◀ Back to IL6

IL6 — SOAT1

Text-mined interactions from Literome

Flørenes et al., Oncogene 1999 (Disease Progression...) : Surprisingly, however, IL-6 stimulated STAT binding to this promoter in both sensitive and resistant cell lines ( with one exception ), suggesting that gross deregulation of this event is not the unifying cause of the defect in p21WAF1/CIP1 induction in IL-6 resistant cells
Kortylewski et al., Oncogene 1999 (Melanoma) : Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT dependent and involves upregulation of the cyclin dependent kinase inhibitor p27/Kip1
Schaefer et al., Cell Signal 2000 (Brain Neoplasms) : Interleukin-6 , leukemia inhibitory factor, and ciliary neurotrophic factor also induced Stat complexes more selectively and to a lesser magnitude than oncostatin M
Thiel et al., FEBS Lett 2000 : Termination of IL-6 induced STAT activation is independent of receptor internalization but requires de novo protein synthesis
Pratt et al., Shock 2000 (Colonic Neoplasms) : We hypothesized that in human Caco-2 cells, IL-6 acts directly through stimulation of Stat phosphorylation and that bacterial lipopolysaccharide (LPS) causes Stat activation indirectly because of its ability to cause the autocrine secretion and action of interleukin (IL)-6
Hackenmiller et al., Immunity 2000 (Immunologic Deficiency Syndromes) : Live born c-fes-/- mice exhibit lymphoid/myeloid homeostasis defects, compromised innate immunity, and increased Stat activation in response to GM-CSF and IL-6 signaling
Huss et al., J Pathol 2000 (Acute Disease...) : Although both cell lines express similar amounts of the interleukin-6 (IL-6) signal transducer gp130, the DR-transfected cells still show activation of STAT factors by IL-6 , whereas D064 cells do not
Song et al., Zhonghua Xue Ye Xue Za Zhi 2000 (Multiple Myeloma) : The biological function of IL-6 on Sko-007 cells is mediated by the activation of Jak/STAT and Ras/NF-IL-6 signal transduction pathways
Debonera et al., J Surg Res 2001 : The presence, time course, and magnitude of expression of IL-6 , STAT3 activation , and upregulation of target immediate early genes were determined in liver grafts with minimal ( < 1 h ) and prolonged ( 12 h ) cold preservation times followed by transplantation
Bode et al., Biol Chem 2001 (Carcinoma, Hepatocellular) : In this study we show that activation of p38MAPK by IL-6 acts as an inhibitory signal on IL-6 mediated activation of STAT and the alpha2-macroglobulin promoter
Song et al., Zhonghua Zhong Liu Za Zhi 2001 (Multiple Myeloma) : ( 1 ) IL-6 could promote the proliferation of U266 cells, ( 2 ) both JAK/STAT and Ras/NF-IL-6 signal transduction pathways were activated by IL-6 in the U266 cells and ( 3 ) Cell proliferation and activation of the two IL-6 signal transduction pathways were inhibited by Forskolin ; down regulating the actiration of these two signal transduction pathways at the same time
Jenab et al., Neuro Endocrinol Lett 2002 (Glioma) : The effects of interleukin-6 , leukemia inhibitory factor and interferon-gamma on STAT DNA binding and c-fos mRNA levels in cortical astrocytes and C6 glioma cells
Legendre et al., J Biol Chem 2003 : JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes
Kawano et al., Int J Hematol 2002 (MAP Kinase Signaling System...) : In both CD45- and CD45+ U-266 cells, STAT3 and MAPK(ERK1/2) can be activated in response to IL-6 equally between them, but src family kinases such as Lyn, Fyn can be activated only in CD45+ U-266 cells
Chen et al., J Virol 2003 : This in turn would establish a positive feedback loop of IL-6 induced STAT activation, LMP1 and Qp-EBNA1 expression, and viral genome persistence
Croker et al., Nat Immunol 2003 : Conversely, IL-6 induced STAT activation is normal in Socs1-deficient cells, whereas STAT1 activation induced by IFN-gamma is prolonged
Bode et al., J Immunol 2003 : Since recruitment of the tyrosine phosphatase Src homology protein tyrosine phosphatase 2 ( SHP2 ) to the signal transducing receptor subunit gp130 attenuates IL-6 mediated STAT-activation , we were interested in whether TNF-alpha also induces the association of SHP2 to the gp130 receptor subunit ... In this respect murine fibroblasts lacking exon 3 of SHP2 are not sensitive to TNF-alpha, indicating that functional SHP2 and its recruitment to gp130 are key events in inhibition of IL-6 dependent STAT activation by TNF-alpha
Wang et al., J Immunol 2003 : We also demonstrate that overexpression of SOCS-3, a protein known to inhibit STAT activation in response to IL-6 , down-regulates IL-6 induced NF-kappaB activation and ICAM-1 expression
Park et al., J Immunol 2004 : In addition, STAT3 phosphorylation in DCs was regulated by IL-6 in vivo, and STAT3 was necessary for the IL-6 suppression of bone marrow derived DC activation/maturation
Ji et al., Rheumatology (Oxford) 2005 : Inhibition was not specific for IL-10, as induction of STAT activation by IFN-gamma and IL-6 was also inhibited by 15d-PGJ2
Legendre et al., J Rheumatol 2005 (MAP Kinase Signaling System) : IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3, an aggrecan degrading enzyme and activator of pro-MMP
Kimura et al., Proc Natl Acad Sci U S A 2005 : Suppressor of cytokine signaling-1 selectively inhibits LPS induced IL-6 production by regulating JAK-STAT
Jones et al., J Infect Dis 2006 (Escherichia coli Infections...) : Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia
Radtke et al., J Cell Sci 2010 : We show that p38, activated by IL-1beta, TNFalpha or environmental stress, impairs IL-6 induced JAK/STAT signalling through phosphorylation of the common cytokine receptor subunit gp130 and its subsequent internalisation and degradation ... Consequently, inhibition of p38 or MK2, deletion of MK2 or mutation of crucial amino acids within the MK2 target site or the di-leucine internalisation motif blocks receptor depletion and restores IL-6 dependent STAT activation as well as gene induction
Lin et al., Arthritis Rheum 2010 (Arthritis, Experimental) : Ex vivo, WYE-151650 suppressed IL-2 induced STAT phosphorylation, but not IL-6 induced STAT phosphorylation, as measured in whole blood
Dittrich et al., Molecular bioSystems 2012 : Misregulated interleukin-6 (IL-6) induced Jak/STAT signaling contributes to many diseases
Russell et al., Islets 2013 : Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic ß-cells
White et al., Am J Physiol Endocrinol Metab 2013 (Cachexia...) : IL-6 suppression of mTOR activity was dependent on AMPK activation and independent of STAT signaling in myotubes
Bhat et al., J Biol Chem 1995 : The observation that AII and IL-6 utilize similar components of the STAT pathway and that AII can cross-talk with IL-6 signaling through inhibition of IL-6 induced SIF/Stat92 , implies a modulatory role for AII in cellular responses to cytokines
Seidel et al., Proc Natl Acad Sci U S A 1995 (Carcinoma, Hepatocellular...) : We have systematically examined the effects of the spacing between the TT and AA core half sites on the binding of the STAT complexes activated by IFN-gamma, interleukin (IL) 6, granulocyte-macrophage colony stimulating factor, and IL-4
Kordula et al., Biochem J 1996 : The role of Stat and C/EBP transcription factors in the synergistic activation of rat serine protease inhibitor-3 gene by interleukin-6 and dexamethasone ... In addition, long-term treatment with IL-6 results in sustained phosphorylation of APRF /Stat3
Thibault et al., FEBS Lett 1997 : Gel shift analysis of STAT nuclear factors showed activation of STAT DNA binding in nuclei of B9 cells treated with IgG anti-rat sIL-6R, whereas in H35, NIH-3T3 and M1 cells, only IL-6 could trigger a similar STAT activation
Starr et al., Nature 1997 : Expression of SOCS-1 inhibited both interleukin-6 induced receptor phosphorylation and STAT activation
Richards et al., J Immunol 1997 (Carcinoma, Hepatocellular...) : On the other hand, mCT-1 and mouse IL-6 induced strong STAT activation as well as marked increases in acute phase protein production by H35 cells
Gregory et al., J Immunol 1998 (Listeriosis) : IL-6 produced by Kupffer cells induces STAT protein activation in hepatocytes early during the course of systemic listerial infections
Sengupta et al., Proc Natl Acad Sci U S A 1998 : These results demonstrate an ERK mediated mechanism for inhibiting IL-6 induced Jak-STAT signaling that is rapid and inducible, and thus differs from previously described mechanisms for downmodulation of the Jak-STAT pathway
Lee et al., Biochem J 1999 : This study suggests that the effects of LPS on hepatic MT-I gene expression are mediated by IL-6 and involve the activation of STAT binding to the proximal promoter