Gene interactions and pathways from curated databases and text-mining

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BRCA1 — SMARCE1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: BRCA1 → SMARCE1 (increases)
    Evidence: We then analyzed the effect of BAF57 depletion on the expression of endogenous ER target genes, monitoring mRNA levels by quantitative reverse transcription-PCR (QRT-PCR). The mRNA expression levels of a number of well characterized ER target genes (pS2, cathepsin D, progesterone receptor, BRCA1, BRCA2, and bcl-2) increased in ZR-75-1 cells in response to treatment with 17beta-estradiol (E2) for 24 h, as shown in Fig. 1C. The E2-dependent activation of all of these genes was markedly impaired by...

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *