonary injury.
Diseases/Pathways annotated by Medline MESH: Pleural Effusion
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Text Mining Data
tumor necrosis factor ⊣ Interleukin-10: "
Interleukin-10 inhibits interleukin-2 induced
tumor necrosis factor production but does not reduce toxicity in C3H/HeN mice
"
tumor necrosis factor → interleukin-2: "
Interleukin-10 inhibits interleukin-2 induced tumor necrosis factor production but does not reduce toxicity in C3H/HeN mice
"
TNF-alpha ⊣ IL-10: "
However, IL-10 did inhibit IL-2 induced increases in serum TNF-alpha , which was accompanied by a decrease in Golgi apparatus and rough endoplasmic reticulum in alveolar macrophages
"
TNF-alpha → IL-2: "
However, IL-10 did inhibit IL-2 induced increases in serum TNF-alpha , which was accompanied by a decrease in Golgi apparatus and rough endoplasmic reticulum in alveolar macrophages
"
IFN-gamma ⊣ IL-10: "
In addition, IL-10 combined with IL-2 increased mononuclear cell activation, which may limit the ability of IL-10 to inhibit IL-2 induced IFN-gamma production and pulmonary injury
"
IFN-gamma → IL-2: "
In addition, IL-10 combined with IL-2 increased mononuclear cell activation, which may limit the ability of IL-10 to inhibit IL-2 induced IFN-gamma production and pulmonary injury
"
Manually curated Databases
No curated data.