J Immunol 2010,
PMID: 20083665
Passos, Sara T; Silver, Jonathan S; O'Hara, Aisling C; Sehy, David; Stumhofer, Jason S; Hunter, Christopher A
Previous studies have implicated T cell production of IL-17 in resistance to Toxoplasma gondii as well as the development of immune-mediated pathology during this infection. Analysis of C57BL/6 and C57BL/6 RAG(-/-) mice challenged with T. gondii-identified NK cells as a major innate source of IL-17. The ability of soluble Toxoplasma Ag to stimulate NK cells to produce IL-17 was dependent on the presence of accessory cells and the production of IL-6, IL-23, and TGF-beta. In contrast, these events were inhibited by IL-2, IL-15, and IL-27. Given that IL-6 was one of the most potent enhancers of NK cell production of IL-17, further studies revealed that only a subset of NK cells expressed both chains of the IL-6R, IL-6 upregulated expression of the Th17-associated transcription factor RORgammat, and that IL-6(-/-) mice challenged with T. gondii had a major defect in NK cell production of IL-17. Together, these data indicate that many of the same cytokines that regulate Th17 cells are part of a conserved pathway that also control innate production of IL-17 and identify a major role for IL-6 in the regulation of NK cell responses.
Diseases/Pathways annotated by Medline MESH: Acute Disease, Toxoplasmosis, Animal
Document information provided by NCBI PubMed
Text Mining Data
IL-17 → IL-6: "
IL-6 promotes NK cell production of
IL-17 during toxoplasmosis
"
Manually curated Databases
No curated data.