UCSC Mouse Gene Sorter

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UCSC Mouse Gene Sorter

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#	Name	VisiGene	BLASTP E-Value	Genome Position	Description
1	Pak1	179465	0	chr7 97,850,212	ATP + a protein = ADP + a phosphoprotein. (from UniProt G5E884)
2	Pak3	154127	0	chrX 143,731,041	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. (from UniProt Q61036)
3	Pak2	n/a	0	chr16 32,047,816	Mus musculus p21 (RAC1) activated kinase 2 (Pak2), mRNA. (from RefSeq NM_177326)
4	Pak4	179468	4e-91	chr7 28,578,502	Mus musculus p21 (RAC1) activated kinase 4 (Pak4), mRNA. (from RefSeq NM_027470)
5	Pak7	n/a	5e-91	chr2 136,234,521	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity). (from UniProt Q8C015)
6	Pak6	179469	6e-85	chr2 118,680,661	Mus musculus p21 (RAC1) activated kinase 6 (Pak6), transcript variant 1, mRNA. (from RefSeq NM_001033254)
7	Stk3	n/a	8e-68	chr15 35,015,651	Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 1, mRNA. (from RefSeq NM_019635)
8	Stk4	188098	1e-65	chr2 164,114,831	Mus musculus serine/threonine kinase 4 (Stk4), mRNA. (from RefSeq NM_021420)
9	Stk26	171701	1e-63	chrX 50,867,072	Mus musculus serine/threonine kinase 26 (Stk26), transcript variant 1, mRNA. (from RefSeq NM_133729)
10	Stk25	188093	4e-63	chr1 93,627,736	Mus musculus serine/threonine kinase 25 (yeast) (Stk25), mRNA. (from RefSeq NM_021537)
11	Stk24	188092	1e-61	chr14 121,332,838	Mus musculus serine/threonine kinase 24 (Stk24), mRNA. (from RefSeq NM_145465)
12	Map4k2	178631	2e-57	chr19 6,348,387	Mus musculus mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2), transcript variant 3, non-coding RNA. (from RefSeq NR_117093)
13	Map4k3	178632	4e-57	chr17 80,654,305	Mus musculus mitogen-activated protein kinase kinase kinase kinase 3 (Map4k3), transcript variant 1, mRNA. (from RefSeq NM_001290345)
14	Slk	181056	3e-57	chr19 47,611,237	Mus musculus STE20-like kinase (Slk), transcript variant 1, mRNA. (from RefSeq NM_009289)
15	Map4k5	186301	2e-56	chr12 69,848,461	Mus musculus mitogen-activated protein kinase kinase kinase kinase 5 (Map4k5), mRNA. (from RefSeq NM_201519)
16	Taok1	171880	1e-55	chr11 77,568,488	Mus musculus TAO kinase 1 (Taok1), transcript variant 3, mRNA. (from RefSeq NM_144825)
17	Stk10	181291	3e-53	chr11 32,578,946	Mus musculus serine/threonine kinase 10 (Stk10), transcript variant 1, mRNA. (from RefSeq NM_009288)
18	Myo3a	179066	4e-53	chr2 22,422,877	Mus musculus myosin IIIA (Myo3a), mRNA. (from RefSeq NM_148413)
19	Tnik	n/a	8e-53	chr3 28,465,893	Mus musculus TRAF2 and NCK interacting kinase (Tnik), transcript variant 1, mRNA. (from RefSeq NM_026910)
20	Oxsr1	179422	5e-53	chr9 119,280,429	Mus musculus oxidative-stress responsive 1 (Oxsr1), transcript variant 2, non-coding RNA. (from RefSeq NR_045693)
21	Map4k1	178630	7e-53	chr7 28,993,053	Mus musculus mitogen-activated protein kinase kinase kinase kinase 1 (Map4k1), transcript variant 1, mRNA. (from RefSeq NM_008279)
22	Taok3	172927	2e-52	chr5 117,197,673	Mus musculus TAO kinase 3 (Taok3), transcript variant 1, mRNA. (from RefSeq NM_001199685)
23	Taok2	166870	2e-52	chr7 126,877,103	Mus musculus TAO kinase 2 (Taok2), transcript variant 2, mRNA. (from RefSeq NM_001163775)
24	Mink1	n/a	1e-50	chr11 70,588,688	Mus musculus misshapen-like kinase 1 (zebrafish) (Mink1), transcript variant 2, mRNA. (from RefSeq NM_176893)
25	Stk39	181305	8e-49	chr2 68,341,356	Mus musculus serine/threonine kinase 39 (Stk39), mRNA. (from RefSeq NM_016866)
26	Myo3b	183908	2e-47	chr2 70,234,160	Mus musculus myosin IIIB (Myo3b), mRNA. (from RefSeq NM_177376)
27	Map4k4	149750	6e-47	chr1 39,963,077	Mus musculus mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), transcript variant 2, mRNA. (from RefSeq NM_008696)
28	Nrk	146563	5e-44	chrX 138,961,761	Mus musculus Nik related kinase (Nrk), mRNA. (from RefSeq NM_013724)
29	Map3k19	188624	3e-41	chr1 127,827,780	Mus musculus mitogen-activated protein kinase kinase kinase 19 (Map3k19), mRNA. (from RefSeq NM_011737)
30	Map3k3	178623	6e-40	chr11 106,120,029	Mus musculus mitogen-activated protein kinase kinase kinase 3 (Map3k3), mRNA. (from RefSeq NM_011947)
31	Map3k2	178622	4e-39	chr18 32,199,973	Mus musculus mitogen-activated protein kinase kinase kinase 2 (Map3k2), mRNA. (from RefSeq NM_011946)
32	Map3k4	186300	3e-38	chr17 12,273,208	Mus musculus mitogen-activated protein kinase kinase kinase 4 (Map3k4), transcript variant 1, mRNA. (from RefSeq NM_011948)
33	Stk36	181304	5e-36	chr1 74,619,169	Mus musculus serine/threonine kinase 36 (Stk36), mRNA. (from RefSeq NM_175031)
34	Map3k5	178624	4e-35	chr10 20,038,612	Mus musculus mitogen-activated protein kinase kinase kinase 5 (Map3k5), mRNA. (from RefSeq NM_008580)
35	Mark3	165571	4e-34	chr12 111,615,374	Mus musculus MAP/microtubule affinity regulating kinase 3 (Mark3), transcript variant 1, mRNA. (from RefSeq NM_021516)
36	Phkg2	179712	5e-34	chr7 127,578,355	Mus musculus phosphorylase kinase, gamma 2 (testis) (Phkg2), transcript variant 1, mRNA. (from RefSeq NM_026888)
37	Map3k15	174142	1e-33	chrX 160,055,892	Mus musculus mitogen-activated protein kinase kinase kinase 15 (Map3k15), mRNA. (from RefSeq NM_001163085)
38	Mark2	n/a	2e-33	chr19 7,309,173	Mus musculus MAP/microtubule affinity regulating kinase 2 (Mark2), transcript variant 1, mRNA. (from RefSeq NM_007928)
39	Map3k1	178620	5e-33	chr13 111,777,710	Mus musculus mitogen-activated protein kinase kinase kinase 1 (Map3k1), mRNA. (from RefSeq NM_011945)
40	Hunk	177153	3e-33	chr16 90,442,783	Mus musculus hormonally upregulated Neu-associated kinase (Hunk), mRNA. (from RefSeq NM_015755)
41	Dclk2	172623	2e-32	chr3 86,853,502	Mus musculus doublecortin-like kinase 2 (Dclk2), transcript variant 2, mRNA. (from RefSeq NM_027539)
42	Map3k6	178625	2e-32	chr4 133,246,873	Mus musculus mitogen-activated protein kinase kinase kinase 6 (Map3k6), mRNA. (from RefSeq NM_016693)
43	Mark4	186308	9e-32	chr7 19,441,798	Mus musculus MAP/microtubule affinity regulating kinase 4 (Mark4), transcript variant 1, mRNA. (from RefSeq NM_172279)
44	Akt2	173463	2e-31	chr7 27,616,189	Mus musculus thymoma viral proto-oncogene 2 (Akt2), transcript variant 1, mRNA. (from RefSeq NM_001110208)
45	Akt3	59031	2e-31	chr1 177,140,159	AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of alignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. (from UniProt Q9WUA6)
46	Mark1	186307	2e-31	chr1 184,948,179	Mus musculus MAP/microtubule affinity regulating kinase 1 (Mark1), mRNA. (from RefSeq NM_145515)
47	Cdkl3	184730	3e-31	chr11 52,021,193	Mus musculus cyclin-dependent kinase-like 3 (Cdkl3), transcript variant 2, mRNA. (from RefSeq NM_153785)
48	Ulk3	188524	4e-31	chr9 57,592,842	Mus musculus unc-51-like kinase 3 (Ulk3), mRNA. (from RefSeq NM_027895)
49	Camk1	174621	8e-31	chr6 113,339,054	Mus musculus calcium/calmodulin-dependent protein kinase I (Camk1), mRNA. (from RefSeq NM_133926)
50	Dclk3	174237	6e-31	chr9 111,464,099	Mus musculus doublecortin-like kinase 3 (Dclk3), mRNA. (from RefSeq NM_172928)