◀ Back to MAPK6
IL3 — MAPK6
Text-mined interactions from Literome
Deng et al., Proc Natl Acad Sci U S A 2000
:
p44MAPK/extracellular signal regulated kinase 1 ( ERK1 ) and p42
MAPK/ERK2 are
activated by
IL-3 , colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo
McDermott et al., J Biol Chem 2002
:
Ras participates in the
activation of p38
MAPK by
interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
Grill et al., Blood 2002
(MAP Kinase Signaling System) :
Inhibition of increases in PI-3K activity by Ly294002 had no effect on the
IL-3 induced activation of p38
MAPK
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by tumor necrosis factor,
interleukin-1alpha , or gamma-interferon
Jee et al., J Invest Dermatol 2002
(Carcinoma, Basal Cell...) :
Next,
interleukin-6 stimulation elicited extracellular signal regulated kinase activation in basal cell carcinoma cells, and the
mitogen activated protein kinase inhibitor, PD98059, could
affect this response without affecting the interleukin-6-medi ated Mcl-1 upregulation
Wong et al., Am J Respir Cell Mol Biol 2003
:
IL-3 , IL-5, and GM-CSF could
enhance p38
MAPK and NF-kappaB activity and induce ICAM-1, CD11b, and CD18 expressions on eosinophils
Mason et al., Infect Immun 2004
:
TRAF6 dependent
mitogen activated protein kinase activation differentially
regulates the production of
interleukin-12 by macrophages in response to Toxoplasma gondii
Nonami et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
Spred-1 negatively regulates
interleukin-3 mediated
ERK/mitogen activated protein ( MAP ) kinase activation in hematopoietic cells
Ip et al., Immunopharmacol Immunotoxicol 2005
:
IL-3 , IL-5, and GM-CSF could
augment the phosphorylation of p38
MAPK and nucleus translocation of NF-kappaB in eosinophils
Hamdi et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
As a functional
consequence of this PLD2 dependent
MAPK activation,
interleukin-2 production evoked by PMA/ionomycin stimulation or CD3/CD28 engagement was enhanced in the two T-cell lines overexpressing PLD2
Munitz et al., Gastroenterology 2010
(Colitis...) :
In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6,
interleukin-1beta , and tumor necrosis factor alpha ) and
activation of
MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Glossop et al., J Tissue Eng Regen Med 2010
:
In a previous gene expression study, we reported a potentially important
role for mitogen activated protein kinase kinase kinase 8 ( MAP3K8 ) and
interleukin-1ß ( IL-1B ) in
MAPK signalling in MSCs exposed to fluid shear stress
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
Pomegranate extract inhibits the
interleukin-1ß induced
activation of MKK-3,
p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Dauphinee et al., Am J Physiol Heart Circ Physiol 2011
:
We find that Ga ( i/o ) -mediated activation of the
MAPK is
independent of the canonical MyD88,
interleukin-1 receptor associated kinase, and tumor necrosis factor receptor associated factor 6 signaling cascade in LPS stimulated cells
Tormos et al., Hepatology 2013
(Chronic Disease...) :
p38a mitogen activated protein kinases (
MAPK ) may be essential in the up-regulation of proinflammatory cytokines and can be
activated by transforming growth factor ß, tumor necrosis factor-a,
interleukin-1ß , and oxidative stress
Terada et al., J Biol Chem 1995
:
Induction of the dominant negative Ras ( S17N ) effectively inhibited the
IL-3 induced activation of c-Raf-1 and
mitogen activated protein kinase ( MAPK )
O'Farrell et al., Blood 1996
:
Interestingly,
IL-3 plus SCF synergistically
activate MAPK