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GAB2 — PIK3R1

Pathways - manually collected, often from reviews:

• KEGG Fc gamma R-mediated phagocytosis: GAB2 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, binding/association)
  
• KEGG Chronic myeloid leukemia: GAB2 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Augustine et al., Mol Cell Biol 1991, Gómez et al., J Immunol 1997
  Evidence: assay, other species
• NCI Pathway Database IL2 signaling events mediated by PI3K: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PKC zeta (PRKCZ) (modification, activates) Gómez et al., Exp Cell Res 1995, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: GAB2/PI3K/SHP2 complex (GAB2-PTPN11-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates)
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database SHP2 signaling: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates) Jee et al., J Invest Dermatol 2002
  Evidence: mutant phenotype
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL2 signaling events mediated by PI3K: None → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Gu et al., Mol Cell Biol 2000, Lindemann et al., J Biol Chem 2003, Akbar et al., Eur J Immunol 1996, Ahmed et al., Proc Natl Acad Sci U S A 1997, Reif et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Antigen/IgE/Fc epsilon R1/Fyn complex (FYN-FCER1A-MS4A2-IGHE-FCER1G) → GAB2/PI3K/SHP2 complex (GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: GAB2 (GAB2) → GAB2/PI3K/SHP2 complex (GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: GAB2 (GAB2) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: SHP2 (PTPN11) → GAB2/PI3K/SHP2 complex (GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  
• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: GAB2/PI3K/SHP2 complex (GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11) (modification, collaborate)
  Gadina et al., J Biol Chem 2000, Gu et al., Mol Cell Biol 2000, Merida et al., J Immunol 1991, Truitt et al., J Biol Chem 1994, Kanazawa et al., Cell Immunol 1994, Gómez et al., J Immunol 1997, Gadina et al., J Immunol 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
  Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL2-mediated signaling events: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, other species
• NCI Pathway Database SHP2 signaling: RAF1 (RAF1) → IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) (modification, activates)
  Blanchard et al., Oncogene 2000, Lundin Brockdorff et al., Cytokine 2002, Karnitz et al., Mol Cell Biol 1995
  Evidence: mutant phenotype
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Takahashi-Tezuka et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11) → GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Takahashi-Tezuka et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL6-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1) (modification, collaborate)
  Takahashi-Tezuka et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: PIK3R1 → GAB2 (indirect_complex) Nishida et al., Blood 1999, Demiroglu et al., Blood 2001, Sattler et al., Cancer Cell 2002*, Roumiantsev et al., Cancer Cell 2004, Yu et al., J Immunol 2006, Sun et al., J Biol Chem 2008, Nishida et al., J Immunol 2011
• Reactome Reaction: PIK3R1 → GAB2 (reaction) Nishida et al., Blood 1999, Wickrema et al., J Biol Chem 1999, Demiroglu et al., Blood 2001, Sattler et al., Cancer Cell 2002*, Roumiantsev et al., Cancer Cell 2004, Yu et al., J Immunol 2006, Sun et al., J Biol Chem 2008, Nishida et al., J Immunol 2011, Gu et al., Mol Cell 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GAB2 — PIK3R1 (direct interaction, pull down) Ren et al., Mol Cell Biol 2005*
• IRef Biogrid Interaction: GAB2 — PIK3R1 (direct interaction, pull down) Momose et al., J Immunol 2003*
• IRef Biogrid Interaction: GAB2 — PIK3R1 (physical association, affinity chromatography technology) Lynch et al., EMBO J 2002*
• IRef Biogrid Interaction: GAB2 — PIK3R1 (physical association, affinity chromatography technology) Crouin et al., FEBS Lett 2001*
• IRef Biogrid Interaction: GAB2 — PIK3R1 (direct interaction, two hybrid) Crouin et al., FEBS Lett 2001*
• IRef Biogrid Interaction: GAB2 — PIK3R1 (physical association, affinity chromatography technology) Schaeper et al., J Cell Biol 2000
• IRef Hprd Interaction: GAB2 — PIK3R1 (in vitro) Nishida et al., Blood 1999, Ren et al., Exp Hematol 2005*
• IRef Hprd Interaction: GAB2 — PIK3R1 (in vivo) Nishida et al., Blood 1999, Ren et al., Exp Hematol 2005*
• IRef Intact Interaction: Complex of PIK3R1-EGFR-PTPN11-GAB2-GRB2 (association, anti tag coimmunoprecipitation) Brummer et al., J Biol Chem 2006*
• IRef Intact Interaction: Complex of 37 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: GAB2 — PIK3R1 (physical association, pull down) Ren et al., Exp Hematol 2005*
• IRef Ophid Interaction: GAB2 — PIK3R1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: GAB2 — PIK3R1 (aggregation, confirmational text mining) Nishida et al., Blood 1999

Text-mined interactions from Literome

Kong et al., Mol Endocrinol 2003 : Our data demonstrate that Gab2 mediates EGF induced PI3K activation and DNA synthesis in a PH domain independent manner
Nyga et al., Biochem J 2005 : Taken together, our results indicate that Gab2 is required for caSTAT5 induced cell proliferation by regulating both the PI3K/Akt and the Ras/MAPK pathways
Maus et al., Cell Signal 2009 : It has been shown in several model systems that Gab/Dos family members may regulate both the anti-apoptotic PI3-K/Akt and the mitogenic Ras/MAPK pathways, still their role in B-cells have not been investigated in detail