◀ Back to FADD

FADD — RIPK1

Pathways - manually collected, often from reviews:

• BioCarta nf-kb signaling pathway: TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta nf-kb signaling pathway: TNF-alpha (TNF) → TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: TNF-alpha (TNF) → TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: TNF R/FADD/TRADD/RIP/TRAF6 complex (TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) → TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12) → APO-3L (TNFSF12) (modification, collaborate)
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12) → DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10 complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: APO-3L (TNFSF12) → DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10 complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10) (modification, collaborate)
  
• BioCarta tnfr1 signaling pathway: TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD) → FADD (modification, activates)
• BioCarta tnfr1 signaling pathway: TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD) → FADD/Caspase 8 complex (CASP8-FADD) (modification, activates)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12) → Caspase 3 (CASP3) (modification, activates)
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12) → Caspase 3 (active) (CASP3) (modification, activates)
  
• BioCarta ceramide signaling pathway: FADD/Caspase 8 complex (CASP8-FADD) → TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR3/TRADD/FADD/TRAF2/RIP/Caspase 8/Caspase 10/APO-3L complex (TNFRSF25-TRADD-FADD-TRAF2-RIPK1-CASP8-CASP10-TNFSF12) → MAP3K14 (modification, activates)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TRAF1 → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: RAIDD (CRADD) → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: SODD (BAG4) → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → cIAP2 (BIRC3) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → ASK1 (MAP3K5) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TRADD (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TRAF2 (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → Caspase 2 (CASP2) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → FADD (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → RIP (RIPK1) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: FADD → RIP (RIPK1) (modification, collaborate)
• KEGG RIG-I-like receptor signaling pathway: TRADD → Complex of FADD-RIPK1 (protein-protein, binding/association)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, activates)
  Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: RAIDD (CRADD) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FADD (FADD) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FADD (FADD) → RIP (RIPK1) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: ASK1 (MAP3K5) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TRAF1 (TRAF1) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: cIAP2 (BIRC3) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: BAG4 (BAG4) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: Caspase 2 (CASP2) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → TRADD (TRADD) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → RIP (RIPK1) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → TRAF2 (TRAF2) (modification, collaborate)
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
  Evidence: mutant phenotype, reporter gene
• NCI Pathway Database Ceramide signaling pathway: FADD/Caspase 8 complex (CASP8-FADD) → TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF) (modification, collaborate)
  Boldin et al., Cell 1996, Muzio et al., Cell 1996
  Evidence: assay
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → NIK (MAP3K14) (modification, activates) Malinin et al., Nature 1997
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, inhibits)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: RIP (RIPK1) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: RIP (RIPK1) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRADD (TRADD) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10B-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → MEKK1 (MAP3K1) (modification, activates) Hu et al., J Biol Chem 1999
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10A-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → MEKK1 (MAP3K1) (modification, activates) Hu et al., J Biol Chem 1999
  Evidence: genetic interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, inhibits)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAF2 (TRAF2) → TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAF2 (TRAF2) → TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10A-FADD-TRADD-RIPK1-TRAF2-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10A-FADD-TRADD-RIPK1-TRAF2-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Kreuz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Lin et al., Mol Cell Biol 2000, Harper et al., J Biol Chem 2001, Chaudhary et al., Immunity 1997
  Evidence: mutant phenotype, assay, reporter gene
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10B-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → TRAF2 (TRAF2) (modification, collaborate) Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 complex (TNFRSF10B-FADD-TRADD-RIPK1-TRAF2-TNFSF10) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TRAIL signaling pathway: TRAF2 (TRAF2) → TRAIL/TRAILR2/FADD/TRADD/RIP complex (TNFRSF10B-FADD-TRADD-RIPK1-TNFSF10) (modification, collaborate)
  Hu et al., J Biol Chem 1999, Lin et al., Mol Cell Biol 2000
  Evidence: genetic interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF) (modification, activates)
  Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → TRADD (TRADD) (modification, collaborate) Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → RIP (RIPK1) (modification, collaborate) Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD/TRADD/RIP complex (TNFRSF10A-FADD-TRADD-RIPK1-TNFSF10) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: RIP (RIPK1) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Lin et al., Mol Cell Biol 2000, Jin et al., Mol Cell Biol 2006, Chaudhary et al., Immunity 1997
  Evidence: physical interaction
• Reactome Reaction: FADD → RIPK1 (reaction) Wang et al., Proc Natl Acad Sci U S A 2001, Kalai et al., Cell Death Differ 2002, Donepudi et al., Mol Cell 2003, Creagh et al., Immunol Rev 2003, Shikama et al., Eur J Immunol 2003, Micheau et al., Cell 2003, Han et al., J Biol Chem 2004, Kaiser et al., J Immunol 2005, Kawai et al., Nat Immunol 2005, Takahashi et al., J Immunol 2006, Lamkanfi et al., J Cell Biol 2006, Maelfait et al., Biochem Pharmacol 2008, Keller et al., Structure 2009, Oberst et al., J Biol Chem 2010, Tenev et al., Mol Cell 2011, Feoktistova et al., Mol Cell 2011, Estornes et al., Cell Death Differ 2012
• Reactome Reaction: FADD → RIPK1 (indirect_complex) Micheau et al., Cell 2003
• Reactome Reaction: FADD → RIPK1 (direct_complex) Kalai et al., Cell Death Differ 2002, Creagh et al., Immunol Rev 2003, Han et al., J Biol Chem 2004, Kaiser et al., J Immunol 2005, Tenev et al., Mol Cell 2011, Feoktistova et al., Mol Cell 2011, Estornes et al., Cell Death Differ 2012
• WikiPathways RIG-I-like Receptor Signaling: Complex of FADD-RIPK1 → Complex of CASP8-CASP10 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) Young et al., J Biol Chem 2011*
• IRef Biogrid Interaction: FADD — RIPK1 (direct interaction, two hybrid) Chen et al., J Biol Chem 2002*
• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) Puliyappadamba et al., Cell reports 2013
• IRef Biogrid Interaction: FADD — RIPK1 (direct interaction, pull down) Tenev et al., Mol Cell 2011
• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) Legarda-Addison et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) O'Donnell et al., PloS one 2012*
• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) Vanlangenakker et al., Cell Death Differ 2011*
• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) Biton et al., Cell 2011*
• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) Lee et al., Nature communications 2012
• IRef Biogrid Interaction: FADD — RIPK1 (physical association, affinity chromatography technology) Ramakrishnan et al., Mol Cell 2011*
• IRef Dip Interaction: Complex of FADD-CASP8-RIPK1-TNFAIP3 (anti bait coimmunoprecipitation) Oshima et al., Nature 2009*
• IRef Dip Interaction: Complex of FADD-FADD-RIPK1-RIPK1 (anti tag coimmunoprecipitation) Oshima et al., Nature 2009*
• Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3) Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
• Gene Ontology Complexes ripoptosome: ripoptosome complex (RIPK1-TICAM1-RIPK3-CASP10-FADD) Feoktistova et al., Mol Cell 2011
• Gene Ontology Complexes death-inducing signaling complex: death-inducing signaling complex complex (RIPK1-TRADD-FADD) Holler et al., Nat Immunol 2000, Galluzzi et al., Cell Death Differ 2008*, Tao et al., Blood 2011
• IRef Hprd Interaction: FADD — RIPK1 (in vivo) Kim et al., Oncogene 2000*, Cho et al., Cell 2009*
• IRef Intact Interaction: Complex of FADD-RIPK1-RIPK3-CASP8 (physical association, anti bait coimmunoprecipitation) He et al., Cell 2009*
• IRef Intact Interaction: Complex of FADD-RIPK1-IKBKG (association, anti bait coimmunoprecipitation) Biton et al., Cell 2011*
• IRef Intact Interaction: Complex of CASP8-RIPK1-TNFRSF10A-TNFRSF10B-FADD-CFLAR (association, anti bait coimmunoprecipitation) Rébé et al., Blood 2007
• IRef Intact Interaction: Complex of CASP8-FADD-RIPK1-BIRC2 (association, anti bait coimmunoprecipitation) Feoktistova et al., Cell cycle (Georgetown, Tex.) 2012*
• IRef Intact Interaction: Complex of TRAF2-RIPK1-TRADD-FADD-CASP8-CFLAR (association, anti bait coimmunoprecipitation) Rébé et al., Blood 2007
• IRef Intact Interaction: Complex of 17 proteins (association, anti bait coimmunoprecipitation) Rébé et al., Blood 2007
• IRef Intact Interaction: Complex of TRAF2-TRAF1-TRADD-FADD-CASP8-CFLAR-BIRC2-RIPK1 (association, anti bait coimmunoprecipitation) Micheau et al., Cell 2003
• IRef Intact Interaction: Complex of CASP8-CASP10-CFLAR-TRADD-TRAF2-RIPK1-FADD (association, anti bait coimmunoprecipitation) Micheau et al., Cell 2003
• IRef Intact Interaction: FADD — RIPK1 (physical association, anti tag coimmunoprecipitation) Cho et al., Cell 2009*
• IRef Intact Interaction: FADD — RIPK1 (physical association, anti bait coimmunoprecipitation) Biton et al., Cell 2011*
• IRef Intact Interaction: Complex of FADD-RIPK3-RIPK1 (association, anti bait coimmunoprecipitation) Cho et al., Cell 2009*
• IRef Intact Interaction: Complex of 31 proteins (association, anti bait coimmunoprecipitation) Löder et al., Leukemia 2012*
• IRef Ophid Interaction: FADD — RIPK1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: FADD — RIPK1 (aggregation, confirmational text mining) Kim et al., Oncogene 2000*

Text-mined interactions from Literome

Northington et al., J Cereb Blood Flow Metab 2011 (Encephalitis...) : Hypoxia-ischemia enforced RIP1-RIP3 complex formation and inhibited RIP3-FADD ( Fas associated protein with death domain ) interaction, and these effects were blocked by necrostatin
Löder et al., Leukemia 2012 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Similarly, inhibition of RIP1 kinase activity by Necrostatin-1 or blockage of TNFa by Enbrel inhibits IAP inhibitor- and AraC triggered interaction of RIP1, FADD and caspase-8 and apoptosis
Abhari et al., Oncogene 2013 : RIP1 is required for the formation of a RIP1/FADD/caspase-8 complex that drives caspase-8 activation, cleavage of Bid into tBid, mitochondrial outer membrane permeabilization, full activation of caspase-3 and caspase dependent apoptosis