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BRCA1 — RAD51

Pathways - manually collected, often from reviews:

• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/RAD51/PCNA complex (BRCA1-BARD1-RAD51-PCNA) → RAD51 (RAD51) (modification, collaborate) Scully et al., Cell 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/RAD51/PCNA complex (BRCA1-BARD1-RAD51-PCNA) → PCNA (PCNA) (modification, collaborate) Scully et al., Cell 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: BRCA1/BARD1/RAD51/PCNA complex (BRCA1-BARD1-RAD51-PCNA) → BRCA1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
  Scully et al., Cell 1997*
  Evidence: assay, physical interaction
• NCI Pathway Database BARD1 signaling events: RAD51 (RAD51) → BRCA1/BARD1 complex (BRCA1-BARD1) (modification, collaborate)
  Scully et al., Cell 1997*
  Evidence: assay, physical interaction
• Reactome Reaction: BRCA1 → RAD51 (direct_complex) Masson et al., EMBO J 1999, Sehorn et al., Nature 2004, Oliver-Bonet et al., Mol Hum Reprod 2005, Thorslund et al., EMBO J 2007, Oliver-Bonet et al., Mol Hum Reprod 2007, Sheridan et al., Nucleic Acids Res 2008, Okorokov et al., PloS one 2010, Scully et al., Cell 1997, Barlow et al., EMBO J 1997, Golub et al., Nucleic Acids Res 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: BRCA1 — RAD51 Scully et al., Cell 1997
• IRef Bind Interaction: RAD51 — BRCA1 Scully et al., Cell 1997
• IRef Bind_translation Interaction: RAD51 — BRCA1 (coimmunoprecipitation) Scully et al., Cell 1997
• IRef Bind_translation Interaction: RAD51 — BRCA1 (affinity chromatography technology) Scully et al., Cell 1997
• IRef Bind_translation Interaction: BRCA1 — RAD51 (coimmunoprecipitation) Scully et al., Cell 1997
• IRef Bind_translation Interaction: BRCA1 — RAD51 (affinity chromatography technology) Scully et al., Cell 1997
• IRef Biogrid Interaction: BRCA1 — RAD51 (direct interaction, pull down) Chen et al., Mol Cell 1998*
• IRef Biogrid Interaction: BRCA1 — RAD51 (colocalization, imaging technique) Mok et al., Cell Signal 2010*
• IRef Biogrid Interaction: BRCA1 — RAD51 (physical association, affinity chromatography technology) Scully et al., Cell 1997
• IRef Biogrid Interaction: BRCA1 — RAD51 (direct interaction, pull down) Scully et al., Cell 1997
• IRef Biogrid Interaction: BRCA1 — RAD51 (physical association, affinity chromatography technology) Dong et al., Mol Cell 2003
• IRef Biogrid Interaction: BRCA1 — RAD51 (association, biochemical) Dong et al., Mol Cell 2003
• IRef Biogrid Interaction: BRCA1 — RAD51 (direct interaction, pull down) Wang et al., Oncogene 2001*
• MIPS CORUM BRCA1-RAD51 complex: BRCA1-RAD51 complex complex (BRCA1-RAD51) Scully et al., Cell 1997
• MIPS CORUM BRCC complex: BRCC complex complex (BRCA1-BRCA2-BRCC3-BRE-RAD51) Dong et al., Mol Cell 2003
• IRef Corum Interaction: Complex of BRCA2-BRCA1-BRCC3-BRE-RAD51 (association, affinity chromatography technology) Dong et al., Mol Cell 2003
• IRef Corum Interaction: RAD51 — BRCA1 (association, anti bait coimmunoprecipitation) Scully et al., Cell 1997
• IRef Dip Interaction: Complex of BRIP1-PALB2-BRCA2-RBBP8-RAD51-RPA1-BRCA1 (physical association, molecular sieving) Sy et al., Proc Natl Acad Sci U S A 2009
• IRef Hprd Interaction: RAD51 — BRCA1 (in vivo) Sarkisian et al., J Biol Chem 2001*, Chen et al., Mol Cell 1998*
• IRef Hprd Interaction: RAD51 — BRCA1 (in vitro) Sarkisian et al., J Biol Chem 2001*, Chen et al., Mol Cell 1998*
• IRef Hprd Interaction: Complex of 26 proteins Ryser et al., Cancer Res 2009
• IRef Hprd Interaction: RAD51 — BRCA1 (in vivo) Scully et al., Cell 1997, Chen et al., Mol Cell 1998*
• IRef Intact Interaction: Complex of 13 proteins (colocalization, cosedimentation through density gradient) Bleuyard et al., EMBO Rep 2012
• IRef Intact Interaction: Complex of H2AFX-PALB2-RAD51-MORF4L1-LMNA-BRCA1-BRCA2 (colocalization, cosedimentation through density gradient) Bleuyard et al., EMBO Rep 2012
• IRef Intact Interaction: Complex of MORF4L1-RAD51-BRCA2-BRCA1-PALB2 (association, anti tag coimmunoprecipitation) Bleuyard et al., EMBO Rep 2012
• IRef Ophid Interaction: RAD51 — BRCA1 (aggregation, confirmational text mining) Chen et al., Mol Cell 1998*
• IRef Ophid Interaction: RAD51 — BRCA1 (aggregation, confirmational text mining) Scully et al., Cell 1997
• IRef Ophid Interaction: RAD51 — BRCA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Broustas et al., J Biol Chem 2004 (Prostatic Neoplasms) : BRCC2 , a novel BH3-like domain containing protein, induces apoptosis in a caspase dependent manner
Zhou et al., Biochem Biophys Res Commun 2005 (Breast Neoplasms...) : We found that although a functional BRCA1 is required for the subnuclear assembly of BRCA1 foci following treatment with either ionizing radiation or cisplatin, a functional BRCA1 is required for RAD51 foci to form following treatment with cisplatin but not with ionizing radiation
Cousineau et al., Cancer Res 2005 (Breast Neoplasms...) : However, BRCA1 may regulate RAD51 in response to DNA damage or through its ability to interact with and regulate MRE11/RAD50/NBS1 (MRN) during the processing of DSBs into single-strand DNA ( ssDNA ) ends, prerequisite substrates for RAD51, or both ... However, BRCA1 may regulate RAD51 in response to DNA damage or through its ability to interact with and regulate MRE11/RAD50/NBS1 (MRN) during the processing of DSBs into single-strand DNA ( ssDNA ) ends, prerequisite substrates for RAD51, or both