UCSC Genome Browser Gene Interaction Graph

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to LMNA

LMNA — LMNB1

Pathways - manually collected, often from reviews:

BioCarta caspase cascade in apoptosis: Caspase 2 (CASP2) → Lamin A/C/Lamin B1/Lamin B2 (cleaved) complex (LMNA-LMNB2-LMNB1) (modification, activates)
BioCarta caspase cascade in apoptosis: Caspase 2 (CASP2) → Lamin A/C/Lamin B1/Lamin B2 complex (LMNB1-LMNA-LMNB2) (modification, activates)
BioCarta caspase cascade in apoptosis: Lamin A/C/Lamin B1/Lamin B2 (cleaved) complex (LMNA-LMNB2-LMNB1) → Lamin A/C/Lamin B1/Lamin B2 complex (LMNB1-LMNA-LMNB2) (modification, collaborate)
BioCarta tnfr1 signaling pathway: Caspase 2 (active) (CASP2) → Lamin A/C/Lamin B1/Lamin B2 (cleaved) complex (LMNA-LMNB2-LMNB1) (modification, activates)
BioCarta tnfr1 signaling pathway: Caspase 2 (active) (CASP2) → Lamin A/C/Lamin B1/Lamin B2 complex (LMNB1-LMNA-LMNB2) (modification, activates)
BioCarta tnfr1 signaling pathway: Lamin A/C/Lamin B1/Lamin B2 (cleaved) complex (LMNA-LMNB2-LMNB1) → Lamin A/C/Lamin B1/Lamin B2 complex (LMNB1-LMNA-LMNB2) (modification, collaborate)
BioCarta tnfr1 signaling pathway: Caspase 2b (CASP2) → Lamin A/C/Lamin B1/Lamin B2 complex (LMNB1-LMNA-LMNB2) (modification, inhibits)
BioCarta caspase cascade in apoptosis: Caspase 6 (active) (CASP6) → Lamin A/C/Lamin B1/Lamin B2 (cleaved) complex (LMNA-LMNB2-LMNB1) (modification, activates)
BioCarta caspase cascade in apoptosis: Caspase 6 (active) (CASP6) → Lamin A/C/Lamin B1/Lamin B2 complex (LMNB1-LMNA-LMNB2) (modification, activates)
BioCarta caspase cascade in apoptosis: Lamin A/C/Lamin B1/Lamin B2 (cleaved) complex (LMNA-LMNB2-LMNB1) → Lamin A/C/Lamin B1/Lamin B2 complex (LMNB1-LMNA-LMNB2) (modification, collaborate)
NCI Pathway Database Caspase Cascade in Apoptosis: Lamins (LMNA/LMNB2/LMNB1) → Lamins (cleaved) (LMNA/LMNB2/LMNB1) (modification, collaborate)
Ruchaud et al., EMBO J 2002
Evidence: assay
NCI Pathway Database Caspase Cascade in Apoptosis: Lamins (LMNA/LMNB2/LMNB1) → Lamins (cleaved) (LMNA/LMNB2/LMNB1) (modification, collaborate)
Ruchaud et al., EMBO J 2002
Evidence: assay
Reactome Reaction: LMNB1 → LMNA (direct_complex) Scherthan et al., J Cell Biol 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind Interaction: LMNA — LMNB1 Ye et al., Exp Cell Res 1995 *
IRef Bind_translation Interaction: LMNA — LMNB1 (two hybrid) Ye et al., Exp Cell Res 1995 *
IRef Biogrid Interaction: LMNA — LMNB1 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
IRef Biogrid Interaction: LMNA — LMNB1 (physical association, affinity chromatography technology) Ju et al., Beijing Da Xue Xue Bao 2009
IRef Biogrid Interaction: LMNA — LMNB1 (physical association, proximity labelling technology) Roux et al., J Cell Biol 2012
IRef Biogrid Interaction: LMNA — LMNB1 (physical association, affinity chromatography technology) Liu et al., Nature 2011 *
IRef Biogrid Interaction: LMNA — LMNB1 (direct interaction, two hybrid) Ostlund et al., J Cell Sci 2001 *
MIPS CORUM Emerin architectural complex: Emerin architectural complex complex (ACTB-EMD-LMNA-LMNB1-NMI-SPTAN1) Holaska et al., Biochemistry 2007
MIPS CORUM Emerin complex 24: Emerin complex 24 complex (BANF2-C1QBP-EMD-HIST1H1A-HIST1H3B-HIST1H3C-HIST1H3A-HIST1H3F-HIST1H3G-HIST1H3D-HIST1H3E-HIST1H3J-HIST1H3H-HIST1H3I-HNRNPU-LMNA-LMNB1-MCM2-MCM4-MCM6-NMI-RB1-RBL2-SAP130) Holaska et al., Biochemistry 2007
IRef Corum Interaction: Complex of 73 proteins (association, ion exchange chromatography) Holaska et al., Biochemistry 2007
IRef Corum Interaction: Complex of 19 proteins (association, molecular sieving) Holaska et al., Biochemistry 2007
IRef Dip Interaction: LMNA — LMNB1 (physical association, anti tag coimmunoprecipitation) Liu et al., Nature 2011 *
IRef Dip Interaction: Complex of LMNA-PRKDC-LMNB1 (anti tag coimmunoprecipitation) Liu et al., Nature 2011 *
IRef Dip Interaction: Complex of LMNA-EMD-LMNB2-PRKDC-LMNB1 (anti tag coimmunoprecipitation) Liu et al., Nature 2011 *
Gene Ontology Complexes intermediate filament: intermediate filament complex (KRT39-KRT38-KRTAP4-2-KRT31-NME1-NME2-KRT32-KRT35-KRT34-KRT37-KRT36-KRT222-KRTAP4-6-KRTAP3-1-MICAL1-KRTAP1-1-KRT28-KRTAP1-3-KRTAP1-4-KRTAP1-5-KRT23-KRT20-KRT26-KRT27-KRT24-KRT25-LMNTD1-KRTAP21-3-KRTAP27-1-KRTAP20-2-KRTAP20-3-KRTAP20-1-KRTAP20-4-KRTAP10-8-KRTAP6-2-KRTAP10-5-KRTAP10-4-KRTAP10-3-KRTAP10-2-KRTAP10-1-VIM-KRTAP23-1-KRTAP25-1-SYNM-DES-SYNC-PRPH-FLG-KRTAP4-9-KRTAP9-9-KRTAP7-1-KRTAP9-1-KRTAP9-2-KRTAP9-3-KRTAP9-4-KRTAP4-4-KRTAP9-6-KRTAP9-7-JUP-KRT40-KRTAP10-12-DSP-KRTAP10-10-KRTAP12-1-GJA1-KRTAP12-3-KRTAP12-2-KRTAP12-4-KRTAP24-1-KRT17-KRT16-KRT15-KRT14-KRT12-KRT10-INA-KRT19-KRT18-KRT75-KRT74-KRT77-KRT76-KRT71-KRT73-KRT72-KRT79-KRT78-KRT3-KRT2-KRT1-KRT7-KRT4-KRT9-KRT8-NES-KRTAP5-10-KRT80-KRT81-KRT82-KRT83-KRT84-KRT85-KRT86-KRTAP19-2-KRTAP19-3-KRTAP19-1-KRT6B-KRT6C-KRTAP19-4-KRT6A-KRTAP19-6-KRTAP19-8-KRTAP19-7-KRTAP5-4-LMNB2-KRTAP5-6-KRTAP5-7-KRTAP5-1-KRTAP5-2-KRTAP5-3-KRTAP2-3-KRTAP2-1-KRTAP19-5-KRTAP5-9-KRTAP15-1-LMNB1-KRTAP4-16P-KRTAP2-4-KRTAP16-1-KRTAP21-2-KRTAP21-1-KRTAP11-1-KRTAP22-1-KRTAP22-2-KRTAP5-5-EIF6-KRTAP4-5-KRTAP8-1-KRTAP29-1-NCKIPSD-KRT87P-NEFL-KRT33A-KRTAP6-3-NEFH-KRTAP6-1-CLIP1-KRTAP17-1-GFAP-KRTAP4-8-KRTAP3-2-BFSP2-MNS1-BFSP1-KRTAP13-4-KRTAP13-1-KRTAP13-2-KRTAP13-3-KRTAP4-11-LMNA-KRTAP4-12-KRTAP26-1-KRTAP3-3-NEFM-KRT33B-SLC1A4-KRTAP4-3) de Bernard et al., EMBO J 2000, Hofmann et al., J Cell Sci 2000, Suzuki et al., J Biol Chem 2002, Collin et al., Differentiation 1992, Collin et al., Exp Cell Res 1992, Bilbe et al., EMBO J 1992, Yang et al., Circ Res 2006, Langbein et al., J Biol Chem 2010, Glass et al., J Cell Biol 1985, Leube et al., J Cell Biol 1988, Zhou et al., J Biol Chem 1988, McKinley-Grant et al., Proc Natl Acad Sci U S A 1989, Moll et al., Differentiation 1993, Ku et al., J Biol Chem 1997, Irvine et al., Nat Genet 1997, Winter et al., J Biol Chem 1997, Hess et al., Exp Eye Res 1998, Muñoz-Mármol et al., Proc Natl Acad Sci U S A 1998, Yaworsky et al., Dev Biol 1999
IRef Hprd Interaction: LMNA — LMNB1 (in vitro) Ostlund et al., J Cell Sci 2001 *
IRef Hprd Interaction: LMNA — LMNB1 (two hybrid) Ostlund et al., J Cell Sci 2001 *
IRef Intact Interaction: LMNA — LMNB1 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
IRef Intact Interaction: Complex of 39 proteins (association, anti tag coimmunoprecipitation) Liu et al., Nature 2012
IRef Intact Interaction: Complex of 13 proteins (association, anti tag coimmunoprecipitation) Pan et al., EMBO J 2013
IRef Intact Interaction: Complex of 79 proteins (association, anti bait coimmunoprecipitation) Huang et al., Cancer Cell 2013
IRef Ophid Interaction: LMNA — LMNB1 (aggregation, confirmational text mining) Ostlund et al., J Cell Sci 2001 *
IRef Ophid Interaction: LMNA — LMNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005