◀ Back to STX1A

STX1A — STXBP1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Effects of Botulinum toxin: STXIA/STXBP1 complex (STX1A-STXBP1) → SNAP25 (SNAP25) (modification, inhibits) Gladycheva et al., J Physiol 2004, Liu et al., J Biol Chem 2004, Toonen et al., J Neurochem 2005
  Evidence: assay
• NCI Pathway Database Effects of Botulinum toxin: STXIA/STXBP1 complex (STX1A-STXBP1) → STX1A (STX1A) (modification, inhibits) Gladycheva et al., J Physiol 2004, Liu et al., J Biol Chem 2004, Toonen et al., J Neurochem 2005
  Evidence: assay
• NCI Pathway Database Effects of Botulinum toxin: STXIA/STXBP1 complex (STX1A-STXBP1) → RAB3GAP2/RIMS1/UNC13B complex (RAB3GAP2-RIMS1-UNC13B) (modification, inhibits)
  Gladycheva et al., J Physiol 2004, Liu et al., J Biol Chem 2004, Toonen et al., J Neurochem 2005
  Evidence: assay
• NCI Pathway Database Effects of Botulinum toxin: STX1A (STX1A) → STXIA/STXBP1 complex (STX1A-STXBP1) (modification, collaborate)
  
• NCI Pathway Database Effects of Botulinum toxin: STX1A (STX1A) → STXBP1 (STXBP1) (modification, collaborate)
• NCI Pathway Database Effects of Botulinum toxin: STXIA/STXBP1 complex (STX1A-STXBP1) → STXBP1 (STXBP1) (modification, collaborate)
• NCI Pathway Database Effects of Botulinum toxin: SNAP25 fragment 1 (SNAP25) → STXIA/STXBP1 complex (STX1A-STXBP1) (modification, collaborate)
  Gladycheva et al., J Physiol 2004, Liu et al., J Biol Chem 2004, Toonen et al., J Neurochem 2005
  Evidence: assay
• NCI Pathway Database Effects of Botulinum toxin: VAMP2 (VAMP2) → STXIA/STXBP1 complex (STX1A-STXBP1) (modification, collaborate)
  Gladycheva et al., J Physiol 2004, Liu et al., J Biol Chem 2004, Toonen et al., J Neurochem 2005
  Evidence: assay
• Reactome Reaction: STXBP1 → STX1A (direct_complex) Augustin et al., Nature 1999, Toonen et al., J Neurochem 2005, Quick et al., Handb Exp Pharmacol 2006, Dulubova et al., Proc Natl Acad Sci U S A 2007, Khvotchev et al., J Neurosci 2007, Binda et al., Mol Pharmacol 2008, Riento et al., J Cell Sci 1998
• Reactome Reaction: STXBP1 → STX1A (reaction) Augustin et al., Nature 1999, Deken et al., Nat Neurosci 2000, Barclay et al., J Biol Chem 2003, Gasnier et al., Pflugers Arch 2004, Toonen et al., J Neurochem 2005, Quick et al., Handb Exp Pharmacol 2006, Dulubova et al., Proc Natl Acad Sci U S A 2007, Martens et al., Science 2007, Stein et al., Nature structural & molecular biology 2007, Khvotchev et al., J Neurosci 2007, Binda et al., Mol Pharmacol 2008, Koch et al., Curr Opin Neurobiol 2009, Riento et al., J Cell Sci 1998
• WikiPathways Synaptic Vesicle Pathway: STXBP1 → STX1B/STX2/STX1A/STX3 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STX1A — STXBP1 (direct interaction, pull down) Barclay et al., J Biol Chem 2003
• IRef Biogrid Interaction: STX1A — STXBP1 (physical association, affinity chromatography technology) Bhaskar et al., Neurochem Int 2004*
• IRef Biogrid Interaction: STX1A — STXBP1 (physical association, affinity chromatography technology) Dulubova et al., EMBO J 1999*
• IRef Biogrid Interaction: STX1A — STXBP1 (physical association, affinity chromatography technology) McMahon et al., Cell 1995
• IRef Biogrid Interaction: STX1A — STXBP1 (direct interaction, pull down) Pérez-Brangulí et al., Mol Cell Neurosci 2002*
• Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3) Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
• IRef Hprd Interaction: STX1A — STXBP1 (in vitro) Reed et al., Blood 1999*, Dulubova et al., EMBO J 1999*, Misura et al., Nature 2000*, Ciufo et al., Mol Biol Cell 2005*, Connell et al., EMBO Rep 2007*, Pevsner et al., Proc Natl Acad Sci U S A 1994*, Tellam et al., J Biol Chem 1997*
• IRef Hprd Interaction: STX1A — STXBP1 (in vivo) Reed et al., Blood 1999*, Dulubova et al., EMBO J 1999*, Misura et al., Nature 2000*, Ciufo et al., Mol Biol Cell 2005*, Connell et al., EMBO Rep 2007*, Pevsner et al., Proc Natl Acad Sci U S A 1994*, Tellam et al., J Biol Chem 1997*
• IRef Hprd Interaction: Complex of STX1A-STXBP1-SNAP25-SNAP25-STXBP1-STX1A-STXBP1-SNAP25-STX1A (in vivo) Connell et al., EMBO Rep 2007*
• IRef Ophid Interaction: STX1A — STXBP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: STX1A — STXBP1 (aggregation, confirmational text mining) Tellam et al., J Biol Chem 1997*

Text-mined interactions from Literome

Rickman et al., J Biol Chem 2007 : Syntaxin 1a , a core component of the exocytic SNARE complex in neurons and neuroendocrine cells, is regulated directly by munc18-1 , its cognate Sec1p/munc18 (SM) protein
Han et al., Mol Biol Cell 2009 : To precisely define the contributions of each binding mode, we have engineered Munc18-1/-2 double knockdown neurosecretory cells and show that not only syntaxin-1A and -1B but also syntaxin-2 and -3 are significantly reduced as a result of Munc18-1 and -2 knockdown
Pevsner et al., Proc Natl Acad Sci U S A 1994 : In the presence of syntaxin 1a , a plasma membrane protein implicated in synaptic vesicle docking, n-Sec1 becomes membrane associated
Naren et al., Nature 1997 (Cystic Fibrosis) : The physical and functional interactions between syntaxin 1A and CFTR are blocked by a syntaxin binding protein of the Munc18 protein family ( also called n-Secl )