Gene interactions and pathways from curated databases and text-mining
Nat Neurosci 2004, PMID: 14966521

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

Mi, Sha; Lee, Xinhua; Shao, Zhaohui; Thill, Greg; Ji, Benxiu; Relton, Jane; Levesque, Melissa; Allaire, Norm; Perrin, Steve; Sands, Bryan; Crowell, Thomas; Cate, Richard L; McCoy, John M; Pepinsky, R Blake

Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit (the neurotrophin receptor p75). However, in reconstituted non-neuronal systems, NgR1 and p75 together are unable to activate RhoA, suggesting that additional components of the receptor may exist. Here we describe LINGO-1, a nervous system-specific transmembrane protein that binds NgR1 and p75 and that is an additional functional component of the NgR1/p75 signaling complex. In non-neuronal cells, coexpression of human NgR1, p75 and LINGO-1 conferred responsiveness to oligodendrocyte myelin glycoprotein, as measured by RhoA activation. A dominant-negative human LINGO-1 construct attenuated myelin inhibition in transfected primary neuronal cultures. This effect on neurons was mimicked using an exogenously added human LINGO-1-Fc fusion protein. Together these observations suggest that LINGO-1 has an important role in CNS biology.

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Text Mining Data

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Manually curated Databases

  • IRef Bind Interaction: Complex of LINGO1-RTN4R-NGFR
  • IRef Bind Interaction: RTN4R — LINGO1
  • IRef Bind Interaction: LINGO1 — NGFR
  • IRef Bind Interaction: RTN4R — NGFR
  • IRef Bind_translation Interaction: RTN4R — LINGO1 (coimmunoprecipitation)
  • IRef Bind_translation Interaction: RTN4R — LINGO1 (unspecified method)
  • IRef Bind_translation Interaction: RTN4R — LINGO1 (experimental interaction detection)
  • IRef Bind_translation Interaction: LINGO1 — NGFR (unspecified method)
  • IRef Bind_translation Interaction: LINGO1 — NGFR (coimmunoprecipitation)
  • IRef Bind_translation Interaction: RTN4R — NGFR (unspecified method)
  • IRef Bind_translation Interaction: RTN4R — NGFR (coimmunoprecipitation)
  • MIPS CORUM LINGO-1-Nogo-66-p75 signaling complex: LINGO-1-Nogo-66-p75 signaling complex complex (LINGO1-NGFR-RTN4R)
  • IRef Corum Interaction: Complex of NGFR-NGFR-LINGO1-LINGO1-RTN4R-RTN4R (association, coimmunoprecipitation)
  • IRef Hprd Interaction: RTN4R — LINGO1 (in vitro)
  • IRef Hprd Interaction: RTN4R — LINGO1 (in vivo)
  • IRef Hprd Interaction: LINGO1 — NGFR (in vitro)
  • IRef Hprd Interaction: LINGO1 — NGFR (in vivo)
  • NCI Pathway Database p75(NTR)-mediated signaling: p75(NTR) (NGFR) → LINGO1 (LINGO1) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: p75(NTR) (NGFR) → NGR (RTN4R) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: p75(NTR) (NGFR) → MDGIs (MAG/RTN4/OMG) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: p75(NTR) (NGFR) → MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: LINGO1 (LINGO1) → NGR (RTN4R) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: LINGO1 (LINGO1) → MDGIs (MAG/RTN4/OMG) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: LINGO1 (LINGO1) → MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: NGR (RTN4R) → MDGIs (MAG/RTN4/OMG) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: NGR (RTN4R) → MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MDGIs (MAG/RTN4/OMG) → MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) (modification, collaborate)
    Evidence: mutant phenotype, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → RHOA/GTP complex (RHOA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: RHOA/GTP complex (RHOA) → MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: RHOA/GTP complex (RHOA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: RHOA/GTP complex (RHOA) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: RHOA/GTP complex (RHOA) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • NCI Pathway Database p75(NTR)-mediated signaling: None → None (modification, collaborate)
    Evidence: mutant phenotype, assay, physical interaction, other species
  • Reactome Reaction: NGFR → LINGO1 (reaction)
  • Reactome Reaction: NGFR → LINGO1 (direct_complex)
In total, 24 gene pairs are associated to this article in curated databases