Gene interactions and pathways from curated databases and text-mining

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IL2 — SHC1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Pratt et al., J Immunol 1999 : In addition, we found that Shc-SH2 and Shc-Y239/240F, but not Shc-Y317F, inhibited phosphorylation of extracellular signal regulated protein kinase and production of IL-2 after TCR cross linking
Iwashima et al., Proc Natl Acad Sci U S A 2002 : Genetic evidence for Shc requirement in TCR induced c-Rel nuclear translocation and IL-2 expression ... These results show that Shc plays an essential role in the TCR induced activation of c-Rel and the IL-2 promoter
Fukushima et al., Cell Signal 2006 : Inhibition of the Lck/Shc interaction led to the loss of IL-2 promoter activation, confirming that the role of Shc in IL-2 production requires its interaction with Lck
Matsuguchi et al., J Biol Chem 1994 (Leukemia, Megakaryoblastic, Acute) : Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL
Dorsch et al., Eur J Immunol 1994 : Gene transfer of the interleukin (IL)-2 receptor beta chain into an IL-7 dependent pre-B cell line permits IL-2-driven proliferation : tyrosine phosphorylation of Shc is induced by IL-2 but not IL-7 ... Shc tyrosine phosphorylation as a result of IL-2 stimulation was consistently found in CTLL-2 cells and human T lymphoblasts
Zhu et al., J Biol Chem 1994 : Interleukin-2 induced tyrosine phosphorylation of Shc proteins correlates with factor dependent T cell proliferation ... IL-2 induced tyrosine phosphorylation of Shc was detectable within seconds following IL-2 addition, reaching its highest level by 15 min. Tyrosine phosphorylation of Shc was induced in multiple IL-2 dependent T cell lines and was found to correlate with IL-2 dependent cell proliferation
Ravichandran et al., J Biol Chem 1994 : Since the adapter protein Shc acts upstream of Ras and is involved in T cell receptor mediated Ras activation, we examined the role of Shc in IL-2 signaling
Ravichandran et al., Proc Natl Acad Sci U S A 1996 : Furthermore, when wild type or mutant Shc proteins that lack the PTB domain were expressed in the IL-2 dependent CTLL-20 cell line, an intact Shc-PTB domain was required for Shc phosphorylation by the IL-2R , which provides further support for a Shc-PTB-IL-2R interaction in vivo
Friedmann et al., Proc Natl Acad Sci U S A 1996 : While Y392 and Y510 were critical for IL-2 induced activation of signal transducers and activators of transcription ( STAT proteins ), Y338 was required for Shc-IL-2Rbeta association and for IL-2 induced tyrosine phosphorylation of Shc
Barber et al., Blood 1997 : Although stimulation with IL-2 or IL-15 resulted in the rapid, dose dependent tyrosine phosphorylation of Shc , stimulation with EPO failed to activate Shc