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CTNNB1 — IQGAP1

Pathways - manually collected, often from reviews:

• KEGG Adherens junction: IQGAP1 → CTNNB1 (protein-protein, inhibition)
• NCI Pathway Database CDC42 signaling events: E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) → E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CDC42 signaling events: E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) → IQGAP1 (IQGAP1) (modification, collaborate) Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CDC42 signaling events: E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) → CDC42/GTP/IQGAP1 complex (CDC42-IQGAP1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CDC42 signaling events: alpha catenin (CTNNA1) → E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CDC42 signaling events: E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) → None (modification, collaborate) Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CDC42 signaling events: E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) → IQGAP1 (IQGAP1) (modification, collaborate) Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database RAC1 signaling pathway: E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) → E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database RAC1 signaling pathway: E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) → RAC1/GTP/IQGAP1 complex (RAC1-IQGAP1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database RAC1 signaling pathway: E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) → IQGAP1 (IQGAP1) (modification, collaborate) Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database RAC1 signaling pathway: alpha catenin (CTNNA1) → E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database RAC1 signaling pathway: E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) → None (modification, collaborate) Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database RAC1 signaling pathway: E-cadherin/beta catenin/IQGAP1 complex (CDH1-CTNNB1-IQGAP1) → IQGAP1 (IQGAP1) (modification, collaborate) Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: E-cadherin/Ca2+/beta catenin/IQGAP1/p120 catenin complex (CDH1-CTNNB1-CTNND1) → IQGAP1 (IQGAP1) (modification, collaborate) Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: physical interaction
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: IQGAP1 (IQGAP1) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: physical interaction
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) → RAC1-CDC42/GTP/IQGAP1 complex (RAC1_CDC42-IQGAP1) (modification, collaborate)
  Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1) → IQGAP1 (IQGAP1) (modification, collaborate) Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1) → VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1) (modification, collaborate)
  Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: IQGAP1 (IQGAP1) → VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1) (modification, collaborate)
  Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1) (modification, collaborate)
  Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — IQGAP1 (direct interaction, pull down) Briggs et al., J Biol Chem 2002*
• Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3) Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
• IRef Hprd Interaction: CTNNB1 — IQGAP1 (in vitro) Briggs et al., J Biol Chem 2002*, Li et al., J Biol Chem 2003*, Emadali et al., Mol Cell Proteomics 2006*
• IRef Hprd Interaction: CTNNB1 — IQGAP1 (in vivo) Briggs et al., J Biol Chem 2002*, Li et al., J Biol Chem 2003*, Emadali et al., Mol Cell Proteomics 2006*
• IRef Innatedb Interaction: Complex of IQGAP1-CALM1-CTNNB1 (unknown, -) Briggs et al., J Biol Chem 2002*
• IRef Intact Interaction: Complex of YAP1-IQGAP1-CDH1-CTNNA1-CTNND1-CTNNA2-CDH3-CTNNB1 (association, anti bait coimmunoprecipitation) Schlegelmilch et al., Cell 2011
• IRef Intact Interaction: CTNNB1 — IQGAP1 (physical association, anti bait coimmunoprecipitation) Rigothier et al., PloS one 2012*
• IRef Intact Interaction: CTNNB1 — IQGAP1 (colocalization, confocal microscopy) Rigothier et al., PloS one 2012*
• IRef Ophid Interaction: CTNNB1 — IQGAP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Fukata et al., Mol Cell Biol 2001 : We have previously proposed that IQGAP1 , an effector of Rac1 and Cdc42, negatively regulates cadherin mediated cell-cell adhesion by interacting with beta-catenin and by causing the dissociation of alpha-catenin from cadherin-beta-catenin-alpha-catenin complexes and that activated Rac1 and Cdc42 positively regulate cadherin mediated cell-cell adhesion by inhibiting the interaction of IQGAP1 with beta-catenin
Sugimoto et al., J Hum Genet 2001 (Stomach Neoplasms) : IQGAP1 has been reported to encode a ras GAP related protein, and its interaction with cadherin and/or beta-catenin induces a dissociation of beta-catenin from the cadherin-catenin complex, one of the mechanisms for cell-cell adhesion
Briggs et al., J Biol Chem 2002 : The recently discovered calmodulin binding protein IQGAP1 binds stoichiometrically to beta-catenin and regulates the association of beta-catenin with the cell-cell adhesion complex
Noritake et al., Mol Biol Cell 2004 : We here found that suppression of IQGAP1 , an actin binding protein and an effector of Rac1, by small interfering RNA apparently reduced the accumulation of actin filaments, E-cadherin, and beta-catenin at sites of cell-cell contact in Madin-Darby canine kidney II epithelial cells under the conditions in which knockdown of Rac1 reduced them
Sharma et al., J Biol Chem 2007 : Transient overexpression of IQGAP1 or N-cadherin increased beta-catenin at membrane ruffles