J Biol Chem 2003,
PMID: 12417590
Aggarwal, Sudeepta; Ghilardi, Nico; Xie, Ming-Hong; de Sauvage, Frederic J; Gurney, Austin L
Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the regulation of its expression is not well characterized. We observe that IL-17 production is increased in response to the recently described cytokine IL-23. We present evidence that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion. IL-23 also induced expression of the related cytokine IL-17F. IL-23 is a heterodimeric cytokine and shares a subunit, p40, with IL-12. In contrast to IL-23, IL-12 had only marginal effects on IL-17 production. These data suggest that during a secondary immune response, IL-23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.
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Text Mining Data
IL-17 → IL-23: "
We observe that
IL-17 production is increased in
response to the recently described cytokine
IL-23
"
IL-17F → IL-23: "
IL-23 also induced expression of the related cytokine IL-17F
"
IL-17 → IL-12: "
In contrast to IL-23, IL-12 had only marginal effects on IL-17 production
"
Manually curated Databases
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (dimer ) complex (STAT3)
→
IL17 (IL17A)
(transcription, activates)
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (dimer ) complex (STAT3)
→
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(transcription, activates)
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (dimer ) complex (STAT3)
→
IL17F (IL17F)
(transcription, activates)
Evidence: mutant phenotype, other species
In total, 8 gene pairs are associated to this article in curated databases