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HIF1A — JUN
Pathways - manually collected, often from reviews:
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
→
Endothelin 1 (EDN1)
(transcription, activates)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
ARNT
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
p300 (EP300)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
CREB (CREB1)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
JAB1 (COPS5)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha (HIF1A)
→
c-JUN (JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha (HIF1A)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
aspartylpeptide beta-dioxygenase (ASPH)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, inhibits)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
c-JUN (JUN)
→
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
(modification, collaborate)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
→
VEGF
(transcription, activates)
-
BioCarta hypoxia-inducible factor in the cardivascular system:
HIF-1-alpha/ARNT/CREB/p300/JAB1/c-JUN complex (HIF1A-ARNT-CREB1-EP300-COPS5-JUN)
→
l-lactate dehydrogenase (LDHA)
(transcription, activates)
-
NCI Pathway Database HIF-1-alpha transcription factor network:
AP1 complex (FOS-JUN)
→
HIF1A/ARNT complex (HIF1A-ARNT)
(transcription, activates)
Yamashita et al., J Biol Chem 2001
Evidence: mutant phenotype, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Laderoute et al., Mol Cell Biol 2002
:
Exposure of these mEFs to prolonged hypoxia demonstrated an absolute requirement for N-terminal sites for
HIF-1 alpha dependent phosphorylation of
c-Jun
Ding et al., J Biol Chem 2006
(Skin Neoplasms) :
Exposure of cells to B [ a ] PDE and 5-MCDE did not
induce HIF-1alpha activation, whereas
AP-1 was significantly activated
Kim et al., Exp Cell Res 2007
(Bacterial Infections...) :
The JNK signaling and
c-Jun activation were
required to induce the
HIF-1alpha gene transcription by LPS