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CDK2 — PDGFB
Text-mined interactions from Literome
Servant et al., J Cell Biol 2000
:
However, while both factors increased the enzymatic activity of Cdk4, only
PDGF-BB stimulated
Cdk2 activity in late G ( 1 ) phase
Zhan et al., Arterioscler Thromb Vasc Biol 2002
:
Ad-DN-c-Jun attenuated PDGF-BB induced downregulation of p27 ( Kip1 ), as shown by Western blot analysis, and the prevented
PDGF-BB induced decrease in cyclin
E/cyclin dependent kinase 2 complex associated p27 ( Kip1 ), as shown by immunoprecipitation study ... Furthermore, protein kinase assay showed that Ad-DN-c-Jun blocked
PDGF-BB induced activation of
cyclin dependent kinase 2
Nathe et al., Arterioscler Thromb Vasc Biol 2002
(Arteriosclerosis) :
Consistent with this hypothesis is the finding that
CDK2 activity,
induced by
PDGF-BB , is enhanced 2.3+/-0.2-fold in the presence of IL-1beta
Kundumani-Sridharan et al., Am J Pathol 2007
(Carotid Artery Injuries) :
PDGF-BB induced cyclin D1 expression,
CDK4 activity, and Rb protein phosphorylation, leading to VSMC growth and motility, and these responses were suppressed by the blockade of STAT-5B
Xu et al., Clin Exp Pharmacol Physiol 2011
:
In addition, TSG significantly inhibited
PDGF-BB induced phosphorylation of Rb and the expression of cyclin D1, CDK4, cyclin E,
CDK2 and PCNA
Liu et al., Mol Cell Biochem 2011
:
Berberine and DHEAS decreased the expression of
CDK2 , CDK4, PCNA, cyclin D1, and cyclin E, which was
induced by
PDGF-BB
Rao et al., Biochim Biophys Acta 1999
(Hyperplasia...) :
In contrast,
PDGF-BB induced depletion of p27kip1 and increased cyclins D1 and E levels and
CDK2 and CDK4 activities