Nat Neurosci 2004,
PMID: 14966521
Mi, Sha; Lee, Xinhua; Shao, Zhaohui; Thill, Greg; Ji, Benxiu; Relton, Jane; Levesque, Melissa; Allaire, Norm; Perrin, Steve; Sands, Bryan; Crowell, Thomas; Cate, Richard L; McCoy, John M; Pepinsky, R Blake
Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit (the neurotrophin receptor p75). However, in reconstituted non-neuronal systems, NgR1 and p75 together are unable to activate RhoA, suggesting that additional components of the receptor may exist. Here we describe LINGO-1, a nervous system-specific transmembrane protein that binds NgR1 and p75 and that is an additional functional component of the NgR1/p75 signaling complex. In non-neuronal cells, coexpression of human NgR1, p75 and LINGO-1 conferred responsiveness to oligodendrocyte myelin glycoprotein, as measured by RhoA activation. A dominant-negative human LINGO-1 construct attenuated myelin inhibition in transfected primary neuronal cultures. This effect on neurons was mimicked using an exogenously added human LINGO-1-Fc fusion protein. Together these observations suggest that LINGO-1 has an important role in CNS biology.
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Text Mining Data
Dashed line = No text mining data
Manually curated Databases
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IRef Bind Interaction:
Complex of LINGO1-RTN4R-NGFR
-
IRef Bind Interaction:
RTN4R
—
LINGO1
-
IRef Bind Interaction:
LINGO1
—
NGFR
-
IRef Bind Interaction:
RTN4R
—
NGFR
-
IRef Bind_translation Interaction:
RTN4R
—
LINGO1
(coimmunoprecipitation)
-
IRef Bind_translation Interaction:
RTN4R
—
LINGO1
(unspecified method)
-
IRef Bind_translation Interaction:
RTN4R
—
LINGO1
(experimental interaction detection)
-
IRef Bind_translation Interaction:
LINGO1
—
NGFR
(unspecified method)
-
IRef Bind_translation Interaction:
LINGO1
—
NGFR
(coimmunoprecipitation)
-
IRef Bind_translation Interaction:
RTN4R
—
NGFR
(unspecified method)
-
IRef Bind_translation Interaction:
RTN4R
—
NGFR
(coimmunoprecipitation)
-
MIPS CORUM LINGO-1-Nogo-66-p75 signaling complex:
LINGO-1-Nogo-66-p75 signaling complex complex (LINGO1-NGFR-RTN4R)
-
IRef Corum Interaction:
Complex of NGFR-NGFR-LINGO1-LINGO1-RTN4R-RTN4R
(association, coimmunoprecipitation)
-
IRef Hprd Interaction:
RTN4R
—
LINGO1
(in vitro)
-
IRef Hprd Interaction:
RTN4R
—
LINGO1
(in vivo)
-
IRef Hprd Interaction:
LINGO1
—
NGFR
(in vitro)
-
IRef Hprd Interaction:
LINGO1
—
NGFR
(in vivo)
-
NCI Pathway Database p75(NTR)-mediated signaling:
p75(NTR) (NGFR)
→
LINGO1 (LINGO1)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
p75(NTR) (NGFR)
→
NGR (RTN4R)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
p75(NTR) (NGFR)
→
MDGIs (MAG/RTN4/OMG)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
p75(NTR) (NGFR)
→
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
LINGO1 (LINGO1)
→
NGR (RTN4R)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
LINGO1 (LINGO1)
→
MDGIs (MAG/RTN4/OMG)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
LINGO1 (LINGO1)
→
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
NGR (RTN4R)
→
MDGIs (MAG/RTN4/OMG)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
NGR (RTN4R)
→
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MDGIs (MAG/RTN4/OMG)
→
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
(modification, collaborate)
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
→
RHOA/GTP complex (RHOA)
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
→
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA)
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
→
RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA)
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1 complex (RTN4R-NGFR-LINGO1)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
RHOA/GTP complex (RHOA)
→
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA)
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
RHOA/GTP complex (RHOA)
→
RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA)
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
RHOA/GTP complex (RHOA)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
RHOA/GTP complex (RHOA)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA)
→
RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA)
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI complex (RTN4R-NGFR-LINGO1-ARHGDIA)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA)
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
None
→
None
(modification, collaborate)
Evidence: mutant phenotype, assay, physical interaction, other species
-
Reactome Reaction:
NGFR
→
LINGO1
(reaction)
-
Reactome Reaction:
NGFR
→
LINGO1
(direct_complex)
In total, 24 gene pairs are associated to this article in curated databases