Gene interactions and pathways from curated databases and text-mining

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PGF — RHO

Text-mined interactions from Literome

Chen et al., Cell Mol Life Sci 2006 (Aneuploidy...) : This suggests that FP receptor activation of Rho signaling by PGF ( 2alpha ) can interfere with nuclear division
Schaafsma et al., Respir Res 2006 (Asthma...) : Increased Rho-kinase activity contributes to the allergen induced AHR to histamine and PGF2alpha after both the EAR and the LAR, which is effectively reversed by inhalation of Y-27632
Li et al., Oncogene 2013 (Brain Neoplasms...) : Here we screen the levels of some candidate-soluble factors in the serum of SCLC patients and find that SCLC patients with high levels of placental growth factor (PLGF) are prone to BM. Using in vitro blood-brain barrier model, we show that PLGF derived from SCLC cells triggers vascular endothelial growth factor receptor-1-Rho-extracellular regulated protein kinase 1/2 signaling axis activation, results in disassembly of tight junction in brain endothelial cells and promotes SCLC cell transendothelial migration