Schramek et al., Lab Invest 2009
(Fibrosis...) :
Basal and OSM induced NRP1 mRNA expression, as well as TGF-beta1 induced NRP2 mRNA and protein expression were partially mediated by MEK1/2-ERK1/2 signaling
Lichtenberger et al., Cell 2010
(Carcinoma, Squamous Cell...) :
Mechanistically, K5-SOS upregulates VEGF, Flt1, and Neuropilin-1 in an Erk dependent manner, thereby activating an autocrine proliferation loop, whereas EGFR prevents tumor cells from apoptosis