Gene interactions and pathways from curated databases and text-mining
Nature 1993, PMID: 8232552

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

Müller, M; Briscoe, J; Laxton, C; Guschin, D; Ziemiecki, A; Silvennoinen, O; Harpur, A G; Barbieri, G; Witthuhn, B A; Schindler, C

We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.

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Text Mining Data

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Manually curated Databases

  • NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → IFN-gamma (dimer) complex (IFNG) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IFN-gamma pathway: IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2) → IFN-gamma (dimer) complex (IFNG) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IFN-gamma pathway: IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2) → SHP2 (PTPN11) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IFN-gamma pathway: IFN-gamma (dimer) complex (IFNG) → SHP2 (PTPN11) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → STAT1 (STAT1) (modification, activates)
    Evidence: mutant phenotype, assay, physical interaction
  • Reactome Reaction: JAK1 → STAT1 (reaction)
  • Reactome Reaction: IFNA2 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA1 → IFNA5 (reaction)
  • Reactome Reaction: IFNA2 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA16 → IFNA17 (reaction)
  • Reactome Reaction: IFNA4 → IFNA7 (reaction)
  • Reactome Reaction: IFNA7 → IFNB1 (reaction)
  • Reactome Reaction: IFNA16 → STAT1 (reaction)
  • Reactome Reaction: IFNA21 → IFNB1 (reaction)
  • Reactome Reaction: IFNA21 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA6 → IFNB1 (reaction)
  • Reactome Reaction: IFNA1 → IFNA4 (reaction)
  • Reactome Reaction: IFNA1 → IFNA17 (reaction)
  • Reactome Reaction: IFNB1 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA7 → STAT1 (reaction)
  • Reactome Reaction: IFNA10 → IFNA16 (reaction)
  • Reactome Reaction: IFNA4 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNB1 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA14 → TYK2 (reaction)
  • Reactome Reaction: IFNA2 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA4 → IFNB1 (reaction)
  • Reactome Reaction: IFNA1 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA21 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA16 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA7 → STAT2 (reaction)
  • Reactome Reaction: IFNA5 → STAT2 (reaction)
  • Reactome Reaction: IFNB1 → JAK1 (reaction)
  • Reactome Reaction: IFNA2 → STAT1 (reaction)
  • Reactome Reaction: IFNA5 → STAT1 (reaction)
  • Reactome Reaction: IFNA14 → IFNA17 (reaction)
  • Reactome Reaction: IFNAR1 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA1 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA2 → IFNA4 (reaction)
  • Reactome Reaction: IFNA17 → STAT1 (reaction)
  • Reactome Reaction: IFNA2 → IFNA5 (reaction)
  • Reactome Reaction: IFNA6 → STAT1 (reaction)
  • Reactome Reaction: IFNA2 → IFNA7 (reaction)
  • Reactome Reaction: IFNA5 → IFNA7 (reaction)
  • Reactome Reaction: IFNA5 → IFNA16 (reaction)
  • Reactome Reaction: IFNA6 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA16 → IFNB1 (reaction)
  • Reactome Reaction: IFNA7 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA2 → IFNA21 (reaction)
  • Reactome Reaction: IFNA7 → IFNA21 (reaction)
  • Reactome Reaction: IFNA2 → IFNAR1 (reaction)
  • Reactome Reaction: STAT2 → STAT2 (reaction)
  • Reactome Reaction: IFNA17 → TYK2 (reaction)
  • Reactome Reaction: STAT2 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA17 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA2 → TYK2 (reaction)
  • Reactome Reaction: IFNA17 → JAK1 (reaction)
  • Reactome Reaction: IFNA10 → IFNA21 (reaction)
  • Reactome Reaction: IFNA10 → STAT2 (reaction)
  • Reactome Reaction: IFNA5 → IFNA17 (reaction)
  • Reactome Reaction: IFNA1 → IFNA10 (reaction)
  • Reactome Reaction: IFNA5 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNB1 → IFNB1 (reaction)
  • Reactome Reaction: STAT2 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA5 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA21 → IFNA21 (reaction)
  • Reactome Reaction: IFNA5 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA21 → STAT2 (reaction)
  • Reactome Reaction: IFNA5 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA10 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA7 → JAK1 (reaction)
  • Reactome Reaction: IFNA16 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA1 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNAR2 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA5 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA6 → IFNA10 (reaction)
  • Reactome Reaction: IFNA5 → TYK2 (reaction)
  • Reactome Reaction: IFNAR2 → STAT1 (reaction)
  • Reactome Reaction: IFNA8 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA1 → IFNA2 (reaction)
  • Reactome Reaction: STAT1 → STAT2 (reaction)
  • Reactome Reaction: IFNB1 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA1 → IFNA14 (reaction)
  • Reactome Reaction: STAT1 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA17 → IFNB1 (reaction)
  • Reactome Reaction: IFNA4 → IFNA8 (reaction)
  • Reactome Reaction: IFNA8 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA1 → IFNA8 (reaction)
  • Reactome Reaction: IFNAR1 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA10 → JAK1 (reaction)
  • Reactome Reaction: IFNA17 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA14 → TYK2 (indirect_complex)
  • Reactome Reaction: STAT2 → TYK2 (reaction)
  • Reactome Reaction: IFNA4 → STAT2 (indirect_complex)
  • Reactome Reaction: JAK1 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA6 → IFNA6 (reaction)
  • Reactome Reaction: IFNA2 → IFNA6 (reaction)
  • Reactome Reaction: IFNA6 → STAT2 (reaction)
  • Reactome Reaction: IFNA4 → IFNA6 (reaction)
  • Reactome Reaction: IFNAR1 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA17 → IFNA21 (reaction)
  • Reactome Reaction: IFNB1 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA14 → JAK1 (reaction)
  • Reactome Reaction: IFNA6 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA8 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA2 → IFNA10 (reaction)
  • Reactome Reaction: IFNA6 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA2 → IFNB1 (reaction)
  • Reactome Reaction: IFNB1 → TYK2 (indirect_complex)
  • Reactome Reaction: STAT1 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA4 → STAT1 (reaction)
  • Reactome Reaction: IFNA4 → JAK1 (reaction)
  • Reactome Reaction: IFNB1 → TYK2 (reaction)
  • Reactome Reaction: IFNA6 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA4 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA17 → IFNA17 (reaction)
  • Reactome Reaction: IFNA2 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA10 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA6 → IFNA21 (reaction)
  • Reactome Reaction: IFNA5 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA5 → IFNB1 (reaction)
  • Reactome Reaction: IFNA5 → IFNA6 (reaction)
  • Reactome Reaction: IFNA14 → IFNA21 (reaction)
  • Reactome Reaction: IFNA6 → JAK1 (reaction)
  • Reactome Reaction: JAK1 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA7 → TYK2 (reaction)
  • Reactome Reaction: IFNA2 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA6 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA8 → STAT1 (reaction)
  • Reactome Reaction: IFNA7 → TYK2 (indirect_complex)
  • Reactome Reaction: JAK1 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNB1 → STAT2 (reaction)
  • Reactome Reaction: IFNA17 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA7 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA8 → IFNB1 (reaction)
  • Reactome Reaction: IFNA14 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA7 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA10 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA1 → IFNA7 (reaction)
  • Reactome Reaction: IFNA5 → IFNA21 (reaction)
  • Reactome Reaction: IFNAR1 → TYK2 (reaction)
  • Reactome Reaction: IFNA4 → IFNA4 (reaction)
  • Reactome Reaction: IFNA10 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA4 → IFNA17 (reaction)
  • Reactome Reaction: IFNA1 → IFNB1 (reaction)
  • Reactome Reaction: IFNA7 → IFNA16 (reaction)
  • Reactome Reaction: IFNAR1 → STAT1 (reaction)
  • Reactome Reaction: IFNA1 → IFNA6 (reaction)
  • Reactome Reaction: IFNA8 → STAT2 (reaction)
  • Reactome Reaction: IFNA1 → TYK2 (reaction)
  • Reactome Reaction: JAK1 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA14 → IFNA16 (reaction)
  • Reactome Reaction: JAK1 → JAK1 (reaction)
  • Reactome Reaction: IFNA6 → IFNA7 (reaction)
  • Reactome Reaction: IFNA14 → IFNB1 (reaction)
  • Reactome Reaction: IFNA4 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA5 → JAK1 (reaction)
  • Reactome Reaction: IFNA6 → TYK2 (reaction)
  • Reactome Reaction: TYK2 → TYK2 (reaction)
  • Reactome Reaction: IFNA5 → IFNA5 (reaction)
  • Reactome Reaction: IFNA21 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA4 → IFNA5 (reaction)
  • Reactome Reaction: IFNA7 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA10 → IFNB1 (reaction)
  • Reactome Reaction: IFNA14 → STAT1 (indirect_complex)
  • Reactome Reaction: TYK2 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA2 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA8 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA21 → STAT1 (reaction)
  • Reactome Reaction: IFNA8 → IFNA10 (reaction)
  • Reactome Reaction: IFNA6 → IFNA16 (reaction)
  • Reactome Reaction: IFNA1 → JAK1 (reaction)
  • Reactome Reaction: IFNAR1 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA2 → STAT2 (reaction)
  • Reactome Reaction: IFNA16 → JAK1 (reaction)
  • Reactome Reaction: IFNA2 → IFNA14 (reaction)
  • Reactome Reaction: IFNA1 → IFNAR1 (reaction)
  • Reactome Reaction: STAT2 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA8 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA10 → STAT1 (reaction)
  • Reactome Reaction: IFNA21 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA4 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA7 → IFNA17 (reaction)
  • Reactome Reaction: IFNA1 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA4 → IFNA21 (reaction)
  • Reactome Reaction: IFNA2 → IFNA17 (reaction)
  • Reactome Reaction: IFNA1 → STAT2 (reaction)
  • Reactome Reaction: IFNA2 → IFNA2 (reaction)
  • Reactome Reaction: IFNA1 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA14 → STAT1 (reaction)
  • Reactome Reaction: STAT2 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA1 → IFNA16 (reaction)
  • Reactome Reaction: TYK2 → STAT1 (reaction)
  • Reactome Reaction: IFNA2 → IFNA8 (reaction)
  • Reactome Reaction: IFNA17 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNB1 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA10 → IFNA17 (reaction)
  • Reactome Reaction: TYK2 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNAR1 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA1 → IFNA1 (reaction)
  • Reactome Reaction: STAT1 → TYK2 (reaction)
  • Reactome Reaction: IFNA4 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA10 → IFNAR1 (reaction)
  • Reactome Reaction: IFNB1 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA1 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA6 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA17 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA7 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA14 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA8 → IFNA21 (reaction)
  • Reactome Reaction: IFNA10 → TYK2 (reaction)
  • Reactome Reaction: IFNA16 → IFNA16 (reaction)
  • Reactome Reaction: IFNA8 → TYK2 (reaction)
  • Reactome Reaction: IFNA4 → IFNA16 (reaction)
  • Reactome Reaction: IFNA16 → STAT2 (reaction)
  • Reactome Reaction: IFNA4 → IFNAR1 (indirect_complex)
  • Reactome Reaction: STAT1 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA10 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA5 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA7 → IFNA10 (reaction)
  • Reactome Reaction: IFNA1 → TYK2 (indirect_complex)
  • Reactome Reaction: IFNA7 → IFNA8 (reaction)
  • Reactome Reaction: IFNA14 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA7 → IFNA14 (reaction)
  • Reactome Reaction: IFNA6 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA8 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA16 → STAT2 (indirect_complex)
  • Reactome Reaction: STAT2 → STAT1 (reaction)
  • Reactome Reaction: IFNA6 → IFNA17 (reaction)
  • Reactome Reaction: IFNA21 → IFNAR1 (reaction)
  • Reactome Reaction: IFNA4 → IFNA14 (reaction)
  • Reactome Reaction: IFNA14 → IFNA14 (reaction)
  • Reactome Reaction: IFNA14 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA8 → JAK1 (reaction)
  • Reactome Reaction: JAK1 → STAT2 (reaction)
  • Reactome Reaction: IFNA16 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA4 → STAT2 (reaction)
  • Reactome Reaction: STAT1 → STAT1 (reaction)
  • Reactome Reaction: IFNA14 → STAT2 (reaction)
  • Reactome Reaction: IFNA8 → IFNA16 (reaction)
  • Reactome Reaction: IFNA17 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA16 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA21 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA2 → JAK1 (reaction)
  • Reactome Reaction: IFNA2 → IFNA16 (reaction)
  • Reactome Reaction: IFNA21 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNB1 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA6 → IFNA8 (reaction)
  • Reactome Reaction: IFNA8 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNAR1 → STAT2 (reaction)
  • Reactome Reaction: IFNA10 → IFNA14 (reaction)
  • Reactome Reaction: IFNA10 → IFNA10 (reaction)
  • Reactome Reaction: IFNA14 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA16 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA8 → IFNA14 (reaction)
  • Reactome Reaction: IFNA7 → IFNA7 (reaction)
  • Reactome Reaction: IFNA1 → IFNA21 (reaction)
  • Reactome Reaction: IFNA7 → IFNAR1 (indirect_complex)
  • Reactome Reaction: IFNA21 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA8 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNB1 → STAT1 (reaction)
  • Reactome Reaction: IFNA21 → TYK2 (reaction)
  • Reactome Reaction: IFNA4 → TYK2 (reaction)
  • Reactome Reaction: IFNA17 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA8 → IFNA17 (reaction)
  • Reactome Reaction: IFNA5 → IFNA10 (reaction)
  • Reactome Reaction: JAK1 → TYK2 (reaction)
  • Reactome Reaction: IFNA14 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA6 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA2 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA17 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA4 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA5 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA6 → IFNA14 (reaction)
  • Reactome Reaction: IFNAR1 → JAK1 (reaction)
  • Reactome Reaction: IFNA16 → IFNAR2 (indirect_complex)
  • Reactome Reaction: IFNA5 → IFNA14 (reaction)
  • Reactome Reaction: IFNAR2 → IFNAR2 (reaction)
  • Reactome Reaction: IFNA1 → STAT1 (reaction)
  • Reactome Reaction: IFNA7 → STAT2 (indirect_complex)
  • Reactome Reaction: IFNA10 → STAT1 (indirect_complex)
  • Reactome Reaction: IFNA4 → IFNA10 (reaction)
  • Reactome Reaction: IFNA5 → IFNA8 (reaction)
  • Reactome Reaction: IFNA21 → JAK1 (reaction)
  • Reactome Reaction: IFNA16 → TYK2 (reaction)
  • Reactome Reaction: IFNA16 → IFNA21 (reaction)
  • Reactome Reaction: IFNA8 → IFNA8 (reaction)
  • Reactome Reaction: IFNA16 → JAK1 (indirect_complex)
  • Reactome Reaction: IFNA17 → STAT2 (reaction)
  • Reactome Reaction: IFNA10 → STAT2 (indirect_complex)
In total, 206 gene pairs are associated to this article in curated databases