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EGF — SMAD3

Text-mined interactions from Literome

Kretzschmar et al., Genes Dev 1999 (Cell Transformation, Neoplastic...) : EGF , which is weaker than oncogenic mutations at activating Ras, induces a less extensive phosphorylation and cytoplasmic retention of Smad2 and Smad3
Peron et al., J Biol Chem 2001 : Whereas inhibition of JNK had no effect, inhibition of the phosphatidylinositol-3 ' kinase ( PI3-kinase ) pathway by LY294002 or by expression of a dominant negative mutant of PI3-kinase reduced EGF/TGF-beta induced Smad3 transcriptional activity ... The EGF/TGF-beta induced activation of Smad3 correlated with PI3-kinase and p38 dependent but not JNK dependent phosphorylation of c-Jun
Esguerra et al., Development 2007 : Stimulation of Alk4/EGF-CFC receptor complexes by Nodal activates Smad2/3 , leading to left sided expression of target genes that promote asymmetric placement of certain internal organs
Yang et al., Am J Physiol Lung Cell Mol Physiol 2008 (MAP Kinase Signaling System) : We show that EGF does not prevent the TGF-beta induced nuclear accumulation of Smad2/3 ; rather, EGF stabilizes the short lived Smad transcriptional corepressor TG-interacting factor (TGIF) via EGFR/Mek/Erk mediated phosphorylation of TGIF
Diamond et al., J Cell Sci 2008 (Carcinoma, Squamous Cell...) : Mechanistically, EGF enhanced Smad phosphorylation in the linker region, and attenuated TGFbeta1 mediated phosphorylation of Smad at the C-terminus, localization of Smad to the nucleus as well as Smad-driven promoter activity exclusively in oral keratinocytes but not in OSCC cells ... The effect of EGF on TGFbeta1 mediated Smad-driven promoter activity and N-cadherin expression was reversed when activation of ERK1/2 was blocked
Matsuura et al., J Biol Chem 2010 (Neoplasm Invasiveness...) : Although epidermal growth factor also induces phosphorylation of threonine 179 and other residues in the Smad3 linker region the same as TGF-beta, Pin1 is unable to bind to the epidermal growth factor stimulated Smad3
Kim et al., Cancer Lett 2012 (Breast Neoplasms) : EGF induced the phosphorylation of EGFR, smad3 , ERK, and JNK, and MMP-9 expression was decreased by the EGFR inhibitor, AG1478 ... Interestingly, EGF induced smad3 phosphorylation was completely blocked by smad7 over-expression, but not the phosphorylation of ERK and JNK ... This study showed that EGF induced smad3 phosphorylation mediates the induction of MMP-9, whereas smad7 inhibits TGF-ß1 as well as the EGF signaling pathway in SKBR3 cells
Iwayama et al., Nephron extra 2011 : Inhibition of p38MAPK but not of ERK abolished the protective effect of EGF on CyA induced nuclear translocation of p-Smad2/3 and apoptosis
de Caestecker et al., Genes Dev 1998 : We demonstrate here that HGF and EGF , which signal through RTKs, can also mediate SMAD dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase ( s ) downstream of MEK1