UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to IL2RG

IL2RG — JAK1

Pathways - manually collected, often from reviews:

BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → PYK2 (PTK2B) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS3 (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → IRS-1 (IRS1) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
BioCarta il 2 signaling pathway: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → BCL-2 (BCL2) (modification, activates)
BioCarta il-7 signal transduction: IL-7Ra/JAK1/IL-7 complex (Il7r-JAK1-ITGA2B) → IL-7/IL-7Ra/IL-2R-gamma/JAK1 complex (ITGA2B-Il7r-IL2RG-JAK1) (modification, collaborate)
BioCarta il-7 signal transduction: IL-7Ra/JAK1/IL-7 complex (Il7r-JAK1-ITGA2B) → IL-2R-gamma (IL2RG) (modification, collaborate)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1 complex (ITGA2B-Il7r-IL2RG-JAK1) → IL-2R-gamma (IL2RG) (modification, collaborate)
BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, inhibits)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → CBL (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → SHC (SHC1) (modification, activates)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → STAT5 (STAT5A/STAT5B) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2 (IL2) → IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-IL2RA-IL2RG-JAK1-JAK3) (modification, collaborate)
BioCarta il-2 receptor beta chain in t cell activation: IL-2 (IL2) → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, collaborate)
BioCarta il-2 receptor beta chain in t cell activation: IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-IL2RA-IL2RG-JAK1-JAK3) → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, collaborate)
BioCarta il 4 signaling pathway: IRS1/2/GRB2 complex (GRB2) → IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) (modification, collaborate)
BioCarta il 4 signaling pathway: IRS1/2/GRB2 complex (GRB2) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-2R-alpha/JAK3/JAK1/IRS1/2 complex (JAK3-IL4R-IL2RG-JAK1-IL4) → GRB2 (modification, collaborate)
BioCarta il 4 signaling pathway: IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) → GRB2 (modification, collaborate)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS3 (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → Nmi/STAT5 complex (NMI-STAT5A_STAT5B) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → FYN (modification, activates)
BioCarta il 2 signaling pathway: SYK → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, collaborate)
BioCarta il 2 signaling pathway: SYK → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) (modification, collaborate)
BioCarta il 2 signaling pathway: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → LCK (modification, collaborate)
BioCarta il 2 signaling pathway: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) (modification, collaborate)
BioCarta il 2 signaling pathway: LCK → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK) (modification, collaborate)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → IL-7/IL-7Ra/IL-2R-gamma/JAK1 complex (ITGA2B-Il7r-IL2RG-JAK1) (modification, collaborate)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1 complex (ITGA2B-Il7r-IL2RG-JAK1) → JAK3 (modification, collaborate)
BioCarta il 4 signaling pathway: IL-4 (IL4) → IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R) (modification, collaborate)
BioCarta il 4 signaling pathway: IL-4 (IL4) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
BioCarta il 4 signaling pathway: IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (JAK3-JAK1-IL2RG-IL4R) → IL-4/IL-2R-gamma/IL-4R-alpha/JAK3/JAK1 complex (IL2RG-IL4-JAK3-JAK1-IL4R) (modification, collaborate)
BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) (modification, inhibits)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → CRKL (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SHP-1 (PTPN6) (modification, activates)
BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → SOCS1 (modification, activates)
BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → LCK (modification, activates)
KEGG Jak-STAT signaling pathway: CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR → JAK1/JAK2/JAK3/TYK2 (protein-protein, phosphorylation)
KEGG Measles: IL2RA/IL2RB/IL2RG → JAK1/JAK3 (protein-protein, binding/association)
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, inhibits)
Kashiwada et al., J Immunol 2001, Hanson et al., J Biol Chem 2003, Chen et al., J Immunol 2004, Pernis et al., Proc Natl Acad Sci U S A 1995, Quelle et al., Mol Cell Biol 1995, Hou et al., Science 1994, Shimoda et al., Nature 1996, Haque et al., J Biol Chem 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2R beta/JAK1/LCK/CISH complex (IL2RB-JAK1-LCK-CISH) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2R alpha (IL2RA) (modification, collaborate) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2 (IL2) (modification, collaborate) Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL2R beta/JAK1/LCK/CISH complex (IL2RB-JAK1-LCK-CISH) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → Aiolos (IKZF3) (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RasGAP/Dok-R complex (RASA1-DOK2) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SOCS3/RasGAP complex (SOCS3-RASA1) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → None (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → None (modification, activates) Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B) (modification, collaborate)
Miyazaki et al., Genes Dev 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → PYK2 (PTK2B) (modification, collaborate) Miyazaki et al., Genes Dev 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/PYK2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-PTK2B) → PYK2 (PTK2B) (modification, collaborate) Miyazaki et al., Genes Dev 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
Augustine et al., Mol Cell Biol 1991, Gómez et al., J Immunol 1997
Evidence: assay, other species
NCI Pathway Database IL2 signaling events mediated by PI3K: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PKC zeta (PRKCZ) (modification, activates) Gómez et al., Exp Cell Res 1995, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL4-mediated signaling events: BCL6 (BCL6) → IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) (T-helper 2 cell differentiation, inhibits)
Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) → STAT6 (dimer) complex (STAT6) (T-helper 2 cell differentiation, activates)
Wurster et al., Mol Cell Biol 2002, Swain et al., J Immunol 1990, Shimoda et al., Nature 1996, Kaplan et al., Immunity 1996, Dent et al., Science 1997, Dent et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, other species
NCI Pathway Database IL4-mediated signaling events: ETS1 (ETS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Travagli et al., J Biol Chem 2004
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: STAT6 (dimer) complex (STAT6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Travagli et al., J Biol Chem 2004
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → SHC (SHC1) (modification, collaborate) Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → SHC (SHC1) (modification, collaborate) Burns et al., J Biol Chem 1993, Ravichandran et al., J Biol Chem 1994, Ravichandran et al., Proc Natl Acad Sci U S A 1996, Friedmann et al., Proc Natl Acad Sci U S A 1996, Lord et al., J Immunol 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK complex (IL2RB-JAK1-LCK) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2 (IL2) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., FEBS Lett 1999, Tsujino et al., Genes Cells 1999, Tsujino et al., Proc Natl Acad Sci U S A 2000, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, González-García et al., J Biol Chem 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: SHP1 (PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6) (modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
NCI Pathway Database IL4-mediated signaling events: SHP1 (PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-PTPN6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Kashiwada et al., J Immunol 2001, Imani et al., J Biol Chem 1997
Evidence: assay, physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
Jiang et al., J Immunol 2001, Wurster et al., Mol Cell Biol 2002, Sun et al., Nature 1995, Izuhara et al., Blood 1996
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1) → IRS1 (IRS1) (modification, collaborate) Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL4-mediated signaling events: IRS1 (IRS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Johnston et al., J Biol Chem 1995, Keegan et al., Cell 1994
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) → PKC beta (PRKCB) (modification, activates) Gómez et al., Exp Cell Res 1995
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → Dok-R (DOK2) (modification, activates) Nelms et al., Immunity 1998
NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database SHP2 signaling: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database SHP2 signaling: RHOA/GTP complex (RHOA) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: STAT1 (STAT1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., Eur J Immunol 2000, Frank et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995
Evidence: assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT1 (dimer) complex (STAT1) (modification, activates)
Delespine-Carmagnat et al., Eur J Immunol 2000, Frank et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995
Evidence: assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1-PIK3CA-PIK3R1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: GRB2 (GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2) (modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: GRB2 (GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D-GRB2) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
Wery et al., J Biol Chem 1996
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) (modification, collaborate)
Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → GAB2/GRB2/SOS1 complex (GRB2-SOS1-GAB2) (modification, collaborate)
Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → GAB2/GRB2/SOS1 complex (GRB2-SOS1-GAB2) (modification, collaborate)
Gu et al., Mol Cell Biol 2000, Zhu et al., J Biol Chem 1994, Ravichandran et al., J Biol Chem 1994
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SHP2 (PTPN11) (modification, collaborate) Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/ERK1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-MAPK3_MAPK1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Arnaud et al., J Immunol 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) (modification, collaborate)
Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → IRS2 (IRS2) (modification, collaborate) Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES-IRS2) → IRS2 (IRS2) (modification, collaborate) Jiang et al., J Immunol 2001, Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: SOCS5 (SOCS5) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, inhibits)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Seki et al., Proc Natl Acad Sci U S A 2002, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D) (modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Kashiwada et al., J Immunol 2001, Zamorano et al., J Immunol 1998
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2) → Dok-R (DOK2) (modification, collaborate) Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/Dok-R complex (IL4-IL4R-JAK1-IL2RG-JAK3-DOK2) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL4-mediated signaling events: Dok-R (DOK2) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL4-mediated signaling events: STAT6 (dimer) complex (STAT6) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Sherman et al., J Immunol 1999
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, inhibits)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT5 (STAT5A/STAT5B) (modification, activates) Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT5 (dimer)-active (STAT5B/STAT5A) (modification, activates)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) (modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3/PI3K complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Augustine et al., Mol Cell Biol 1991
Evidence: assay, other species
NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
Gu et al., Mol Cell Biol 2000, Lindemann et al., J Biol Chem 2003, Akbar et al., Eur J Immunol 1996, Ahmed et al., Proc Natl Acad Sci U S A 1997, Reif et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R beta/gamma/JAK1/LCK/JAK3 complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3) (modification, collaborate)
Tsujino et al., Genes Cells 1999, Merida et al., J Immunol 1991, Taichman et al., J Biol Chem 1993, González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → SHP2 (PTPN11) (modification, collaborate) Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: RHOA/GTP complex (RHOA) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, activates)
Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
Gadina et al., J Biol Chem 2000, Arnaud et al., Biochem J 2004, Gadina et al., J Immunol 1998, Gadina et al., J Immunol 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2 (IL2) (modification, collaborate) Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R beta/gamma/JAK1/Fyn/JAK3 complex (IL2RB-JAK1-FYN-IL2-IL2RG-JAK3) → IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN) (modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL2R beta/JAK1/Fyn complex (IL2RB-JAK1-FYN) (modification, collaborate)
Kobayashi et al., Proc Natl Acad Sci U S A 1993
Evidence: assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IRS1-2 (IRS2/IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IRS1-2 (IRS2/IRS1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/IRS1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-IRS2_IRS1) (modification, collaborate)
Johnston et al., J Biol Chem 1995
Evidence: physical interaction
NCI Pathway Database IL2-mediated signaling events: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 complex (IL4-IL4R-JAK1-IL2RG-JAK3-IRS1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
Johnston et al., J Biol Chem 1995, Sun et al., Nature 1995
Evidence: assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: SYK (SYK) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: SYK (SYK) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK) (modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK) (modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL2R gamma/JAK3 complex (IL2RG-JAK3) (modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1 complex (IL4-IL4R-JAK1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: SOCS1 (SOCS1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, inhibits)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL2R gamma/JAK3 complex (IL2RG-JAK3) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Losman et al., J Immunol 1999, Haque et al., J Biol Chem 2000, Hanson et al., J Biol Chem 2003, Kühn et al., Science 1991, Smerz-Bertling et al., J Biol Chem 1995, Russell et al., Science 1994, Seldin et al., Proc Natl Acad Sci U S A 1994, Koettnitz et al., Eur J Immunol 1993, Wang et al., Immunity 1996, Noben-Trauth et al., Proc Natl Acad Sci U S A 1997, Letzelter et al., Eur J Biochem 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → p38alpha-beta-active (MAPK14/MAPK11) (modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1) → p38alpha-beta (MAPK14/MAPK11) (modification, activates)
Hunt et al., J Biol Chem 1999, Crawley et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
Jiang et al., Blood 2003
Evidence: mutant phenotype
NCI Pathway Database IL2-mediated signaling events: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → RHOA/GTP complex (RHOA) (modification, activates) Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → RHOA/GDP complex (RHOA) (modification, activates) Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → None (modification, activates) Gómez et al., J Immunol 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL4-mediated signaling events: STAT5 (STAT5A/STAT5B) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Mora et al., J Immunol 2001
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: PP2A (PPP2R5D) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (positive regulation of cell-cell adhesion, collaborate)
Brockdorff et al., Cytokine 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → FES (FES) (modification, collaborate) Jiang et al., J Immunol 2001
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/FES complex (IL4-IL4R-JAK1-IL2RG-JAK3-FES) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
NCI Pathway Database IL4-mediated signaling events: FES (FES) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Jiang et al., J Immunol 2001
Evidence: physical interaction
NCI Pathway Database SHP2 signaling: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
Evidence: mutant phenotype
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/STAM1-2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-STAM2_STAM) → STAM1-2 (STAM2/STAM) (modification, collaborate) Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAM1-2 (STAM2/STAM) (modification, collaborate) Endo et al., FEBS Lett 2000, Takeshita et al., Immunity 1997
Evidence: mutant phenotype, physical interaction
NCI Pathway Database IL2 signaling events mediated by PI3K: IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K complex (IL2RB-JAK1-LCK-IL2-IL2RG-JAK3-PIK3CA-PIK3R1) → BCL-X (BCL2L1) (transcription, activates) González-García et al., J Biol Chem 1997
Evidence: mutant phenotype, other species
NCI Pathway Database IL2-mediated signaling events: STAT3 (STAT3) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) (modification, collaborate)
Delespine-Carmagnat et al., Eur J Immunol 2000, Fung et al., Cell Signal 2003, Nielsen et al., Eur J Immunol 1994, Frank et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Ng et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → MEK1-2 (MAP2K1/MAP2K2) (modification, activates) Delespine-Carmagnat et al., Eur J Immunol 2000, Fung et al., Cell Signal 2003, Nielsen et al., Eur J Immunol 1994, Frank et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Ng et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database IL4-mediated signaling events: CD40LG (CD40LG) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (transcription, activates)
Gupta et al., J Exp Med 1999
NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) (modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: SHIP (INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) → SHC (SHC1) (modification, collaborate) Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP complex (IL4-IL4R-JAK1-IL2RG-JAK3-SHC1-INPP5D) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
NCI Pathway Database IL4-mediated signaling events: SHC (SHC1) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
Crowley et al., J Biol Chem 1996, Wery et al., J Biol Chem 1996
Evidence: physical interaction, other species
Reactome Reaction: IL2RG → JAK1 (reaction) Zhou et al., Mol Cell Biol 2000, Rickert et al., J Mol Biol 2004, Stauber et al., Proc Natl Acad Sci U S A 2006, Johnston et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Nature 1994, Kondo et al., Science 1994 *, Noguchi et al., Science 1993 *, Friedmann et al., Proc Natl Acad Sci U S A 1996
Reactome Reaction: IL2RG → JAK1 (indirect_complex) Zhou et al., Mol Cell Biol 2000, Rickert et al., J Mol Biol 2004, Stauber et al., Proc Natl Acad Sci U S A 2006, Johnston et al., Nature 1994, Kondo et al., Science 1994 *, Noguchi et al., Science 1993 *, Friedmann et al., Proc Natl Acad Sci U S A 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: IL2RG — JAK1 (physical association, affinity chromatography technology) Tanaka et al., Proc Natl Acad Sci U S A 1994 *
IRef Hprd Interaction: IL2RG — JAK1 (in vivo) Russell et al., Science 1994