Gene interactions and pathways from curated databases and text-mining
Cell 2000, PMID: 10943845

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.

Bochar, D A; Wang, L; Beniya, H; Kinev, A; Xue, Y; Lane, W S; Wang, W; Kashanchi, F; Shiekhattar, R

Germline mutations in the tumor suppressor gene, BRCA1, predispose individuals to breast and ovarian cancers. Using a combination of affinity- and conventional chromatographic techniques, we have isolated a predominant form of a multiprotein BRCA1-containing complex from human cells displaying chromatin-remodeling activity. Mass spectrometric sequencing of components of this complex indicated that BRCA1 is associated with a SWI/SNF-related complex. We show that BRCA1 can directly interact with the BRG1 subunit of the SWI/SNF complex. Moreover, p53-mediated stimulation of transcription by BRCA1 was completely abrogated by either a dominant-negative mutant of BRG1 or the cancer-causing deletion in exon 11 of BRCA1. These findings reveal a direct function for BRCA1 in transcriptional control through modulation of chromatin structure.

Diseases/Pathways annotated by Medline MESH: Breast Neoplasms
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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Bind Interaction: BRCA1 — SMARCA4
  • IRef Bind_translation Interaction: BRCA1 — SMARCA4 (affinity chromatography technology)
  • IRef Biogrid Interaction: BRCA1 — SMARCC2 (association, biochemical)
  • IRef Biogrid Interaction: BRCA1 — SMARCD2 (association, biochemical)
  • IRef Biogrid Interaction: SMARCC1 — BRCA1 (association, biochemical)
  • IRef Biogrid Interaction: BRCA1 — SMARCB1 (association, biochemical)
  • IRef Biogrid Interaction: SMARCB1 — SMARCB1 (association, biochemical)
  • IRef Biogrid Interaction: BRCA1 — SMARCA4 (direct interaction, pull down)
  • IRef Biogrid Interaction: BRCA1 — SMARCA4 (association, biochemical)
  • MIPS CORUM SWI-SNF chromatin remodeling-related-BRCA1 complex: SWI-SNF chromatin remodeling-related-BRCA1 complex complex (ACTL6A-BRCA1-SMARCA2-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD2-SMARCE1-ARID1A-ARID1B)
  • IRef Corum Interaction: Complex of 23 proteins (association, molecular sieving)
  • Gene Ontology Complexes SWI/SNF complex: SWI/SNF complex complex (SMARCC2-ARID1B-SMARCA4-ACTL6B)
  • IRef Hprd Interaction: SMARCA4 — BRCA1 (in vitro)
  • IRef Ophid Interaction: BRCA1 — SMARCA4 (aggregation, confirmational text mining)
In total, 59 gene pairs are associated to this article in curated databases