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HIF1A — NOS1
Text-mined interactions from Literome
Hu et al., Chin Med J (Engl) 2002
(Anoxia...) :
Hypoxia-inducible factor 1 alpha upregulates the expression of inducible
nitric oxide synthase gene in pulmonary arteries of hyposic rat
Wang et al., Bone 2004
:
Human osteoblasts were treated with or without US stimulation ( 200 micros pulse, 1 kHz at 30 mW/cm2 ) for 20 min. Cells were subjected to assessment of VEGF-A expression, NO production,
nitric oxide synthase (NOS) catalytic activities, and
HIF-1alpha transactivation ... Human osteoblasts were treated with or without US stimulation ( 200 micros pulse, 1 kHz at 30 mW/cm2 ) for 20 min. Cells were subjected to assessment of VEGF-A expression, NO production,
nitric oxide synthase (NOS) catalytic activities, and
HIF-1alpha transactivation ... Inhibition of
NOS activity by N-nitro-L-arginine methyl ester ( L-NAME ) or blockade of guanylate cyclase activity by ODQ
reduced US-augmented
HIF-1alpha transactivation and VEGF-A levels
Brennan et al., Ann R Coll Surg Engl 2005
(Carcinoma, Squamous Cell...) :
Three oral cancer cell lines were used to investigate the
effects of
NO synthase enzymes (NOS) on
HIF-1alpha expression under both normal oxygen and hypoxic conditions
Quintero et al., Cancer Res 2006
(Carcinoma, Squamous Cell...) :
Furthermore, in three human cell lines derived from human oral squamous cell carcinoma, the accumulation of
HIF-1alpha was
prevented either by inhibition of
NOS activity with the nonspecific NOS inhibitor N ( G ) -monomethyl-L-arginine or by the antioxidants N-acetyl-L-cysteine and ascorbic acid
Li et al., Circ Res 2008
(Disease Models, Animal...) :
Two weeks after ODN transfection, the
HIF-1alpha binding activities were significantly inhibited by 45 %, and high salt induced increases of
nitric oxide synthase-2 and heme oxygenase-1 transcriptions were also
inhibited by 70 % and 61 % in the renal medulla from decoy rats