◀ Back to IFNG
IFNG — IFNGR1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IFNGR1
→
IFNG
(increases)
Igarashi et al., J Biol Chem 1994
Evidence: In this report, we show that binding of IFN-gamma to HeLa cells initiated a series of events that resulted in the extremely rapid (15 s) tyrosine phosphorylation of not only Jak1, Jak2, and p91 but also the IFN-gamma R.
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2 complex (IFNG-IFNGR1-JAK2)
→
TID1 (DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2 complex (IFNG-IFNGR1-JAK2)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
TID1 (DNAJA3)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1/HSP70 complex (IFNGR1-JAK2-DNAJA3-HSPA1A)
→
IFN-gamma (IFNG)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1/HSP70 complex (IFNGR1-JAK2-DNAJA3-HSPA1A)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
IFN-gamma (IFNG)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta chaperones modulate interferon signaling pathway:
HSP70 (HSPA1A)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/JAK2/TID1 complex (IFNG-IFNGR1-JAK2-DNAJA3)
(modification, collaborate)
-
BioCarta ifn gamma signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK2 complex (JAK1-JAK2-IFNGR1)
→
IFN-gamma (IFNG)
(modification, collaborate)
-
BioCarta ifn gamma signaling pathway:
IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK2 complex (JAK1-JAK2-IFNGR1)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK1/JAK2/JAK2 complex (JAK1-JAK2-IFNGR1-IFNG)
(modification, collaborate)
-
BioCarta ifn gamma signaling pathway:
IFN-gamma (IFNG)
→
IFN-gamma/IFN-gamma R-alpha/IFN-gamma R-beta/IFN-gamma R-alpha/IFN-gamma R-beta/JAK1/JAK1/JAK2/JAK2 complex (JAK1-JAK2-IFNGR1-IFNG)
(modification, collaborate)
-
KEGG Osteoclast differentiation:
IFNG
→
IFNGR1/IFNGR2
(protein-protein, activation)
-
KEGG Natural killer cell mediated cytotoxicity:
IFNG
→
IFNGR1/IFNGR2
(protein-protein, activation)
-
KEGG Natural killer cell mediated cytotoxicity:
IFNA1/IFNA10/IFNA13/IFNA14/IFNA16/IFNA17/IFNA2/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA8/IFNB1/IFNG
→
IFNAR1/IFNAR2/IFNGR1/IFNGR2
(protein-protein, activation)
-
KEGG Natural killer cell mediated cytotoxicity:
IFNG
→
IFNAR1/IFNAR2/IFNGR1/IFNGR2
(protein-protein, activation)
-
KEGG Leishmaniasis:
IFNG
→
Complex of IFNGR1-IFNGR2
(protein-protein, binding/association)
-
KEGG Chagas disease (American trypanosomiasis):
IFNG
→
IFNGR1/IFNGR2
(protein-protein, activation)
-
KEGG Chagas disease (American trypanosomiasis):
IFNG
→
IFNGR1/IFNGR2
(protein-protein, activation)
-
KEGG Toxoplasmosis:
IFNG
→
IFNGR1/IFNGR2
(protein-protein, binding/association)
-
KEGG Tuberculosis:
IFNG
→
IFNGR1
(protein-protein, activation)
-
KEGG Measles:
IFNG
→
IFNGR1/IFNGR2
(protein-protein, activation)
-
KEGG Influenza A:
IFNG
→
IFNGR1/IFNGR2
(protein-protein, binding/association)
-
KEGG Cytokine-cytokine receptor interaction:
IFNG
→
Complex of IFNGR1-IFNGR2
(protein-protein, activation)
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
MEKK1 (MAP3K1)
(modification, activates)
Roy et al., Proc Natl Acad Sci U S A 2002
Evidence: mutant phenotype
-
NCI Pathway Database SHP2 signaling:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gamma (dimer) complex (IFNG)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2)
→
IFN-gamma (dimer) complex (IFNG)
(modification, collaborate)
You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TCPTP complex (IFNGR1-JAK1-JAK2-IFNG-PTPN2)
(modification, collaborate)
Simoncic et al., Curr Biol 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
TCPTP p45 (PTPN2)
(modification, collaborate)
Simoncic et al., Curr Biol 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TCPTP complex (IFNGR1-JAK1-JAK2-IFNG-PTPN2)
→
TCPTP p45 (PTPN2)
(modification, collaborate)
Simoncic et al., Curr Biol 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
CBL (CBL)
(modification, activates)
Alsayed et al., J Immunol 2000
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
CaM/Ca2+/CAMKII complex (CALM2-CAMK2A_CAMK2B_CAMK2D_CAMK2G)
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
Ca2+/CaM complex (CALM2)
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
CaMKII family (CAMK2A/CAMK2B/CAMK2D/CAMK2G)
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
None
(modification, activates)
Nair et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SHP2 (PTPN11)
(translocation, activates)
Wu et al., J Biol Chem 2002
Evidence: assay
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
STAT1 (STAT1)
(modification, activates)
Shuai et al., Science 1992*, Igarashi et al., J Biol Chem 1994, Shuai et al., Science 1993, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Nguyen et al., J Biol Chem 2001, Deb et al., J Immunol 2003
Evidence: mutant phenotype
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
SOCS1 (SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
SOCS1 (SOCS1)
→
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 complex (IFNGR1-JAK1-JAK2-IFNG-SOCS1)
(modification, collaborate)
Alexander et al., Cell 1999, Marine et al., Cell 1999, Ungureanu et al., Mol Cell Biol 2002
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IFN-gamma pathway:
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG)
→
MAP3K11 (MAP3K11)
(modification, activates)
Roy et al., J Biol Chem 2005
Evidence: mutant phenotype
-
Reactome Reaction:
IFNGR1
→
IFNG
(indirect_complex)
Thiel et al., Structure 2000*, Krause et al., Mol Cell Proteomics 2002, Fountoulakis et al., Eur J Biochem 1992*, Argetsinger et al., Mol Cell Biol 2004, Matsuda et al., Biochem Biophys Res Commun 2004, Costa-Pereira et al., J Immunol 2005, Krause et al., Cell Res 2006*, Argetsinger et al., Mol Endocrinol 2010, Igarashi et al., J Biol Chem 1994, Sakatsume et al., J Biol Chem 1995*, Walter et al., Nature 1995*, Kotenko et al., J Biol Chem 1995*, Kaplan et al., J Biol Chem 1996*, Briscoe et al., EMBO J 1996, Feng et al., Mol Cell Biol 1997
-
Reactome Reaction:
IFNGR1
→
IFNG
(reaction)
Thiel et al., Structure 2000*, Aaronson et al., Science 2002, Krause et al., Mol Cell Proteomics 2002, Fountoulakis et al., Eur J Biochem 1992*, Argetsinger et al., Mol Cell Biol 2004, Matsuda et al., Biochem Biophys Res Commun 2004, Costa-Pereira et al., J Immunol 2005, Krause et al., Cell Res 2006*, Argetsinger et al., Mol Endocrinol 2010, Igarashi et al., J Biol Chem 1994, Sakatsume et al., J Biol Chem 1995*, Walter et al., Nature 1995*, Quelle et al., J Biol Chem 1995, Kotenko et al., J Biol Chem 1995*, Shuai et al., Science 1993, Kaplan et al., J Biol Chem 1996*, Briscoe et al., EMBO J 1996, Feng et al., Mol Cell Biol 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
IFNGR1
—
IFNG
Thiel et al., Structure 2000*
-
IRef Bind Interaction:
IFNG
—
IFNGR1
Randal et al., Structure 2001*, Randal et al., Protein Sci 1998*
-
IRef Bind_translation Interaction:
IFNGR1
—
IFNG
(x-ray crystallography)
Thiel et al., Structure 2000*
-
IRef Bind_translation Interaction:
IFNGR1
—
IFNG
(x-ray crystallography)
Randal et al., Protein Sci 1998*
-
IRef Biogrid Interaction:
IFNG
—
IFNGR1
(association, x-ray crystallography)
Thiel et al., Structure 2000*
-
IRef Biogrid Interaction:
IFNG
—
IFNGR1
(direct interaction, pull down)
Kotenko et al., J Biol Chem 1995*
-
IRef Dip Interaction:
IFNG
—
IFNGR1
(direct interaction, x-ray crystallography)
Landar et al., J Mol Biol 2000*
-
IRef Dip Interaction:
IFNG
—
IFNGR1
(direct interaction, x-ray crystallography)
Walter et al., Nature 1995*
-
IRef Hprd Interaction:
IFNG
—
IFNGR1
(in vitro)
Thiel et al., Structure 2000*, Randal et al., Structure 2001*, Subramaniam et al., J Immunol 2002*
-
IRef Hprd Interaction:
IFNG
—
IFNGR1
(in vivo)
Thiel et al., Structure 2000*, Randal et al., Structure 2001*, Subramaniam et al., J Immunol 2002*
-
IRef Innatedb Interaction:
IFNG
—
IFNGR1
(unknown, -)
Thiel et al., Structure 2000*
-
IRef Innatedb Interaction:
IFNG
—
IFNGR1
(unknown, -)
Kotenko et al., J Biol Chem 1995*
-
IRef Intact Interaction:
IFNG
—
IFNGR1
(direct interaction, x-ray crystallography)
Randal et al., Structure 2001*
-
IRef Ophid Interaction:
IFNG
—
IFNGR1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Qing et al., J Biol Chem 2005
:
Mutation of Tyr ( 441 ) also blocked the ability of SOCS-1 to bind to
IFNGR1 and JAK2 in
response to
IFNgamma and the normal down-regulation of STAT1 activation and antiviral activity
Sun et al., Nat Immunol 2006
:
IFN-gamma stimulation
triggered a physical association between the
IFN-gammaR1 and MyD88
Wood et al., Trends Immunol 2006
:
This early production of
IFNgamma by induced Treg cells during an immune response can directly
inhibit the activation and proliferation of
IFNgammaR1- and IFNgammaR2 bearing T cells
Takaki et al., Genes Cells 2006
:
Thus, multiple mechanisms are present for the TGF-beta1 mediated reduction of iNOS production, and we propose a novel mechanism for regulating inflammatory cytokine by an anti-inflammatory cytokine, TGF-beta1 ; i.e. suppression of
IFN-gamma induced STAT1
activation by an association of the
IFNGR1 with the TGF-betaRI
Sun et al., J Interferon Cytokine Res 2007
:
Expression of IRF-1 was induced and expression of active caspase-3 was promoted by IFN-gamma treatment, but
IFN-gamma did not
affect the expression of
IFNGR and p53
Bustamante et al., Curr Opin Immunol 2008
(Genetic Diseases, Inborn...) :
Mutations in
IFNGR1 and IFNGR2 impair
IFN-gamma responses and confer a predisposition to mycobacterial diseases
Wang et al., Cancer Res 2008
(Esophageal Neoplasms) :
Taken together, our results disclosed a new IRF-2 mediated inhibitory mechanism for IFN-gamma induced pathway in esophageal cancer cells :
IFN-gamma induced IRF-2 up-regulation, then up-regulated IRF-2 decreased endogenous IFNGR1 level, and finally, the loss of
IFNGR1 turned to enhance the resistance of esophageal cancer cells to IFN-gamma
Ahmad et al., Osteoarthritis Cartilage 2009
(Osteoarthritis) :
Therefore,
IFN-gammaR1 modulation and weakened endogenous
IFN-gamma response may be important mechanisms in OA pathogenesis and cartilage degradation