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MMP-9 — smad7: " We determined the effect of smad7 on EGF induced MMP-9 expression in SKBR3 breast cancer cells "
smad7 → EGF: " The expression of smad7 and MMP-9 was increased by EGF or TGF-ß1, respectively, and further increased by EGF and TGF-ß1 co-treatment "
MMP-9 → EGF: " The expression of smad7 and MMP-9 was increased by EGF or TGF-ß1, respectively, and further increased by EGF and TGF-ß1 co-treatment "
EGF → EGFR: " EGF induced the phosphorylation of EGFR , smad3, ERK, and JNK, and MMP-9 expression was decreased by the EGFR inhibitor, AG1478 "
EGF → ERK: " EGF induced the phosphorylation of EGFR, smad3, ERK , and JNK, and MMP-9 expression was decreased by the EGFR inhibitor, AG1478 "
EGF → smad3: " EGF induced the phosphorylation of EGFR, smad3 , ERK, and JNK, and MMP-9 expression was decreased by the EGFR inhibitor, AG1478 "
smad3 ⊣ SIS3: " In addition, EGF induced MMP-9 expression was inhibited by UO126 ( a MEK1/2 inhibitor ) or SIS3 ( a smad3 inhibitor ), but not by SP600125 ( a JNK inhibitor ) "
MMP-9 ⊣ SIS3: " In addition, EGF induced MMP-9 expression was inhibited by UO126 ( a MEK1/2 inhibitor ) or SIS3 ( a smad3 inhibitor ), but not by SP600125 ( a JNK inhibitor ) "
MMP-9 → EGF: " In addition, EGF induced MMP-9 expression was inhibited by UO126 ( a MEK1/2 inhibitor ) or SIS3 ( a smad3 inhibitor ), but not by SP600125 ( a JNK inhibitor ) "
smad3 ⊣ ERK: " Interestingly, EGF induced smad3 phosphorylation was completely blocked by smad7 over-expression, but not the phosphorylation of ERK and JNK "
smad3 → EGF: " Interestingly, EGF induced smad3 phosphorylation was completely blocked by smad7 over-expression, but not the phosphorylation of ERK and JNK "
MMP-9 → EGF: " We also investigated the role of smad3 on EGF induced MMP-9 expression and showed that EGF induced MMP-9 expression was decreased by smad3 siRNA transfection, whereas EGF induced MMP-9 expression was further increased by smad3 over-expression, as expected "
MMP-9 — smad3: " We also investigated the role of smad3 on EGF induced MMP-9 expression and showed that EGF induced MMP-9 expression was decreased by smad3 siRNA transfection, whereas EGF induced MMP-9 expression was further increased by smad3 over-expression, as expected "
smad3 → EGF: " This study showed that EGF induced smad3 phosphorylation mediates the induction of MMP-9, whereas smad7 inhibits TGF-ß1 as well as the EGF signaling pathway in SKBR3 cells "
MMP-9 → smad3: " This study showed that EGF induced smad3 phosphorylation mediates the induction of MMP-9 , whereas smad7 inhibits TGF-ß1 as well as the EGF signaling pathway in SKBR3 cells "