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GRAP2 — LCK

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → LAT/GRAP2/SLP76/VAV1 complex (LAT-GRAP2-LCP2-VAV1) (modification, activates)
  Reynolds et al., J Exp Med 2002, Fukazawa et al., J Biol Chem 1995, Exley et al., J Biol Chem 1994, Prasad et al., Mol Cell Biol 1993, Zhang et al., Cell 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: LAT/GRAP2/SLP76 complex (LAT-GRAP2-LCP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Liu et al., J Immunol 2000
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: LAT/GRAP2/SLP76/VAV1 complex (LAT-GRAP2-LCP2-VAV1) → TCR/CD3/MHC I/CD8/LCK complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK) (modification, collaborate)
  Reynolds et al., J Exp Med 2002, Fukazawa et al., J Biol Chem 1995, Carrera et al., J Biol Chem 1994, Exley et al., J Biol Chem 1994, de Aós et al., J Biol Chem 1997, Zhang et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: LAT/GRAP2/SLP76/VAV1/PI3K Class IA complex (LAT-GRAP2-LCP2-VAV1) → TCR/CD3/MHC I/CD8/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B-LCK-ZAP70) (modification, activates)
  Villalba et al., J Cell Biol 2002, Reynolds et al., J Biol Chem 2004
  Evidence: mutant phenotype, other species
• Reactome Reaction: GRAP2 → LCK (indirect_complex) Watanabe et al., J Immunol 2006*
• Reactome Reaction: GRAP2 → LCK (reaction) Gross et al., J Biol Chem 1999, Kim et al., Exp Mol Med 2000, Humphries et al., J Biol Chem 2004, Watanabe et al., J Immunol 2006*, Qi et al., Science's STKE : signal transduction knowledge environment 2007, Reeve et al., J Immunol 2009, Ormsby et al., Blood 2011, Bubeck Wardenburg et al., J Biol Chem 1996, Deckert et al., Immunity 1996