Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL18 ▸ IL21 ▸
TLR3 ▸ IL33 ▸ ICAM1 ▸ PTGS2 ▸ IL7 ▸ IL22 ▸ TLR9 ▸
CD40 ▸ FGB ▸ IL32 ▸ IL11 ▸ CCL2 ▸ INS ▸ IL15 ▸
IL19 ▸ IL31 ▸ JAK2 ▸ IL24 ▸ IL25 ▸ IL34 ▸ JUN ▸
IL6ST ▸ IL26 ▸ IL20 ▸ IL16 ▸ IL9 ▸ NOS2 ▸ IL37 ▸
IL27 ▸ SOCS3 ▸ TLR1 ▸ TLR7 ▸ TLR5 ▸ STAT1 ▸ TLR8 ▸
TLR10 ▸ TLR6 ▸ PTH ▸ IL12B ▸ SOAT1 ▸ SAA1 ▸ IL1RN ▸
CSRP1 ▸ AKT2 ▸ JAK1 ▸ AKT1 ▸ AKT3 ▸ FOS ▸ CD79A ▸
LEP ▸ LRPPRC ▸ IL12A ▸ VIP ▸ PIK3CA ▸ PIK3R1 ▸ RNF19A ▸
LTA ▸ CRK ▸ LEO1 ▸ PAF1 ▸ PTX3 ▸ LIF ▸ CDC73 ▸
WDR61 ▸ MMP1 ▸ ADCYAP1 ▸ CTR9 ▸ CD40LG ▸ PRKAA1 ▸ PRKAB2 ▸
PRKAG1 ▸ IL6R ▸ PRKAB1 ▸ FGF2 ▸ PRKAA2 ▸ PRKAG2 ▸ HGF ▸
PTX4 ▸ GP2 ▸ GP5 ▸ GP9 ▸ GP6 ▸ MYLIP ▸ IGF1 ▸
EDN1 ▸ MMP3 ▸ MMP9 ▸ CRH ▸ TCF3 ▸ MMP2 ▸ GRAP2 ▸
JAK3 ▸ TCF19 ▸ CISH ▸ TCF24 ▸ TCF20 ▸ TCF23 ▸ TCF25 ▸
TCF4 ▸ TCF15 ▸ TCF21 ▸ TCF12 ▸ CD4 ▸ TCF7 ▸ MYD88 ▸
IFNB1 ▸ TGFB3 ▸ MMP13 ▸ CA2 ▸ NOS3 ▸ PLG ▸ MCL1 ▸
TGFB2 ▸ A2M ▸ OSM ▸ AHSA1 ▸ PAM ▸ TIMP1 ▸ NOS1 ▸
HP ▸ CD14 ▸ HMGB1 ▸ HNRNPF ▸ CEBPB ▸ HNRNPH1 ▸ PTBP2 ▸
PGF ▸ CD46 ▸ PTBP1 ▸ NOX4 ▸ CASP3 ▸ NA ▸ AR ▸
APOB ▸ ALB ▸ NFKBIA ▸ MT3 ▸ CSF1 ▸ STAT5A ▸ S100A12 ▸
PRG4 ▸ PI3 ▸ TAT ▸ PRG2 ▸ TNFSF11 ▸ PRG3 ▸ NOX3 ▸
PRKACG ▸ NGF ▸ CASP5 ▸ NOX5 ▸ CASP10 ▸ CASP6 ▸ PRKAR1B ▸
CASP16 ▸ PRKAR2B ▸ PRKAR2A ▸ CASP12 ▸ CASP7 ▸ CASP9 ▸ NOX1 ▸
PRKAR1A ▸ CASP1 ▸ CASP2 ▸ CASP14 ▸ CASP8 ▸ PRKACB ▸ CASP4 ▸
CSF3 ▸ PRL ▸ SOCS1 ▸ PDGFB ▸ FAS ▸ VCAM1 ▸ POLDIP2 ▸
ANGPT2 ▸ MT4 ▸ FOXP3 ▸ GPI ▸ LPA ▸ ITIH4 ▸ SOD3 ▸
SPP1 ▸ MMP11 ▸ CD8A ▸ SOD1 ▸ SELE ▸ SAA2 ▸ MMP7 ▸
MMP14 ▸ CALM3 ▸ CYP19A1 ▸ MMP10 ▸ FASLG ▸ SYT1 ▸ IFI44 ▸
TNFRSF11B ▸ PTPN11 ▸ HMOX1 ▸ IRF1 ▸ MMP8 ▸ APP ▸ IKBKB ▸
MMP12 ▸ SOD2 ▸ BCL2 ▸ CEBPA ▸ PLA2G1B ▸ ANG ▸ NUP43 ▸
LBP ▸ CPOX ▸ F2RL1 ▸ NAALADL1 ▸ MMP17 ▸ MMP20 ▸ CTSB ▸
SERPINE1 ▸ MMP19 ▸ MMP24 ▸ MMP27 ▸ MMP25 ▸ MMP21 ▸ CALML3 ▸
EGF ▸ HDAC1 ▸ MMP26 ▸ CCL3 ▸ MMP15 ▸ LPL ▸ FCER2 ▸
CD28 ▸ MMP28 ▸ MMP16 ▸ ADIPOQ ▸ SETBP1 ▸ ALG1 ▸ FGF4 ▸
BCL3 ▸ MAP3K7 ▸ PTPRC ▸ IRAK4 ▸ FGF23 ▸ PRDX2 ▸ GFAP ▸
AGT ▸ BCL6 ▸ SAA4 ▸ MIF ▸ PPARG ▸ SERPINA3 ▸ TYR ▸
NPS ▸ LTF ▸ PTHLH ▸ AGTR2 ▸ HDAC2 ▸ HES1 ▸ FGF7 ▸
APC ▸ PLA2G4A ▸ GH1 ▸ CSK ▸ ERVK-6 ▸ MSH3 ▸ MSH6 ▸
FGF1 ▸ IL23A ▸ TP53 ▸ CREB3 ▸ CHUK ▸ FGF19 ▸ MSH4 ▸
CREB1 ▸ FGF5 ▸ IL2RA ▸ FGF3 ▸ FGF11 ▸ IGF2 ▸ FGF8 ▸
IFNA2 ▸ ABCC1 ▸ FGF6 ▸ MTX1 ▸ FGF14 ▸ PPARA ▸ LTB ▸
CUL1 ▸ FGF10 ▸ CEACAM5 ▸ FGF17 ▸ FGF12 ▸ MSH5 ▸ KITLG ▸
FGF16 ▸ FGF9 ▸ PDLIM7 ▸ F2R ▸ FGF18 ▸ IL1R1 ▸ CREB5 ▸
FGF20 ▸ FGF22 ▸ FGF13 ▸ SKP1 ▸ FGF21 ▸ SMAD3 ▸ MSH2 ▸
IFNA10 ▸ HES3 ▸ CEBPD ▸ HES6 ▸ ANXA1 ▸ BMP2 ▸ EGFR ▸
CD8B ▸ IFNA13 ▸ UCN ▸ HES5 ▸ IFNA17 ▸ HSPD1 ▸ PTK7 ▸
IFNA16 ▸ CD44 ▸ PTK2 ▸ IFNA5 ▸ TXN ▸ CDKN1A ▸ SST ▸
EPO ▸ ESR1 ▸ TRAF6 ▸ CCL5 ▸ MAP2K1 ▸ MTOR ▸ IFNA4 ▸
IFNA1 ▸ CXCL12 ▸ IFNA6 ▸ RHO ▸ SMAD2 ▸ IFNA8 ▸ HES2 ▸
MRXS5 ▸ HES4 ▸ IFNA7 ▸ HES7 ▸ PTK6 ▸ IFNA14 ▸ IFNA21 ▸
MPO ▸ CXCL1 ▸ AVP ▸ PRKCA ▸ MUC1 ▸ C4BPA ▸ ANPEP ▸
CAV2 ▸ TFPI ▸ CAV1 ▸ WNK1 ▸ PAEP ▸ FCGR1A ▸ BAX ▸
NAMPT ▸ RBBP4 ▸ P2RX7 ▸ MAP2K4 ▸ IKBKG ▸ HSPB1 ▸ SMAD4 ▸
HAMP ▸ NPY ▸ KLK3 ▸ STAT4 ▸ RENBP ▸ CAV3 ▸ IDO1 ▸
RBBP7 ▸ CNTN2 ▸ CNTF ▸ CXCL10 ▸ SP1 ▸ SMAD7 ▸ TAB1 ▸
ADCY8 ▸ CD5 ▸ TNFRSF1B ▸ MBP ▸ BMP7 ▸ HDC ▸ SAP30 ▸
ADCY2 ▸ REL ▸ TGFA ▸ STS ▸ SYK ▸ SUDS3 ▸ SMAD9 ▸
NPEPPS ▸ MET ▸ SMAD6 ▸ SMAD1 ▸ NOD1 ▸ BMP6 ▸ CCR5 ▸
NOD2 ▸ PDCD11 ▸ IFI27 ▸ HLA-DRB1 ▸ ARID4B ▸ ADCY10 ▸ SAP130 ▸
NM ▸ NPPA ▸ SMAD5 ▸ WNT5A ▸ GZMB ▸ TNFRSF1A ▸ HIF1A ▸
CORT ▸ CLEC7A ▸ GCG ▸ SELP ▸ IRS1 ▸ SHC1 ▸ CHAT ▸
RAG2 ▸ CSE ▸ DUSP1 ▸ ADCY9 ▸ IRAK1 ▸ S100B ▸ ADM ▸
ADCY4 ▸ IRF3 ▸ BCL10 ▸ GIF ▸ IL17RA ▸ SIN3A ▸ ADCY5 ▸
JUND ▸ ACE ▸ MUC4 ▸ CYP3A4 ▸ ACP2 ▸ DDIT3 ▸ ADCY7 ▸
SELL ▸ ADCY1 ▸ ADCY3 ▸ ADCY6 ▸ SRC ▸ HLA-DRA ▸ CAT ▸
AGTR1 ▸ RAG1 ▸ CD86 ▸ IBD6 ▸ UTP15 ▸ IBD5 ▸ REG1A ▸
MAP2K7 ▸ HRAS ▸ ST2 ▸ HMGCR ▸ NLRP3 ▸ IBD8 ▸ PLD1 ▸
IRAK3 ▸ IBD4 ▸ S100A9 ▸ ICAM5 ▸ UTP3 ▸ ATF3 ▸ ADORA1 ▸
BTRC ▸ PTGS1 ▸ IBD7 ▸ MUC8 ▸ MUC20 ▸ UTP20 ▸ ICOSLG ▸
EIF2AK2 ▸ CCL20 ▸ PIGA ▸ MUC16 ▸ ANXA6 ▸ IBD2 ▸ BMP1 ▸
IL17F ▸ TNFSF13B ▸ MUC12 ▸ PTPN4 ▸ APOE ▸ PDGFA ▸ CYP1A1 ▸
BCL9 ▸ TNFRSF8 ▸ HSP90AB1 ▸ MOG ▸ IBD9 ▸ IGFBP1 ▸ INA ▸
SFTPC ▸ ATP8A2 ▸ CCND1 ▸ MUC19 ▸ MUC2 ▸ PGP ▸ MUC17 ▸
HSF1 ▸ ICAM3 ▸ EDN3 ▸ ARSA ▸ MUC13 ▸ GRB2 ▸ MUC6 ▸
ITGB1 ▸ SEA ▸ TF ▸ MUC21 ▸ IL17D ▸ TPO ▸ ABCB1 ▸
FGFR3 ▸ VAV1 ▸ IBD3 ▸ POMC ▸ SETD2 ▸ IRF4 ▸ CTF1 ▸
CXCL17 ▸ ZFP36 ▸ CYP3A ▸ MPG ▸ NCAM1 ▸ PPP2CA ▸ MAP2K6 ▸
MAP2K3 ▸ S100A8 ▸ CTSL ▸ BCL5 ▸ MUC22 ▸ EDN2 ▸ MUC15 ▸
MAP2K5 ▸ HSPG2 ▸ MUC7 ▸ LGALS1 ▸ UTP18 ▸ UTP23 ▸ PLD2 ▸
AHR ▸ UTP6 ▸ CTGF ▸ ICAM4 ▸ OPRM1 ▸ MAP2K2 ▸ ICAM2 ▸
CR2 ▸ RETN ▸ TYK2 ▸ CPB1 ▸ ABL1 ▸ CRYGEP ▸ CD163 ▸
GPX2 ▸ PGD ▸ BMP5 ▸ BCR ▸ IL1R2 ▸ PARP12 ▸ NEUROD1 ▸
OAS2 ▸ PARP3 ▸ CYP1A2 ▸ LCN2 ▸ PARP16 ▸ SCARB1 ▸ MAF ▸
SERPINF1 ▸ PARP1 ▸ ITGAM ▸ PARP15 ▸ GPX8 ▸ NEUROD4 ▸ UCN2 ▸
GNRH1 ▸ SLPI ▸ RPL17 ▸ C1orf228 ▸ TNPO1 ▸ OPN1LW ▸ XBP1 ▸
GPX1 ▸ GPX7 ▸ ATP7A ▸ HSPA5 ▸ C1QA ▸ PIM1 ▸ PARK2 ▸
BGLAP ▸ HPD ▸ WNT10B ▸ HDAC6 ▸ BMP3 ▸ ETS1 ▸ CPB2 ▸
MS4A1 ▸ PLD5 ▸ GTF2B ▸ FUT4 ▸ HSP90AA1 ▸ MAPKAPK2 ▸ HCL1 ▸
GPX5 ▸ PARP4 ▸ GPX6 ▸ EPS8 ▸ BMP4 ▸ PTS ▸ PLD4 ▸
TSLP ▸ EPX ▸ ACHE ▸ EBP ▸ CTSS ▸ CCL1 ▸ WNT4 ▸
PPP2R2B ▸ PLD6 ▸ EPS15 ▸ PARP2 ▸ IRF9 ▸ OAS3 ▸ CLU ▸
XRCC1 ▸ GNA13 ▸ CIB1 ▸ PLD3 ▸ BPI ▸ CHGA ▸ ADORA3 ▸
ANGPT1 ▸ C1QB ▸ DNMT1 ▸ NEUROD2 ▸ NTF3 ▸ TRNAI1 ▸ PON1 ▸
C5AR1 ▸ BMP15 ▸ PDCD4 ▸ GYS1 ▸ ATP5O ▸ CD80 ▸ IGFBP3 ▸
FOXO3 ▸ FXR1 ▸ ETS2 ▸ NEUROD6 ▸ BMP10 ▸ PARP6 ▸ PARP8 ▸
TRPV1 ▸ NDP ▸ FXYD1 ▸ PARP9 ▸ PITX2 ▸ GPX4 ▸ LYN ▸
OAS1 ▸ IDS ▸ CA1 ▸ CD19 ▸ AHSG ▸ NFATC2 ▸ KNG1 ▸
PARP11 ▸ THBD ▸ GYS2 ▸ HCL2 ▸ FXR2 ▸ PPP2R1A ▸ PARP14 ▸
PCK1 ▸ NNMT ▸ BTK ▸ MPL ▸ GAL ▸ CSH2 ▸ GHRH ▸
IRF5 ▸ PARP10 ▸ ESR2 ▸ CD2 ▸ TRAF2 ▸ CXCR4 ▸ HSPB3 ▸
ROR1 ▸ TIMP2 ▸ CXCL6 ▸ IRF8 ▸ HCK ▸ HCL3 ▸ CX3CR1 ▸
GPX3 ▸ CD1D ▸ TEC ▸ HDAC3 ▸ TGM2 ▸ TAC1 ▸ XIAP ▸
CHP2 ▸ CXCL14 ▸ ADIPOR1 ▸ TRAF3IP2 ▸ SLC33A1 ▸ QRICH2 ▸ EDNRA ▸
LGALS3 ▸ ABCG2 ▸ CALM2 ▸ EGR1 ▸ RNASE3 ▸ TTR ▸ BAI1 ▸
COQ4 ▸ TAC3 ▸ RAB7B ▸ EEF1A2 ▸ MYO16 ▸ CDKN2A ▸ RLN1 ▸
MTA3 ▸ CALCA ▸ FYN ▸ COL1A1 ▸ SPN ▸ TFAP2A ▸ GSTM3 ▸
MYO19 ▸ CPA1 ▸ PSMB9 ▸ KRT13 ▸ CCK ▸ COQ5 ▸ COQ2 ▸
CRAT ▸ TSN ▸ WNT3 ▸ NMU ▸ MYO6 ▸ RASIP1 ▸ PTPN22 ▸
ABCA4 ▸ IFIT1 ▸ ADH5 ▸ P2RX1 ▸ IGF1R ▸ TGM4 ▸ HDAC9 ▸
TRAF5 ▸ CDH1 ▸ BSG ▸ WNT16 ▸ TBCC ▸ CXCL9 ▸ SMN1 ▸
SFTPA1 ▸ CNR2 ▸ CD274 ▸ TAC4 ▸ APOA4 ▸ SCG3 ▸ TRAF1 ▸
LCAT ▸ MAL ▸ KDR ▸ CALM1 ▸ ACSM3 ▸ STK31 ▸ MAP3K3 ▸
STK33 ▸ RAF1 ▸ OXTR ▸ BLVRB ▸ AMELX ▸ SMC2 ▸ QRICH1 ▸
GCLC ▸ GSTM2 ▸ STK25 ▸ FLT3LG ▸ CD69 ▸ ECM1 ▸ HDAC10 ▸
SCG2 ▸ TGM7 ▸ STEAP4 ▸ PDCD1 ▸ TNFSF10 ▸ IRAK2 ▸ CCR6 ▸
C3AR1 ▸ THBS1 ▸ TNFAIP6 ▸ REN ▸ SARS ▸ CD33 ▸ ECM2 ▸
WNT6 ▸ HDAC11 ▸ PC ▸ RORC ▸ SERPINA1 ▸ JUNB ▸ KRT10 ▸
E2F1 ▸ TBP ▸ AD5 ▸ STK39 ▸ ADH7 ▸ MCC ▸ COQ7 ▸
CEACAM1 ▸ STK24 ▸ LYZ ▸ HDAC5 ▸ PDCD5 ▸ NPY4R ▸ IGFBP2 ▸
AZU1 ▸ STK11 ▸ CXCL16 ▸ SDC1 ▸ ACE2 ▸ CXCL13 ▸ SMC5 ▸
MSC ▸ IL2RG ▸ RUNX2 ▸ HPX ▸ CXCL5 ▸ PPP5C ▸ APCS ▸
GSTM4 ▸ AREG ▸ RLN3 ▸ KRT37 ▸ IGFBP7 ▸ TSC22D3 ▸ PDAP1 ▸
BDNF ▸ WAS ▸ MIP ▸ TNC ▸ CD38 ▸ CP ▸ ITGA5 ▸
LRG1 ▸ STK19 ▸ CD59 ▸ CXCR3 ▸ BAI3 ▸ COQ9 ▸ TRD ▸
PINK1 ▸ IRF7 ▸ LDLR ▸ COQ6 ▸ PCK2 ▸ SMC3 ▸ MEPE ▸
SCG5 ▸ POU5F1 ▸ CD1C ▸ UCN3 ▸ WNT1 ▸ C5 ▸ PTK2B ▸
WNT2 ▸ HBD ▸ GIP ▸ CCR1 ▸ TIRAP ▸ CXCL3 ▸ VIMP ▸
NTN1 ▸ ANGPT4 ▸ OXA1L ▸ MTA2 ▸ VHLL ▸ KRT38 ▸ ADAM17 ▸
STK40 ▸ SERPINB5 ▸ HDAC8 ▸ STK16 ▸ FMR1 ▸ ATF4 ▸ KLRB1 ▸
HCFC1 ▸ STK3 ▸ RLN2 ▸ GSTM1 ▸ ACR ▸ STK36 ▸ RABEPK ▸
ARG2 ▸ IL1RAP ▸ ATF1 ▸ NOTCH2 ▸ PRNP ▸ STK35 ▸ ARG1 ▸
NR4A1 ▸ STK38 ▸ PDCD2 ▸ COQ3 ▸ MUC5AC ▸ DERL1 ▸ GAST ▸
ACAN ▸ WNT11 ▸ SLC39A14 ▸ TIMP3 ▸ NANOG ▸ STK4 ▸ CD34 ▸
NTF4 ▸ MCS ▸ VCP ▸ SOS1 ▸ SLC25A3 ▸ MYC ▸ IRG1 ▸
RAC1 ▸ CREBBP ▸ MICE ▸ IGFBP5 ▸ CXCL2 ▸ ITGA4 ▸ PDCD6 ▸
HSPB8 ▸ HDAC7 ▸ CDKN1B ▸ VWF ▸ PHB ▸ PIAS3 ▸ SERPING1 ▸
ADH6 ▸ RPS6KA3 ▸ CHP1 ▸ IRF2 ▸ DYNLRB1 ▸ MTA1 ▸ IGFBP4 ▸
SMC4 ▸ ADH4 ▸ CDK4 ▸ AIF1 ▸ GAS6 ▸ SERPINA6 ▸ HDAC4 ▸
PDCD10 ▸ NR0B1 ▸ NOTCH1 ▸ PDCD7 ▸ STK10 ▸ CDK9 ▸ EREG ▸
FGFR2 ▸ SAA3P ▸ PARK7 ▸ ICOS ▸ RAB7A ▸ ASIP ▸ CXCL11 ▸
NLRC5 ▸ CX3CL1 ▸ ACD ▸ ROR2 ▸ BAI2 ▸ RB1 ▸ CCL4 ▸
MYO10 ▸ CEBPZ ▸ PLAT ▸ RBP4 ▸ NT5E ▸ NTS ▸ SERPINE2 ▸
MKL1 ▸ GSTM5 ▸ IL2RB ▸ SMC6 ▸ SP3 ▸ DEFB114 ▸ MIA ▸
FLOT2 ▸ P2RY6 ▸ CCR2 ▸ FGL1 ▸ PLA2G2D ▸ ITGA2B ▸ DEFB4B ▸
GCSAM ▸ CBL ▸ ZBTB16 ▸ FOXO1 ▸ HNRNPA1 ▸ PTPRE ▸ PTGER4 ▸
F12 ▸ PIK3C3 ▸ PIAS1 ▸ ERBB3 ▸ MEOX2 ▸ PRKD1 ▸ SH3GL2 ▸
NFKB2 ▸ KAT2B ▸
Data information
Please see the Gene Interactions Track Manual.