Gene interactions and pathways from curated databases and text-mining
EMBO J 1997, PMID: 9311981

Distribution of the Rad51 recombinase in human and mouse spermatocytes.

Barlow, A L; Benson, F E; West, S C; Hultén, M A

In vitro, the human Rad51 protein (hRad51) promotes homologous pairing and strand exchange reactions suggestive of a key role in genetic recombination. To analyse its role in this process, polyclonal antibodies raised against hRad51 were used to study the distribution of Rad51 in human and mouse spermatocytes during meiosis I. In human spermatocytes, hRad51 was found to form discrete nuclear foci from early zygotene to late pachytene. The foci always co-localized with lateral element proteins, components of the synaptonemal complex (SC). During zygotene, the largest foci were present in regions undergoing synapsis, suggesting that Rad51 is a component of early recombination nodules. Pachytene nuclei showed a greatly reduced level of Rad51 labelling, with the exceptions of any asynapsed autosomes and XY segments, which were intensely labelled. The distribution of Rad51 in mouse spermatocytes was similar to that found in human spermatocytes, except that in this case Rad51 was detectable at leptotene. From these results, we conclude that the Rad51 protein has a role in the interhomologue interactions that occur during meiotic recombination. These interactions are spatially and temporally associated with synapsis during meiotic prophase I.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Reactome Reaction: DMC1 → ATM (direct_complex)
  • Reactome Reaction: H2AFX → RAD51 (indirect_complex)
  • Reactome Reaction: BRCA1 → H2AFX (indirect_complex)
  • Reactome Reaction: BRCA2 → ATM (direct_complex)
  • Reactome Reaction: BRCA2 → RAD51 (direct_complex)
  • Reactome Reaction: BRCA1 → DMC1 (direct_complex)
  • Reactome Reaction: RPA3 → HIST1H4A (indirect_complex)
  • Reactome Reaction: CDK4 → ATM (direct_complex)
  • Reactome Reaction: ATM → HIST1H4A (indirect_complex)
  • Reactome Reaction: BRCA1 → HIST1H4A (indirect_complex)
  • Reactome Reaction: BRCA1 → RPA2 (indirect_complex)
  • Reactome Reaction: BRCA1 → RPA1 (indirect_complex)
  • Reactome Reaction: RAD51 → RPA2 (indirect_complex)
  • Reactome Reaction: BRCA1 → ATM (direct_complex)
  • Reactome Reaction: HIST3H3 → RPA3 (indirect_complex)
  • Reactome Reaction: BRCA1 → CDK4 (direct_complex)
  • Reactome Reaction: RAD51 → CDK4 (direct_complex)
  • Reactome Reaction: BRCA1 → RAD51 (direct_complex)
  • Reactome Reaction: RAD51 → RPA3 (indirect_complex)
  • Reactome Reaction: BRCA2 → H2AFX (indirect_complex)
  • Reactome Reaction: BRCA2 → HIST3H3 (indirect_complex)
  • Reactome Reaction: H2AFX → RPA2 (indirect_complex)
  • Reactome Reaction: H2AFX → RPA1 (indirect_complex)
  • Reactome Reaction: DMC1 → RAD51 (direct_complex)
  • Reactome Reaction: RPA2 → HIST1H4A (indirect_complex)
  • Reactome Reaction: RAD51 → ATM (direct_complex)
  • Reactome Reaction: DMC1 → H2AFX (indirect_complex)
  • Reactome Reaction: DMC1 → HIST3H3 (indirect_complex)
  • Reactome Reaction: HIST3H3 → RPA1 (indirect_complex)
  • Reactome Reaction: HIST3H3 → RPA2 (indirect_complex)
  • Reactome Reaction: HIST3H3 → CDK4 (indirect_complex)
  • Reactome Reaction: HIST3H3 → RAD51 (indirect_complex)
  • Reactome Reaction: DMC1 → RPA1 (indirect_complex)
  • Reactome Reaction: DMC1 → CDK4 (direct_complex)
  • Reactome Reaction: HIST3H3 → ATM (indirect_complex)
  • Reactome Reaction: RAD51 → HIST1H4A (indirect_complex)
  • Reactome Reaction: BRCA2 → CDK4 (direct_complex)
  • Reactome Reaction: BRCA1 → HIST3H3 (indirect_complex)
  • Reactome Reaction: CDK4 → RPA3 (indirect_complex)
  • Reactome Reaction: BRCA1 → RPA3 (indirect_complex)
  • Reactome Reaction: BRCA1 → BRCA2 (direct_complex)
  • Reactome Reaction: BRCA2 → RPA3 (indirect_complex)
  • Reactome Reaction: RAD51 → RPA1 (indirect_complex)
  • Reactome Reaction: H2AFX → ATM (indirect_complex)
  • Reactome Reaction: BRCA2 → RPA2 (indirect_complex)
  • Reactome Reaction: H2AFX → RPA3 (indirect_complex)
  • Reactome Reaction: H2AFX → CDK4 (indirect_complex)
  • Reactome Reaction: ATM → RPA3 (indirect_complex)
  • Reactome Reaction: CDK4 → RPA1 (indirect_complex)
  • Reactome Reaction: CDK4 → RPA2 (indirect_complex)
  • Reactome Reaction: CDK4 → HIST1H4A (indirect_complex)
  • Reactome Reaction: BRCA2 → RPA1 (indirect_complex)
  • Reactome Reaction: ATM → RPA2 (indirect_complex)
  • Reactome Reaction: RPA1 → HIST1H4A (indirect_complex)
  • Reactome Reaction: BRCA2 → DMC1 (direct_complex)
  • Reactome Reaction: DMC1 → RPA3 (indirect_complex)
  • Reactome Reaction: ATM → RPA1 (indirect_complex)
  • Reactome Reaction: BRCA2 → HIST1H4A (indirect_complex)
  • Reactome Reaction: DMC1 → HIST1H4A (indirect_complex)
  • Reactome Reaction: DMC1 → RPA2 (indirect_complex)
In total, 60 gene pairs are associated to this article in curated databases