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ARPC3 — WASF2

Pathways - manually collected, often from reviews:

• BioCarta y branching of actin filaments: ARP2/3/WAVE1-3/HSPC complex (ACTR2-ACTR3-ARPC1A-ARPC1B-ARPC2-ARPC3-ARPC4-WASF2-PSMA7) → ARP2/3 complex (ACTR2-ACTR3-ARPC1A-ARPC1B-ARPC2-ARPC3-ARPC4) (modification, collaborate)
  
• BioCarta y branching of actin filaments: ARP2/3/WAVE1-3/HSPC complex (ACTR2-ACTR3-ARPC1A-ARPC1B-ARPC2-ARPC3-ARPC4-WASF2-PSMA7) → WAVE1-3/HSPC complex (WASF2-PSMA7) (modification, collaborate)
  
• BioCarta y branching of actin filaments: ARP2/3 complex (ACTR2-ACTR3-ARPC1A-ARPC1B-ARPC2-ARPC3-ARPC4) → WAVE1-3/HSPC complex (WASF2-PSMA7) (modification, collaborate)
  
• KEGG Fc gamma R-mediated phagocytosis: WASF1/WASF2/WASF3 → ARPC1A/ARPC1B/ARPC2/ARPC3/ARPC4/ARPC5/ARPC5L (protein-protein, activation)
  
• KEGG Regulation of actin cytoskeleton: WASF2 → ARPC1A/ARPC1B/ARPC2/ARPC3/ARPC4/ARPC5/ARPC5L (protein-protein, activation)
  
• KEGG Bacterial invasion of epithelial cells: WASF1/WASF2 → ARPC1A/ARPC1B/ARPC2/ARPC3/ARPC4/ARPC5/ARPC5L (protein-protein, activation)
  
• KEGG Bacterial invasion of epithelial cells: WASF1/WASF2 → ARPC1A/ARPC1B/ARPC2/ARPC3/ARPC4/ARPC5/ARPC5L (protein-protein, activation)
  
• KEGG Shigellosis: WASF1/WASF2 → ARPC1A/ARPC1B/ARPC2/ARPC3/ARPC4/ARPC5/ARPC5L (protein-protein, activation)
  
• NCI Pathway Database PDGFR-beta signaling pathway: WAVE2/Nap1/Sra1/ABI1/HSPC300 complex (WASF2-NCKAP1-CYFIP2-ABI1-BRK1) → Arp2/3 complex complex (ACTR2-ACTR3-ARPC1B-ARPC2-ARPC3-ARPC4-ARPC5) (modification, activates)
  Innocenti et al., Nat Cell Biol 2004, Leng et al., Proc Natl Acad Sci U S A 2005
  Evidence: mutant phenotype, assay
• NCI Pathway Database RAC1 signaling pathway: WAVE2/Nap1/Sra1/ABI1/HSPC300 complex (WASF2-NCKAP1-CYFIP2-ABI1-BRK1) → Arp2/3 complex complex (ACTR2-ACTR3-ARPC1B-ARPC2-ARPC3-ARPC4-ARPC5) (modification, activates)
  Yamazaki et al., J Cell Sci 2007, Bosse et al., Mol Cell Biol 2007, Ryu et al., Mol Cell Biol 2009
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB1 downstream signaling: WAVE2/Nap1/Sra1/ABI1/HSPC300 complex (WASF2-NCKAP1-CYFIP2-ABI1-BRK1) → Arp2/3 complex complex (ACTR2-ACTR3-ARPC1B-ARPC2-ARPC3-ARPC4-ARPC5) (modification, activates)
  Innocenti et al., Nat Cell Biol 2004
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: ARPC3 → WASF2 (indirect_complex) Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001
• Reactome Reaction: ARPC3 → WASF2 (reaction) Takenawa et al., J Cell Sci 2001, Zalevsky et al., Curr Biol 2001, Le Clainche et al., Proc Natl Acad Sci U S A 2003, Kovar et al., Nat Cell Biol 2006

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Ophid Interaction: WASF2 — ARPC3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Suetsugu et al., J Cell Sci 2001 (Wiskott-Aldrich Syndrome) : We found that the branching of actin filaments on pre existing ADP filaments mediated by the Arp2/3 complex is twice as efficient when Arp2/3 was activated by wild-type neural WASP (N-WASP) or WASP-family verprolin-homologous protein (WAVE) 2 than when activated by the VCA domain alone
Suetsugu et al., J Cell Biol 2006 : WAVE2 activates the actin related protein (Arp) 2/3 complex for Rac induced actin polymerization during lamellipodium formation and exists as a large WAVE2 protein complex with Sra1/PIR121, Nap1, Abi1, and HSPC300
Nakanishi et al., J Biochem 2007 : Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex