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Gene interactions and pathways from curated databases and text-mining
Dev Biol 1999, PMID: 9917366

Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene.

Yaworsky, P J; Kappen, C

Using transgenic embryos, we have identified two distinct CNS progenitor cell-specific enhancers, each requiring the cooperation of at least two independent regulatory sites, within the second intron of the rat nestin gene. One enhancer is active throughout the developing CNS, while the other is specifically active in the ventral midbrain. These experiments demonstrate that neural progenitor cells in the midbrain constitute a unique subpopulation based upon their ability to activate the midbrain regulatory element. Our finding of differential enhancer activity from a gene encoding a structural protein reveals a previously unrecognized diversity in neural progenitor cell populations.

Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • Gene Ontology Complexes intermediate filament: intermediate filament complex (KRT39-KRT38-KRTAP4-2-KRT31-NME1-NME2-KRT32-KRT35-KRT34-KRT37-KRT36-KRT222-KRTAP4-6-KRTAP3-1-MICAL1-KRTAP1-1-KRT28-KRTAP1-3-KRTAP1-4-KRTAP1-5-KRT23-KRT20-KRT26-KRT27-KRT24-KRT25-LMNTD1-KRTAP21-3-KRTAP27-1-KRTAP20-2-KRTAP20-3-KRTAP20-1-KRTAP20-4-KRTAP10-8-KRTAP6-2-KRTAP10-5-KRTAP10-4-KRTAP10-3-KRTAP10-2-KRTAP10-1-VIM-KRTAP23-1-KRTAP25-1-SYNM-DES-SYNC-PRPH-FLG-KRTAP4-9-KRTAP9-9-KRTAP7-1-KRTAP9-1-KRTAP9-2-KRTAP9-3-KRTAP9-4-KRTAP4-4-KRTAP9-6-KRTAP9-7-JUP-KRT40-KRTAP10-12-DSP-KRTAP10-10-KRTAP12-1-GJA1-KRTAP12-3-KRTAP12-2-KRTAP12-4-KRTAP24-1-KRT17-KRT16-KRT15-KRT14-KRT12-KRT10-INA-KRT19-KRT18-KRT75-KRT74-KRT77-KRT76-KRT71-KRT73-KRT72-KRT79-KRT78-KRT3-KRT2-KRT1-KRT7-KRT4-KRT9-KRT8-NES-KRTAP5-10-KRT80-KRT81-KRT82-KRT83-KRT84-KRT85-KRT86-KRTAP19-2-KRTAP19-3-KRTAP19-1-KRT6B-KRT6C-KRTAP19-4-KRT6A-KRTAP19-6-KRTAP19-8-KRTAP19-7-KRTAP5-4-LMNB2-KRTAP5-6-KRTAP5-7-KRTAP5-1-KRTAP5-2-KRTAP5-3-KRTAP2-3-KRTAP2-1-KRTAP19-5-KRTAP5-9-KRTAP15-1-LMNB1-KRTAP4-16P-KRTAP2-4-KRTAP16-1-KRTAP21-2-KRTAP21-1-KRTAP11-1-KRTAP22-1-KRTAP22-2-KRTAP5-5-EIF6-KRTAP4-5-KRTAP8-1-KRTAP29-1-NCKIPSD-KRT87P-NEFL-KRT33A-KRTAP6-3-NEFH-KRTAP6-1-CLIP1-KRTAP17-1-GFAP-KRTAP4-8-KRTAP3-2-BFSP2-MNS1-BFSP1-KRTAP13-4-KRTAP13-1-KRTAP13-2-KRTAP13-3-KRTAP4-11-LMNA-KRTAP4-12-KRTAP26-1-KRTAP3-3-NEFM-KRT33B-SLC1A4-KRTAP4-3)
In total, 13695 gene pairs are associated to this article in curated databases