UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to NGFR

NGFR — RHOA

Pathways - manually collected, often from reviews:

KEGG Neurotrophin signaling pathway: NGFR → RHOA (protein-protein, inhibition)
NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → RHOA/GTP complex (RHOA) (modification, collaborate) Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: RHOA/GTP complex (RHOA) → MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) (modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
Wang et al., Nature 2002, Yamashita et al., Nat Neurosci 2003, Mi et al., Nat Neurosci 2004
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/p75(NTR)/PKA complex (NGF-NGFR-PRKACB) → RhoA-B-C/GDP complex (RHOC_RHOA_RHOB) (modification, activates)
Yamashita et al., Neuron 1999, Higuchi et al., EMBO J 2003
Evidence: mutant phenotype, assay
Reactome Reaction: RHOA → NGFR (reaction) Yamashita et al., Nat Neurosci 2003, Keep et al., Structure 1997 *
Reactome Reaction: RHOA → NGFR (indirect_complex) Yamashita et al., Nat Neurosci 2003, Gehler et al., J Neurosci 2004 *, Keep et al., Structure 1997 *

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

STRING interaction: RHOA — NGFR (interaction, mapped from reactome)
STRING interaction: NGFR — RHOA (interaction, mapped from reactome)