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CCR3 — IL5
Text-mined interactions from Literome
Stirling et al., Am J Respir Crit Care Med 2001
(Asthma) :
Interleukin-5 induces CD34 ( + ) eosinophil progenitor mobilization and eosinophil
CCR3 expression in asthma ... Intravenous
IL-5 increased mature eosinophil
CCR3 expression from a baseline mean fluorescence intensity ( MFI ) of 658 +/- 51.7 to 995 +/- 93.2 at 24 h ( p < 0.05 ), but had no effect on interleukin-5 receptor subunit alpha or CD11b expression
Gregory et al., J Immunol 2003
:
CCR3 expression was down-regulated by IL-3 and was transiently
reduced by
IL-5 and GM-CSF, but rapidly returned toward baseline
Catley et al., IDrugs 2010
(Asthma...) :
This conference report highlights selected presentations on mAb treatments for asthma, including targeting
IL-5 , IL-13, IL-9 and TNFa,
CCR3 inhibitors , histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies ... This conference report highlights selected presentations on mAb treatments for asthma, including targeting
IL-5 , IL-13, IL-9 and TNFa,
CCR3 inhibitors , histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies
Wang et al., Thorax 2013
(Asthma...) :
However,
CCR8 inhibition
had no significant effect on allergen induced BAL eosinophilia and the induction of the Th2 cytokines IL-4,
IL-5 , IL-13 and mucus levels in BAL
Tiffany et al., J Immunol 1998
:
CCR3 was expressed later and at lower levels than CCR1 and could be further
induced by
IL-5 , whereas IL-5 had little or no effect on CCR1 expression