◀ Back to NFKB1
BCL3 — NFKB1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Atypical NF-kappaB pathway:
NF kappa B1 p50 dimer complex (NFKB1)
→
BCL3 (BCL3)
(modification, collaborate)
Wulczyn et al., Nature 1992*, Fujita et al., Genes Dev 1993*, Franzoso et al., EMBO J 1993*
Evidence: assay, physical interaction
-
NCI Pathway Database Atypical NF-kappaB pathway:
NF kappa B1 p50 dimer complex (NFKB1)
→
BCL3/NF kappa B1 p50 complex (BCL3-NFKB1)
(modification, collaborate)
Wulczyn et al., Nature 1992*, Fujita et al., Genes Dev 1993*, Franzoso et al., EMBO J 1993*
Evidence: assay, physical interaction
-
NCI Pathway Database Atypical NF-kappaB pathway:
BCL3 (BCL3)
→
BCL3/NF kappa B1 p50 complex (BCL3-NFKB1)
(modification, collaborate)
Wulczyn et al., Nature 1992*, Fujita et al., Genes Dev 1993*, Franzoso et al., EMBO J 1993*
Evidence: assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
NFKB1
—
BCL3
Viatour et al., Mol Cell 2004*
-
IRef Bind Interaction:
NFKB1
—
BCL3
Kim et al., Nature 2005
-
IRef Bind_translation Interaction:
NFKB1
—
BCL3
(coimmunoprecipitation)
Kim et al., Nature 2005
-
IRef Bind_translation Interaction:
NFKB1
—
BCL3
(coimmunoprecipitation)
Viatour et al., Mol Cell 2004*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(physical association, affinity chromatography technology)
Barré et al., EMBO J 2007
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(physical association, affinity chromatography technology)
Thornburg et al., Cancer Res 2003*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(colocalization, imaging technique)
Thornburg et al., Cancer Res 2003*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(direct interaction, pull down)
Naumann et al., EMBO J 1993*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(association, biochemical)
Naumann et al., EMBO J 1993*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(physical association, affinity chromatography technology)
Naumann et al., EMBO J 1993*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(direct interaction, pull down)
Heissmeyer et al., EMBO J 1999*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(physical association, affinity chromatography technology)
Keutgens et al., Mol Cell Biol 2010*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(physical association, affinity chromatography technology)
Keutgens et al., J Biol Chem 2010*
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(physical association, affinity chromatography technology)
Kim et al., Nature 2005
-
IRef Biogrid Interaction:
BCL3
—
NFKB1
(physical association, affinity chromatography technology)
Choi et al., Biochem Biophys Res Commun 2010*
-
Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
-
IRef Hprd Interaction:
Complex of NFKB1-NFKB1-TP53-BCL3-BCL3-TP53-NFKB1-TP53-BCL3
(in vivo)
Thornburg et al., Cancer Res 2003*
-
IRef Hprd Interaction:
BCL3
—
NFKB1
(in vivo)
Dechend et al., Oncogene 1999*, Thornburg et al., Cancer Res 2003*, Barré et al., EMBO J 2007, Naumann et al., EMBO J 1993*
-
IRef Hprd Interaction:
BCL3
—
NFKB1
(two hybrid)
Dechend et al., Oncogene 1999*, Thornburg et al., Cancer Res 2003*, Barré et al., EMBO J 2007, Naumann et al., EMBO J 1993*
-
IRef Hprd Interaction:
BCL3
—
NFKB1
(in vitro)
Dechend et al., Oncogene 1999*, Thornburg et al., Cancer Res 2003*, Barré et al., EMBO J 2007, Naumann et al., EMBO J 1993*
-
IRef Innatedb Interaction:
NFKB1
—
BCL3
(unknown, -)
Nishikori et al., Cancer Sci 2005*
-
IRef Innatedb Interaction:
NFKB1
—
BCL3
(unknown, -)
Uffort et al., J Invest Dermatol 2009*
-
IRef Intact Interaction:
Complex of RELB-NFKB1-NFKB2-REL-SIN3A-RELA-BCL3
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of NFKB2-RELA-NFKB2-SIN3A-BCL3-NFKB1
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of NFKB1-RELB-SIN3A-NFKB2-NFKB2-BCL3
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of BCL3-NFKB1-NFKB2-REL-SIN3A-RELA-NFKB2-RELB
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of REL-NFKB1-NFKB2-BCL3-SIN3A-NFKB2
(association, anti bait coimmunoprecipitation)
Barré et al., EMBO J 2007
-
IRef Ophid Interaction:
NFKB1
—
BCL3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Badrichani et al., J Clin Invest 1999
:
In addition, Bcl-2 or
Bcl-XL inhibits activation of
NF-kappaB and thus upregulation of proinflammatory genes
Bertin et al., J Biol Chem 2000
:
Although its role in apoptosis remains to be determined,
BCL10 likely
activates NF-kappaB through the IKK complex in response to upstream stimuli
Brasier et al., J Biol Chem 2001
:
Down-regulation of
BCL-3 induction
results in prolonged, enhanced
NF-kappa B1 binding and increased NF-kappa B-dependent transcription
Rocha et al., Mol Cell Biol 2003
:
p53 represses cyclin D1 transcription through down regulation of
Bcl-3 and
inducing increased association of the p52
NF-kappaB subunit with histone deacetylase 1
Corn et al., J Immunol 2003
:
Further, induced expression of
Bcl-3 , a trans activating IkappaB-like protein, is decreased in T cells as a
consequence of
NF-kappaB inhibition
Yorke et al., Eur J Cancer 2003
(Adenocarcinoma...) :
Receptor activator of
NF-kappaB ( RANK ) activation
induces several survival signals including nuclear factor kappaB (NF-kappaB) and activation and upregulation of
Bcl-xL
Ge et al., J Immunol 2003
:
NF-kappa B regulates
BCL3 transcription in T lymphocytes through an intronic enhancer ... Together, these results demonstrate a critical
role for
NF-kappaB in
BCL3 transcriptional up-regulation by TCR-mimetic signals
Chen et al., Apoptosis 2004
(Colonic Neoplasms) :
Bcl-2, and to the less extent,
Bcl-xL , were able to
increase the activity of
NF-kappa B , which was a known anti-apoptotic molecule in human colon cancer cells
Tran et al., J Biol Chem 2005
(Astrocytoma...) :
In addition, Fn14 activation induced
BCL-XL and BCL-W mRNA and protein levels, and this effect was
dependent upon
NFkappaB transcriptional activity ... Our results suggest that
NFkappaB mediated up-regulation of BCL-XL and
BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy induced apoptosis
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
Furthermore,
BCL10 and cIAP2-MALT1 synergistically
activate NF-kappaB
Tao et al., Mol Cell Biol 2006
:
Up-regulation of proapoptotic protein
Bcl-XS and neuronal apoptosis induced by serum deprivation are
blocked by inhibition and/or down-regulation of
NF-kappaB and by prevention of K+ loss
Massoumi et al., Cell 2006
(Skin Neoplasms) :
Cyld inhibits tumor cell proliferation by blocking
Bcl-3 dependent
NF-kappaB signaling
Khanbolooki et al., Mol Cancer Ther 2006
(Pancreatic Neoplasms) :
NF-kappaB inhibition
resulted in down-regulation of
BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Deeb et al., J Pharmacol Exp Ther 2007
(Prostatic Neoplasms) :
Because expression of antiapoptotic Bcl-2,
Bcl-xL , and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is
regulated by
NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
de Kozak et al., Am J Pathol 2007
(Inflammation...) :
At 24 hours after lipopolysaccharide stimulation, nuclear NF-kappaB/p65 decreased and nuclear
NF-kappaB/p50 increased , associated with nuclear
BCL-3 and a low level of TNF-alpha, indicating onset of spontaneous resolution
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2,
Bcl-xL , cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Takase et al., Kidney Int 2008
(Chronic Disease...) :
Inhibition of
NF-kappaB dependent
Bcl-xL expression by clusterin promotes albumin induced tubular cell apoptosis
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
A signal network
involving coactivated
NF-kappaB and STAT3 and altered p53 modulates
BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Aimbire et al., Int Immunopharmacol 2008
(Inflammation) :
LLLT and an inhibitor of
NF-kappaB nuclear translocation ( BMS 205820 )
attenuated the mRNA levels of
Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS induced inflammation
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009
(Adenocarcinoma...) :
NFkappaB DNA binding activity and
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes were also prevented by DHA and EPA treatment ... Finally, we showed that PTEN expression significantly inhibited
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes
Patel et al., J Leukoc Biol 2009
(Disease Susceptibility...) :
IL-10 did not influence p-IRAK, IkappaB degradation, or NF-kappaB p65 nuclear translocation in response to MTb, but IL-10 did increase levels of AM
BCL-3 , an
inhibitor of
NF-kappaB nuclear activity
Banerjee et al., Cancer Res 2009
(Pancreatic Neoplasms) :
Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced
activation of
NF-kappaB and its downstream genes (
Bcl-xL , XIAP, cIAP, and survivin )
Zhang et al., Mol Cell Biol 1994
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
In contrast to I kappa B alpha ( MAD3 ),
BCL3 does not
cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50
Nolan et al., Mol Cell Biol 1993
:
At concentrations that significantly inhibited DNA binding by homodimeric p50,
Bcl-3 did not
inhibit binding of reconstituted heterodimeric
NF-kappa B ( p50 : p65 ), a DNA binding homodimeric form of p65, or homodimers of c-Rel
Bundy et al., J Biol Chem 1997
:
Diverse
effects of
BCL3 phosphorylation on its modulation of
NF-kappaB p52 homodimer binding to DNA