◀ Back to RAC1
ILK — RAC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2004
:
Loss of PINCH-1 or
ILK , to which alpha- and beta-parvin bind, significantly
reduced the activation of
Rac , a key signaling event that controls lamellipodium formation and cell spreading
Qian et al., Oncogene 2005
:
Overexpression of
ILK was
sufficient to induce
Rac1 activation, which was abolish by a PI3K inhibitor, indicating that Rac1 activity is involved in ILK signaling in a PI3K dependent manner
Filipenko et al., Oncogene 2005
:
In the present study, we demonstrate that
integrin linked kinase (ILK) , which is a focal adhesion protein activated by both ECM and growth factors, is
required for the activation of
Rac and Cdc42 in epithelial cells ... Taken together, these data demonstrate an essential
role of
ILK kinase activity in
Rac- and Cdc42 mediated actin cytoskeleton reorganization in epithelial cells, further solidifying a role for ILK in the regulation of cancer cell motility and invasiveness
Boulter et al., FASEB J 2006
:
Regulation of cell-matrix adhesion dynamics and
Rac-1 by
integrin linked kinase ...
ILK-GFP-F enhances cell spreading on fibronectin and
induces a constitutive increase in the levels of GTP bound
Rac-1
Vecchione et al., Hypertension 2009
:
The inhibition of
integrin linked kinase 1 by small interfering RNA
impaired Rac-1 activation and rescued oxidative stress induced vascular dysfunction in response to high pressure
Sayedyahossein et al., FASEB J 2012
:
Thus, we have identified a novel signaling pathway essential for phagocytosis in keratinocytes, which involves
ILK dependent activation of
Rac1 in response to KGF, resulting in the formation of pseudopodia and particle uptake