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IL17A — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL17A → IL6 (increases) Kim et al., Arthritis Res Ther 2005*
  Evidence: IL-15, monocyte chemoattractant protein-1 and IL-6 upregulated IL-17 production
• NCI Pathway Database IL27-mediated signaling events: IL6 (IL6) → IL17 (IL17A) (transcription, activates) Stumhofer et al., Nat Immunol 2006*, Batten et al., Nat Immunol 2006*
  Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Tartour et al., Cancer Res 1999 (Melanoma...) : We showed that in vitro, IL-17 increases IL-6 and IL-8 secretion by cervical carcinoma cell lines at both protein and mRNA levels
Van bezooijen et al., J Bone Miner Res 1999 (Bone Resorption) : In addition, IL-17 increased TNF-alpha induced IL-1alpha, IL-1beta, and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells
Kehlen et al., J Neuroimmunol 1999 (Glioblastoma) : Furthermore, IL-17 stimulated the secretion of IL-6 and IL-8 in glial cells, and IL-17 and IL-1beta in combination showed a superadditive effect
Schwandner et al., J Exp Med 2000 : Consequently, IL-17 induced IL-6 and intercellular adhesion molecule 1 expression in the TRAF6-deficient cells was abolished
Molet et al., J Allergy Clin Immunol 2001 (Asthma) : IL-17 did enhance the production of pro-fibrotic cytokines ( IL-6 and IL-11 ) by fibroblasts, and this was inhibited by dexamethasone
Trajkovic et al., J Neuroimmunol 2001 (Astrocytoma) : While IL-17 stimulated both IL-1beta and IL-6 production in astrocytes, only IL-1 was partly responsible for IL-17 induced NO release
Katz et al., Arthritis Rheum 2001 (Inflammation) : ELISA measured secretion of IL-6 and IL-8 increased by 6.7 and 5.8 times, respectively, with IL-17 , compared with 52 and 269 times with TNFalpha stimulation and 1,356 and 1,084 times with IL-1beta stimulation
Jovcić et al., Growth Factors 2001 : In normal mice IL-17 increased CFU-GM and BFU-E and reduced CFU-E derived colonies numbers and augmented release of IL-6 and EPO ... After irradiation, IL-17 increased the release of IL-1alpha, IL-6 and EPO
Kawaguchi et al., J Allergy Clin Immunol 2001 (MAP Kinase Signaling System) : We showed first that IL-17 induced time dependent expression of IL-6 and IL-8 but not of the chemokines eotaxin and RANTES ... A selective MAP kinase kinase inhibitor, PD98059, inhibited IL-17 induced IL-6 and IL-8
Shimada et al., J Immunol 2002 : IL-6 secretion was rapidly induced by IL-17 , IL-1beta, and TNF-alpha ... Furthermore, IL-17 , IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly reduced IL-17-, IL-1beta-, or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Hata et al., Am J Physiol Gastrointest Liver Physiol 2002 (Inflammatory Bowel Diseases) : We investigated the effects of interleukin (IL)-17 on IL-6 and chemokine [ IL-8 and monocyte chemoattractant protein (MCP)-1 ] secretion in colonic SEMFs ... IL-6 , IL-8, and MCP-1 secretions were rapidly induced by IL-17 ... MAPK inhibitors ( SB-203580, PD-98059, and U-0126 ) significantly reduced the IL-17 induced IL-6 and chemokine secretion ... The combination of either IL-17 + IL-1beta or IL-17 + tumor necrosis factor (TNF)-alpha enhanced cytokine secretion ; in particular, the effects of IL-17 + TNF-alpha on IL-6 secretion were much stronger than the other responses ... In conclusion, human SEMFs secreted IL-6 , IL-8, and MCP-1 in response to IL-17
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2002 : Interleukin (IL)-17 enhances prostaglandin F ( 2 alpha ) -stimulated IL-6 synthesis in osteoblasts ... In the present study, we investigated the effect of IL-17 on the IL-6 synthesis stimulated by PGF ( 2alpha ) in MC3T3-E1 cells ... These results strongly suggest that IL-17 enhances the IL-6 synthesis stimulated by PGF ( 2alpha ) as well as ET-1 in osteoblasts, and that the effect is exerted at a point downstream from p44/p42 MAP kinase
Andoh et al., J Immunol 2002 : IL-17 enhances the TNF-alpha induced IL-6 and IL-8 secretion in human colonic subepithelial myofibroblasts
Andoh et al., Biochim Biophys Acta 2002 : In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha induced IL-6 secretion through the induction of IL-6 mRNA stabilization
Andoh et al., Int J Mol Med 2002 (Inflammatory Bowel Diseases) : Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts ... In this study, we evaluated the effects of IL-4 and/or IL-17 on IL-6 secretion in human colonic myofibroblasts ... IL-6 secretion was rapidly induced by either IL-4 or IL-17 ... IL-17 induced IL-6 mRNA expression within 1 h after stimulation, and reached a maximum at 3 h. IL-6 mRNA induction by IL-4 occurred more rapidly
Maertzdorf et al., J Immunol 2002 (Keratitis, Herpetic) : IL-17 exhibited a strong synergistic effect with TNF-alpha on the induction of IL-6 and IL-8 secretion by cultured HCF
Chevrel et al., J Neuroimmunol 2003 (Myositis) : Both IL-17 and IL-1 beta induced IL-6 production by normal myoblasts and muscle samples
Steiner et al., Prostate 2003 (Carcinoma...) : The effect of IL-17 on IL-6 , IL-8, TGF-beta1, and fibroblast growth factor ( FGF-2 ) mRNA expression and/or release of SC was analyzed using real-time PCR and/or ELISA
Dong et al., Chin Med J (Engl) 2003 (Lupus Nephritis) : IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients ... The increase in IgG, anti-dsDNA and IL-6 protein levels induced by IL-17 was dose dependent and could be completely blocked by IL-17 monoclonal antibody mIgG ( 28 ) and partially blocked by dexamethasone
Ruddy et al., J Biol Chem 2004 : Because C/EBP family members are known to control IL-6, we examined whether enhanced C/EBPdelta expression is involved in the cooperative up-regulation of IL-6 by IL-17 and TNFalpha
Tokuda et al., J Cell Biochem 2004 : Interleukin (IL)-17 enhances tumor necrosis factor-alpha stimulated IL-6 synthesis via p38 mitogen activated protein kinase in osteoblasts ... It has been reported that IL-17 enhances TNF-alpha stimulated IL-6 synthesis in osteoblast-like MC3T3-E1 cells ... SB203580 and PD169316, specific inhibitors of p38 MAP kinase, significantly reduced the enhancement by IL-17 of TNF-alpha stimulated IL-6 synthesis ... Taken together, our results strongly suggest that IL-17 enhances TNF-alpha stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts
Hwang et al., Arthritis Res Ther 2004 (Arthritis, Rheumatoid) : IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt dependent pathways ... IL-17 mediated induction of IL-6 and IL-8 was transduced via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB, while CD40 ligation and p38 MAPK ( mitogen activated protein kinase ) are not likely to partake in the process
Henness et al., J Allergy Clin Immunol 2004 : IL-17A augments TNF-alpha induced IL-6 expression in airway smooth muscle by enhancing mRNA stability ... However, IL-17A ( 10 ng/mL ) significantly augmented TNF-alpha induced IL-6 secretion 12-fold ( TNF-alpha, 2.3 +/- 0.4 ng/mL ; IL-17A and TNF-alpha, 27.5 +/- 4.8 ng/mL ; P < .05 ) while having no effect on IL-1beta induced IL-6
Takahashi et al., J Clin Periodontol 2005 (Periodontitis) : These biological functions are relevant to the aetiopathogenesis of periodontitis, and thus we sought to investigate whether IL-17 is produced in periodontal lesions and to assess the relationship of gene expression between IL-17 and other cytokines, and to determine the effect of IL-17 on IL-6 production in human gingival fibroblasts (HGF)
de Haij et al., J Am Soc Nephrol 2005 : IL-6 production induced by IL-1, TNF-alpha, and IL-17 was specifically inhibited by the c-jun NH ( 2 ) -terminal kinase ( JNK ) inhibitor SP600125, but not by a selective inhibitor of p38 MAPK, and was moderately increased when the ERK1/2 pathway was inhibited
van den Berg et al., Am J Respir Cell Mol Biol 2005 (Asthma...) : We show here for both cell types that IL-17 was a weak stimulus of IL-8 and IL-6 production, but markedly enhanced IL-8 and IL-6 responses to another stimulus, such as tumor necrosis factor-alpha ... In conclusion, IL-17 particularly affects post-transcriptional regulation of IL-8 and IL-6 expression leading to enhanced IL-8 and IL-6 responses to secondary stimuli, and is only a weak proinflammatory stimulus by itself
Yoshida et al., J Rheumatol 2005 : In addition, MTX significantly inhibited the enhancement by IL-17 of TNF-alpha stimulated IL-6 synthesis
Schnyder et al., Cytokine 2005 : Neutralization of the human IL-17 receptor (IL-17R) by M202 antibody competitively reverses the IL-17 induced IL-6 upregulation
Ning et al., Am J Physiol Lung Cell Mol Physiol 2005 (MAP Kinase Signaling System) : Carbon monoxide inhibits IL-17 induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells ... Herein, we examine the production of cytokine IL-6 induced by IL-17 and the effect of CO on IL-17 induced IL-6 production in human pulmonary epithelial cell A549 ... We first show that IL-17 can induce A549 cells to release IL-6 and that CO can markedly inhibit IL-17 induced IL-6 production ... Furthermore, in the presence of U0126 and PD-98059, selective inhibitors of MEK1/2, IL-17 induced IL-6 production was significantly attenuated
Persson et al., Biochem Biophys Res Commun 2005 : The IL-6 protein release from calvarial osteoblasts was also stimulated by the osteoclastogenic, proinflammatory cytokines IL-11, LIF, OSM, IL-17 , TGF-beta, and TNF-alpha
Li et al., Eur J Cardiothorac Surg 2006 : IL-17R-Ig activity was assessed by inhibition of IL-17 induced IL-6 release in HeLa cells preincubated with the vector
Jovcić et al., Physiol Res 2007 : IL-17 increased the release of IL-6 both in vitro and in vivo, but showed tendency to suppress the constitutive secretion of IL-10 by spleen cells
Beklen et al., J Dent Res 2007 (Periodontitis) : IL-17 was less potent as a direct MMP inducer than IL-1beta and TNF-alpha, but it induced IL-1beta and TNF-alpha production from macrophages, and IL-6 and IL-8 from gingival fibroblasts
Chang et al., Cell Res 2007 (Inflammation) : IL-17A/F regulation of IL-6 and KC expression is dependent on IL-17RA and TRAF6
Korn et al., Nature 2007 (Encephalomyelitis, Autoimmune, Experimental...) : Whereas TGF-beta induces Foxp3 and generates T ( reg ) cells, IL-6 inhibits the generation of T ( reg ) cells and induces the production of IL-17 , suggesting a reciprocal developmental pathway for T ( H ) 17 and T ( reg ) cells
Kryczek et al., J Immunol 2007 : Endogenous and exogenous IL-1 dramatically contribute to IL-17 ( + ) T cell differentiation mediated by TGFbeta and IL-6
Peng et al., Invest Ophthalmol Vis Sci 2007 (Autoimmune Diseases...) : In addition, IL-23 promoted the expansion of antigen-specific and non-antigen-specific IL-17 ( + ) T cells, whereas TGF-beta and IL-6 acted only on non-antigen-specific IL-17 ( + ) T cells
Yagi et al., J Gastroenterol 2007 (Colitis) : IL-17A and IL-17F significantly enhanced IL-6 , IL-8, LIF, MMP-1, and MMP-3 secretion ... Both IL-17A and IL-17F augmented IL-1beta induced secretion of IL-6 , IL-8, LIF, MMP-1, and MMP-3
Evans et al., Proc Natl Acad Sci U S A 2007 : IL-6 and IL-21 were unable to induce IL-17 expression in either naïve or effector T cells, and TGF-beta actually inhibited IL-17 expression
Zrioual et al., J Immunol 2008 (Arthritis, Rheumatoid) : Using both posttranslational inhibitions by silencing interfering RNA and extracellular blockade by specific inhibitors, we showed that both IL-17RA and IL-17RC are implicated in IL-17A induced IL-6 secretion, whereas in the presence of TNF-alpha, the inhibition of both receptors was needed to down-regulate IL-17A induced IL-6 and CCL-20 secretion ... Thus, IL-17A induced IL-6 , IL-8, and CCL20 secretion was dependent on both IL-17RA and IL-17RC, which are overexpressed in RA patients
Cheung et al., J Immunol 2008 (Inflammation) : IL-17A , IL-17F, and IL-23 could induce the release of chemokines GRO-alpha/CXCL1, IL-8/CXCL8, and MIP-1beta/CCL4 from eosinophils, while IL-17F and IL-23 could also increase the production of proinflammatory cytokines IL-1beta and IL-6
Graber et al., J Neuroimmunol 2008 (Multiple Sclerosis...) : We conclude that IL-17 and IL-6 production from PBMC in TM and early MS are increased and induce astrocyte IL-6 production through IL-6
Liu et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental...) : The results apply to initial generation of the IL-17 phenotype because naive CD62L ( high ) Daf1 ( -/- ) T cells produce 3-fold more IL-17 in response to TGF-beta and IL-6 , whereas CD62L ( high ) Daf1 ( -/- ) C5aR ( -/- ) C3aR ( -/- ) T cells produce 4-fold less
Ichiyama et al., J Biol Chem 2008 : IL-6 reduced Foxp3 expression, and overexpression of Foxp3 in a T cell line resulted in a strong reduction of IL-17A expression
Manel et al., Nat Immunol 2008 : We show here that TGF-beta, IL-1beta and IL-6 , IL-21 or IL-23 in serum-free conditions were necessary and sufficient to induce IL-17 expression in naive human CD4+ T cells from cord blood
Yang et al., Nature 2008 : Here we confirm that whereas IL-1beta and IL-6 induce IL-17A secretion from human central memory CD4 ( + ) T cells, TGF-beta and IL-21 uniquely promote the differentiation of human naive CD4 ( + ) T cells into T ( H ) 17 cells accompanied by expression of the transcription factor RORC2
Gu et al., Br J Haematol 2008 (Anemia, Aplastic) : The effect of IL-17 on IL-6 and IL-8 production by macrophages was also studied ... IL-17 induced the production of IL-6 and IL-8 by macrophages both from patients with AA and normal controls ... These results suggested that elevated expression of IL-17 and IL-17 induced IL-6 , IL-8 and TNF-alpha may be involved in the mechanisms of AA
Gerosa et al., J Exp Med 2008 : Although IL-23, transforming growth factor beta, and IL-6 contained in the supernatants of activated mono-DCs played a role in the induction of IL-17 by human CD4 ( + ) T cells, IL-1beta, in combination with one or more of those factors, was required for IL-17 production, and its production determined the differential ability of the stimuli used to elicit mono-DCs to produce soluble factors directing IL-17 production
Wang et al., Transpl Immunol 2008 (Disease Models, Animal...) : Further in vitro studies indicated that primary renal tubular epithelial cell (TEC) cultures produced high levels of IL-6 in response to allogeneic lymphocyte or IL-17 stimulation, and neutralization of IL-6 increased CD4 ( + ) CD25 ( + ) Foxp3 ( + ) cells in co-cultures with TEC
Kattah et al., Arthritis Rheum 2008 : IL-6 suppressed the expression of forkhead box P3 and reversed TGFbeta mediated inhibition of T cell proliferation, but did not trigger IL-17 secretion ... IL-1beta and IL-6 independently induced IL-21 secretion, but the presence of IL-21 alone was not sufficient for IL-17 production
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : On the other hand, TNF-alpha and IL-17 did not induce RANKL expression, although TNF-alpha, IL-17 or IL-1beta stimulated cell growth and IL-6 production
Lexberg et al., Eur J Immunol 2008 : For Th17 cells generated in vitro, IL-17 expression itself is dependent on continued TGF-beta/IL-6 or IL-23 signaling and is blocked by interferon-gamma and IL-4 signaling
Eyerich et al., J Allergy Clin Immunol 2009 (Dermatitis, Atopic...) : IL-17 secretion was not enhanced by IL-23, IL-1 beta, or IL-6 but was enhanced by the S aureus derived superantigen staphylococcal enterotoxin B
Lyakh et al., Immunol Rev 2008 : IL-23, IL-6 , transforming growth factor ( TGF-beta1 ), and IL-1beta in supernatants from activated human DCs induce human naive CD4 ( + ) T cells to produce IL-17
Siegemund et al., Int Immunol 2009 (Salmonella Infections) : However, IL-6 was not required for IL-22 or IL-17A production by PEC
Krstić et al., Eur Cytokine Netw 2009 : In addition, the stimulation of IL-6 production by IL-17 in MSC cultures and co-cultures is enhanced by low O2 concentration
Gao et al., Cell cycle (Georgetown, Tex.) 2009 : Unlike IL6, LIF supported expression of Foxp3, the Treg lineage transcription factor, and LIF opposed IL6 by suppressing IL-6 induced IL-17A protein release
Radstake et al., PloS one 2009 (Disease Progression...) : In line with these observation, circulating levels of IL-17 inducing cytokines IL-6 , IL-23 and IL-1alpha were increased in all or subsets of SSc patients
Huber et al., Eur J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental) : The expression of the type 17 master regulator RORgammat is causally linked to Tc17 generation, because its overexpression stimulates production of IL-17 in the presence of IL-6 or IL-21
Wang et al., J Exp Med 2009 (Neoplasms) : IL-17 induces IL-6 production, which in turn activates oncogenic signal transducer and activator of transcription ( Stat ) 3, up-regulating prosurvival and proangiogenic genes
Harada et al., Clin Exp Immunol 2009 (Autoimmune Diseases...) : Moreover, BECs possessed IL-17-receptors and stimulation with IL-17 induced production of IL-6 , IL-1 beta, IL-23p19 and chemokines
Kelchtermans et al., Arthritis Res Ther 2009 (Arthritis, Experimental) : IL-17 and TNF-alpha synergistically induced granulocyte chemotactic protein-2 ( GCP-2 ), IL-6 and receptor activator of NFkappaB ligand ( RANKL ) in MEF
Rovedatti et al., Gut 2009 (Colitis, Ulcerative...) : IL23 and IL1beta plus IL6 had no effect on IBD LPMC production of IL17 ; however, IL12 markedly increased IFNgamma production and decreased IL17 production
Wong et al., Eur Respir J 2010 (Asthma...) : Such induction was synergistically enhanced by IL-17A, and direct interaction between these two cells was necessary for IL-17A induced IL-6 and CCL2 release
Hillyer et al., Rheumatology (Oxford) 2009 (Arthritis, Rheumatoid) : IL-17A protein was detected in approximately 40 % of the supernatants and IL-17A blockade, in IL-17A producing cultures, resulted in a small but significant inhibition of TNF-alpha ( 38 % ), IL-1beta ( 23 % ) and IL-6 ( 22 % )
Passos et al., J Immunol 2010 (Acute Disease...) : IL-6 promotes NK cell production of IL-17 during toxoplasmosis
Mus et al., Arthritis Rheum 2010 (Arthritis, Experimental) : In contrast, transforming growth factor beta1 ( TGFbeta1 ) /IL-6 was a potent inducer of RORgammat, RORalpha, IL-17A , IL-17F, IL-21, and FoxP3 in these cells
Ma et al., J Immunol 2010 : The NF-kappaB pathway inhibitor BAY-11, JNK inhibitor JNKi II, and p38 inhibitor SB203580 suppressed the synergistic effect of IL-6 and IL-17 on IL-6 expression
Baldeviano et al., Circ Res 2010 (Cardiomyopathies...) : Flow cytometric and cytokine analysis revealed an important role for IL-17A in heart-specific upregulation of IL-6 , TNFalpha, and IL-1beta and the recruitment of CD11b ( + ) monocyte and Gr1 ( + ) granulocyte populations into the heart
Yoshimura et al., J Biochem 2010 (Inflammation) : For example, TGF-beta induces Foxp3 positive regulatory T cells ( iTregs ) in the presence of interleukin-2 (IL-2), while in the presence of IL-6 , it induces pathogenic IL-17 producing Th17 cells
Toh et al., Ann Rheum Dis 2010 (Arthritis, Rheumatoid) : Effects of IL-17 or IFNgamma on IL-6 , IL-1, IL-8, matrix metalloproteinase-8 (MMP-8) were measured by real-time RT-PCR in RA synovial cells ... In RA synovial cells, IL-17 induced IL-6 , IL-1, IL-8 and MMP-8, whereas IFNgamma had minimal or inhibitory effects
Vazquez-Tello et al., Clin Exp Allergy 2010 (Asthma) : The expression of IL-6 in response to IL-17A and F and dexamethasone was determined by Q-RT-PCR using primary airway epithelial cells from normal and asthmatic subjects ... Dexamethasone significantly decreased the IL-17 induced IL-6 expression in cells from normal individuals but not in those from asthmatics ( P < or =0.05 )
Zhang et al., Arch Oral Biol 2010 : The expression of COX-2, IL-1alpha, IL-6 , IL-8, IL-11, and TNF-alpha, as well as PGE ( 2 ) production increased in the presence of IL-17A , whereas COX-1 expression did not change ... Celecoxib blocked the stimulatory effect of IL-17A on the expression of COX-2, IL-1alpha, IL-6 , IL-8, and IL-11 as well as PGE ( 2 ) production, whereas it did not block TNF-alpha expression
Yoshimura et al., Curr Top Microbiol Immunol 2011 : TGF-ß induces Foxp3 positive regulatory T cells ( iTregs ), while in the presence of IL-6 , it induces pathogenic IL-17 producing Th17 cells
Grainger et al., J Exp Med 2010 (Chronic Disease...) : HES induced IL-17 in the presence of IL-6 but did not promote Th1 or Th2 development under any conditions
Bian et al., Stem Cells 2010 (Inflammation) : Exogenous IL-17A stimulated the expression and production of inflammatory cytokines ( TNF-a, IL-6 , and IL-1ß ) and chemokine IL-8 by HLECs
Zhang et al., Beijing Da Xue Xue Bao 2010 (Chlamydia Infections...) : IL-17 was produced early in airway upon Chlamydia trachomatis, and rmIL-17could induce IL-6 and MIP-2 production in L929 cells after infection with MoPn
Freches et al., Clinical and vaccine immunology : CVI 2011 (Tuberculosis) : Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice ... Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6) , and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice
Hot et al., Ann Rheum Dis 2011 (Arthritis, Rheumatoid) : Inhibition of either IL-17RA or IL-17RC expression via siRNA led to near complete abrogation of IL-6 expression mediated by IL-17A and the combination of IL-17F and tumour necrosis factor a
Chen et al., Osteoarthritis Cartilage 2011 (Disease Models, Animal...) : Our results suggest that RA10-6 can inhibit synovial inflammation by blocking IL-17/IL-17RA mediated IL-6 expression
Chen et al., PloS one 2011 : IL-17A significantly enhanced the production of CXCL8, CCL2, CCL20 and IL-6 by these cells
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011 : This study was aimed to investigate the effect of grape seed proanthocyanidin extract ( GSPE ) on interleukin-17 (IL-17) induced interleukin-6 (IL-6) production in A549 human pulmonary epithelial cells ... Our results show that GSPE may inhibit IL-17 stimulated IL-6 productions in human pulmonary epithelial cells by inhibiting MAPK and nuclear factor-?B mediated signaling pathway
Guo et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011 : The results showed that as compared to control group, IL-17 protein level in the supernatants of CD4 ( + ) T cells significantly increased in IL-6 stimulated group : ( 337.05 ± 189.09 pg/ml ; vs 15.07 ± 12.70 pg/ml ) ( p < 0.05 )
Ogita et al., Int J Mol Med 2011 : Stimulation with TGF-ß plus IL-6 increased mRNA expression of IL-17 and its production in the splenocytes, but ST28 markedly suppressed both
Barry et al., Int J Cardiol 2013 (Myocardial Reperfusion Injury) : In addition, IL-17A promoted the expression of Cxcl1 and IL-6 in isolated cardiomyocytes in a MAPK and PI(3)K dependent manner
Wang et al., J Clin Pathol 2012 (Hemangioma...) : Notably, IL-17 , when added to cell cultures of human umbilical cord derived endothelial cells, had an effect on the secretion of IL-6 and p-stat3 ... Based on these findings, we propose that IL-17 may mediate the angiogenesis in a IL-6-Stat3 dependent manner and play an important role in the pathophysiology of hepatic haemangioma
Kotobuki et al., Pigment Cell Melanoma Res 2012 (Autoimmune Diseases...) : In terms of local cytokine network in the skin, IL-17A dramatically induced IL-1ß, IL-6 , and TNF-a production in skin-resident cells such as keratinocytes and fibroblasts
Gu et al., Molecular cancer 2011 (Carcinoma, Hepatocellular...) : IL-17 induces AKT dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Hayashi et al., Oral Dis 2012 (Root Resorption) : Furthermore, the effects of IL-17 on IL-6 release were investigated using human PDL cells in vitro ... IL-17 increased the release of IL-6 from human periodontal ligament cells in a time dependent manner
Perona-Wright et al., J Immunol 2012 (Schistosomiasis) : This schistosome-specific IL-17 was dependent on IL-6 production by the copulsed dendritic cells
Meares et al., Glia 2012 : IL-17 enhances IL-6 signaling and subsequent IL-6 expression in astrocytes
Yoh et al., Eur J Immunol 2012 (Purpura, Hyperglobulinemic...) : In the present study, polyclonal plasmacytosis in BALB/F1 ROR?t Tg mice appeared to be due to the induction of excessive IL-6 production by IL-17
Xu et al., Mucosal Immunol 2012 (Simian Acquired Immunodeficiency Syndrome) : IL-17 production by ILCs was induced by IL-6 , transforming growth factor-ß, and IL-23
Zhang et al., World J Gastroenterol 2012 (Inflammation...) : Lentiviral vector mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6 ... IL-6 expression induced by IL-17A was significantly increased compared to control in HSCs ( P < 0.01 in a dose dependent manner ) ... Suppression of IL-17RA using lentiviral mediated shRNA inhibited IL-6 expression induced by IL-17A compared to group with only IL-17A treatment ( 1.44 ± 0.17 vs 4.07 ± 0.43, P < 0.01 ) ... Moreover, Lentiviral mediated IL-17RA shRNA 1 inhibited IL-17A induced IL-6 mRNA expression compared to random shRNA in HSCs ( 1.44 ± 0.17 vs 3.98 ± 0.68, P < 0.01 ) ... Down-regulation of the IL-17RA receptor by shRNA decreased IL-6 expression induced by IL-17A via p38 MAPK and ERK1/2 phosphorylation in HSCs. Suppression of IL-17RA expression may be a strategy to reduce the inflammatory response induced by IL-17A in the liver
Giambartolomei et al., Am J Pathol 2012 (Brucellosis) : Neutralization experiments indicated that IL-6 , generated by Brucella infection, induced the production of pro-osteoclastogenic IL-17 from LTs
Hot et al., Ann Rheum Dis 2013 (Atherosclerosis...) : Simvastatin decreased IL-17 induced IL-6 , IL-8, CX3CL-1, RANTES mRNA and CX3CL-1 and CCL20 production
Choi et al., J Invest Dermatol 2013 (Hypopigmentation) : Despite the lack of a direct inhibition of melanin pigment synthesis, IFN? and IL-17A increased the synthesis of an antimelanogenic cytokine IL-6 in NHMs. IFN? activated signal transducers and activators of transcription 1 ( STAT1 ) and STAT3 phosphorylation in NHMs, and IL-4 increased the STAT3 and STAT6 phosphorylation
Mellett et al., Nature communications 2012 : In contrast, interleukin-17 receptor D deficiency results in enhanced interleukin-17A induced activation of nuclear factor-kappa B and interleukin-6 and keratinocyte chemoattractant expression
Guan et al., Immunotherapy 2012 (Colitis) : In vitro inhibition tests of sera from vaccine immunized mice were performed using IL-17 induced IL-6 production by NIH 3T3 cells and IL-17 induced TNF production by macrophages ... Furthermore, in vitro study revealed that serum IL-17-specific IgG from vaccine immunized mice significantly enhanced IL-17 induced IL-6 production and IL-17 induced TNF production dose-dependently
Moon et al., Exp Mol Med 2013 (Pneumonia) : Moreover, the production of IL-6 from inflammatory cells, induced by IL-17 , was abolished by treatment with ASA, whereas that induced by LPS was not
Shimizu et al., Eur J Oral Sci 2013 (Dermatitis, Atopic...) : In addition, CD4 ( + ) T cells, including IL-17 production cells, were obtained from patients with AD and from healthy donors, and the effects of IL-17 on the production of IL-6 and IL-8 were investigated using a co-culture of CD4 ( + ) T cells with human dental pulp ( hDP ) cells stimulated with substance P ( SP )
Li et al., Cell Immunol 2013 (Graves Disease) : These changes facilitate the IL-17 mediated upregulation of IL-6 , CXCL10, and ICAM-1
Yang et al., Clin Dev Immunol 2013 (Arthritis, Experimental...) : Baicalin also blocked IL-17 induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6 , and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes
Yao et al., Immunity 1995 : Recombinant HVS13 and CTLA8 stimulate transcriptional factor NF-kappa B activity and interleukin-6 (IL-6) secretion in fibroblasts, and costimulate T cell proliferation
Kennedy et al., J Interferon Cytokine Res 1996 : Mouse, rat, and human IL-17 can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor
Chabaud et al., J Immunol 1998 (Arthritis, Rheumatoid) : Enhancing effect of IL-17 on IL-1 induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines
Aarvak et al., J Immunol 1999 (Arthritis, Rheumatoid...) : In rheumatoid arthritis synovial tissue, high levels of IL-17 contribute to IL-6 production by synoviocytes