◀ Back to IL12A

IL12A — IL17A

Text-mined interactions from Literome

Aggarwal et al., J Biol Chem 2003 : In contrast to IL-23, IL-12 had only marginal effects on IL-17 production
Hoeve et al., Eur J Immunol 2006 (Arthritis...) : Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells ... In contrast, IL-12 mediated specific inhibition of IL-17 production
Wheeler et al., Immunology 2006 (Encephalomyelitis, Autoimmune, Experimental) : There was greater expression of IL-12/23p40 by antigen presenting cells in these mice, and in vitro, TNFR1-/- antigen presenting cells induced greater secretion of IFN-gamma but not interleukin (IL)-17 when cultured with primed T cells than did WT antigen presenting cells
Nakae et al., J Leukoc Biol 2007 : We found that IL-23 or IL-17 can suppress Th1 cell differentiation in the presence of exogenous IL-12 in vitro
Sheibanie et al., J Immunol 2007 (Colitis...) : We assessed the effects of PGE ( 2 ) on IL-12, IL-27, and IL-23 and found that PGE ( 2 ) promotes IL-23, inhibits IL-12 and IL-27 expression and release from stimulated DCs, and subsequently induces IL-17 production in activated T cells
Reddy et al., Cell Immunol 2007 : CNTO 1275 inhibited upregulation of CLA, IL-12R , IL-2Ralpha and CD40L expression and also inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A , tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Romagnani et al., Arthritis Res Ther 2008 (Autoimmune Diseases) : Moreover, the presence in the circulation and in various tissues of Th cells that can produce both IL-17 and interferon-gamma, as well as the flexibility of human Th17 clones to produce interferon-gamma in addition to IL-17 in response to IL-12 , suggests that there may be a developmental relationship between Th17 and Th1 cells, at least in humans
Takedatsu et al., Gastroenterology 2008 (Chronic Disease...) : Furthermore, IFN-gamma and IL-17 production from CD4 ( + ) T cells, induced by IL-12 and IL-23 respectively, was enhanced synergistically by combination with TL1A
Mo et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental...) : Signal transducer and activator of transcription 4 ( Stat4 ) is a transcription factor activated by IL-12 and IL-23, two cytokines known to play important roles in the pathogenesis of EAE by inducing T cells to secrete IFN-gamma and IL-17 , respectively
Lemos et al., Proc Natl Acad Sci U S A 2009 (Arthritis, Rheumatoid...) : Our results suggest that prostaglandin plays an important role in IL-23 induced neutrophil migration in arthritis by enhancing IL-17 synthesis and by inhibiting IL-12 and IFNgamma production
Rovedatti et al., Gut 2009 (Colitis, Ulcerative...) : IL23 and IL1beta plus IL6 had no effect on IBD LPMC production of IL17 ; however, IL12 markedly increased IFNgamma production and decreased IL17 production ... Our findings support a role for IL12 , TGFbeta and IL21 in modulating IL17/IFNgamma production in IBD
Lin et al., Immunity 2009 (Tularemia) : Furthermore, we show that IL-17A also induced IL-12 and interferon-gamma production in macrophages and mediated bacterial killing
Clarke et al., MAbs 2010 : Antibodies with this unique mechanism of inhibition are potent inhibitors of IL-12 induced IFN-? production and IL-23 induced IL-17 production in vitro, and in an in vivo model of psoriasis, treatment with a humanized variant of this antibody, h6F6, reduced the inflammatory response, resulting in decreased epidermal hyperplasia
Feng et al., J Immunol 2011 (Colitis) : Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production ... IL-17 promoted dendritic cell production of IL-12 and IL-23 ... Collectively, these data indicate that Th17 cells convert to Th1 cells through IL-17 induction of mucosal innate IL-12 and IL-23 production
Gopal et al., Eur J Immunol 2012 (Disease Models, Animal...) : The ability of IL-17 to downregulate IL-10 and induce IL-12 production allows the generation of subsequent Th1-cell responses
Awoniyi et al., PloS one 2012 (Salmonella Infections) : IL-12 and IL-23 regulate innate and adaptive immunity to microbial pathogens through influencing the expression of IFN-?, IL-17 , and IL-22
Zhong et al., Blood 2012 (Purpura, Thrombocytopenic, Idiopathic) : Th-1 polarizing cytokine IL-12 , secreted after direct contact of patient T-cell and CD16 ( + ) monocytes, was responsible for the inhibitory effect on Treg and IL-17 ( + ) CD4 ( + ) cell proliferation
Rasouli et al., Cytokine 2013 (Brucellosis...) : It is also clarified that IL-17 is required for the induction of IFN-? and IL-12 in macrophages and dendritic cells