◀ Back to RAC1
BRK1 — RAC1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
RAC1
→
BRK1
(reaction)
Suetsugu et al., J Cell Biol 2006, Miki et al., EMBO J 1998
-
Reactome Reaction:
RAC1
→
BRK1
(indirect_complex)
Leng et al., Proc Natl Acad Sci U S A 2005, Suetsugu et al., J Cell Biol 2006, Nakanishi et al., J Biochem 2007, Mendoza et al., Mol Cell 2011, Miki et al., EMBO J 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Miki et al., Biochem Biophys Res Commun 2002
:
Interestingly, the intramolecular interaction is interrupted by the binding of WAVE2 and full-length IRSp53 associates with
Rac in the
presence of
WAVE2
Oikawa et al., Nat Cell Biol 2004
:
Production of PtdIns ( 3,4,5 ) P ( 3 ) at the cell membrane by myristoylated phosphatidylinositol-3-OH kinase ( PI(3)K ) is sufficient to recruit
WAVE2 in the
presence of dominant negative
Rac and latrunculin, demonstrating that PtdIns ( 3,4,5 ) P ( 3 ) alone is able to recruit WAVE2
Suetsugu et al., J Cell Biol 2006
:
Purified
WAVE2 and purified WAVE2 complex were activated by IRSp53 in a
Rac dependent manner with PIP ( 3 ) -containing liposomes ... Therefore, IRSp53 optimizes the activity of the
WAVE2 complex in the
presence of activated
Rac and PIP ( 3 )
Harmon et al., PLoS Pathog 2010
(Astrocytoma...) :
Rac and the tyrosine kinase Abl then
activate the
Wave2 complex and promote Arp2/3 dependent actin polymerization