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INS — SMAD3
Text-mined interactions from Literome
Buenemann et al., Carcinogenesis 2001
:
Of these agents, only
insulin led to a significant reduction of TGFbeta stimulated
Smad-reporter activity, suggesting that the other compounds interfere with TGFbeta induced apoptosis downstream of Smad mediated primary transcriptional responses at a level that may be constitutively altered in apoptosis-resistant hepatoma cell lines
Li et al., J Lipid Res 2008
:
Insulin or adenovirus mediated expression of constitutively active AKT1
inhibited FoxO1 and
Smad3 synergy
Watanabe et al., Biochem Biophys Res Commun 2008
:
In this study, human
insulin promoter was
activated by Smad2,
Smad3 and the pancreatic and duodenal homeobox factor-1 ( PDX-1 ) in the ALK7 pathway
Lin et al., J Biol Chem 2009
(Diabetes Mellitus, Type 2...) :
Transforming growth
factor-beta/Smad3 signaling
regulates insulin gene transcription and pancreatic islet beta-cell function ... We identify insulin as a TGF-beta target gene and show that the TGF-beta signaling effector
Smad3 occupies the insulin gene promoter and
represses insulin gene transcription ... Transduction of adenoviral Smad3 into primary human and non-human primate islets suppresses insulin content, whereas, dominant negative
Smad3 enhances
insulin levels