Gene interactions and pathways from curated databases and text-mining
Cell 2004, PMID: 14718166

Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis.

Tagami, Hideaki; Ray-Gallet, Dominique; Almouzni, Geneviève; Nakatani, Yoshihiro

Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3 are deposited into chromatin through distinct pathways, we have purified deposition machineries for these histones. The H3.1 and H3.3 complexes contain distinct histone chaperones, CAF-1 and HIRA, that we show are necessary to mediate DNA-synthesis-dependent and -independent nucleosome assembly, respectively. Notably, these complexes possess one molecule each of H3.1/H3.3 and H4, suggesting that histones H3 and H4 exist as dimeric units that are important intermediates in nucleosome formation. This finding provides new insights into possible mechanisms for maintenance of epigenetic information after chromatin duplication.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: ASF1B — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HAT1 — H3F3A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HIST1H4A — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IPO4 — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: H3F3A — NASP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CHAF1A — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HAT1 — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I — NASP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I — ASF1A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: H3F3A — RBBP4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CHAF1B — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: IPO4 — H3F3A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: H3F3A — ASF1B (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HIST1H4A — H3F3A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RBBP4 — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I — HIST1H3B, HIST1H3C, HIST1H3A, HIST1H3F, HIST1H3G, HIST1H3D, HIST1H3E, HIST1H3J, HIST1H3H, HIST1H3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: H3F3A — HIRA (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: H3F3A — ASF1A (physical association, affinity chromatography technology)
  • MIPS CORUM Histone H3.1 complex: Histone H3.1 complex complex (ASF1A-ASF1B-CHAF1A-CHAF1B-HAT1-HIST1H3B-HIST1H3C-HIST1H3A-HIST1H3F-HIST1H3G-HIST1H3D-HIST1H3E-HIST1H3J-HIST1H3H-HIST1H3I-HIST1H4C-HIST1H4B-HIST1H4A-HIST4H4-HIST1H4F-HIST1H4E-HIST1H4D-HIST1H4K-HIST1H4J-HIST1H4I-HIST1H4H-HIST1H4L-HIST2H4B-HIST2H4A-IPO4-NASP-RBBP4)
  • MIPS CORUM Histone H3.3 complex: Histone H3.3 complex complex (ASF1A-ASF1B-H3F3B-H3F3A-HAT1-HIRA-HIST1H4C-HIST1H4B-HIST1H4A-HIST4H4-HIST1H4F-HIST1H4E-HIST1H4D-HIST1H4K-HIST1H4J-HIST1H4I-HIST1H4H-HIST1H4L-HIST2H4B-HIST2H4A-IPO4-NASP-RBBP4)
  • IRef Corum Interaction: Complex of ASF1B-IPO4-RBBP4-H3F3A-HIST1H4A-HIRA-HAT1-NASP-ASF1A (association, coimmunoprecipitation)
  • IRef Corum Interaction: Complex of 20 proteins (association, coimmunoprecipitation)
  • Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
  • IRef Hprd Interaction: HIST3H3 — ASF1A (in vitro)
  • IRef Hprd Interaction: HIST3H3 — ASF1A (in vivo)
In total, 21470 gene pairs are associated to this article in curated databases