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Text-mined interactions from Literome

Cowdery et al., J Immunol 1999 : Although LPS alone is a poor inducer of p40 transcription, both LPS and CpG DNA induce similar nuclear translocation of NF-kappaB
Zhang et al., Cell Immunol 2000 : NF-kappa B regulates the LPS induced expression of interleukin 12 p40 in murine peritoneal macrophages : roles of PKC, PKA, ERK, p38 MAPK, and proteasome
Wilkin et al., Eur J Immunol 2002 : We observed that ATPgammaS potentiated the IL-12p40 release induced by TNF-alpha, but also by lipopolysaccharides (LPS) and soluble CD40 ligand ( sCD40L )
Goodridge et al., Immunology 2003 (MAP Kinase Signaling System) : We now define distinct signalling mechanisms that regulate lipopolysaccharide (LPS) mediated induction of IL-12 p40 and p35 in macrophages and which may therefore provide therapeutic targets for precise and specific fine tuning of cytokine responses
Utsugi et al., J Immunol 2003 (MAP Kinase Signaling System) : Conversely, inhibition of JNK activation using SP600125 dose dependently enhanced both LPS induced IL-12 p40 production from THP-1 cells and p70 production from human monocytes
Martin et al., J Immunol 2003 (MAP Kinase Signaling System) : In the present study, the role of the phosphatidylinositol 3 kinase (PI3K)-Akt pathway in regulating P. gingivalis LPS induced production of IL-10, IL-12 p40 , and IL-12 p70 by human monocytes was investigated
Ma et al., J Immunol 2004 : A role for c-Jun N-terminal kinase (JNK) MAPK in LPS induced IL-12p40 regulation in a promonocytic THP-1/CD14 cell line was demonstrated by using specific inhibitors of JNK activation, SP600125 and a dominant negative stress activated protein/extracellular signal regulated kinase kinase-1 mutant
Hoentjen et al., Blood 2005 : In this study, we investigated the role of nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription 3 ( STAT3 ) in lipopolysaccharide (LPS) induced IL-12p40 gene expression in bone marrow derived-dendritic cells ( BMDCs ) isolated from wild-type ( WT ) and IL-10 ( -/- ) mice ... Chromatin immunoprecipitation demonstrated enhanced NF-kappaB ( cRel, RelA ) binding to the IL-12p40 promoter in IL-10 ( -/- ) but not WT BMDCs. Interestingly, LPS induced STAT3 phosphorylation in WT but not IL-10 ( -/- ) BMDCs, a process blocked by IL-10 receptor blocking antibody
Chambers et al., Clin Exp Immunol 2004 (HIV Infections) : HIV infection of THP-1 myeloid cells resulted in decreased LPS induced nuclear factor binding to the NF-kappaB, AP-1, and Sp1 sites of the IL-12 p40 promoter
Ichikawa et al., Biol Pharm Bull 2004 : These results suggest that gallate containing catechins, particularly EGCG, inhibits LPS induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation
Obata et al., Scand J Immunol 2006 : This was confirmed by mRNA analysis, which showed that H ( 2 ) O ( 2 ) increased LPS induced mRNA expression of both IL-12p40 and IL-12p35 subunits with an increased p40/p35 ratio
Mohammad et al., Int Immunol 2006 (Diabetes Mellitus, Experimental) : Dysregulation of TLR4 expression in the diabetic state correlated with increased nuclear factor kappa B (NF-kappaB) activation in response to the TLR4 ligand LPS and higher expression of IL-12p40 , tumor necrosis factor alpha (TNFalpha), IL-6 and inducible nitric oxide synthase but lowered expression of IL-10
Wang et al., J Clin Immunol 2007 : In contrast, the addition of atRA inhibited the LPS induced TNF-alpha and IL-12p40 mRNA expression, and the number of ELISPOT positive cells for TNF-alpha
Goyarts et al., Exp Dermatol 2008 : NE inhibited the lipopolysaccharide (LPS) stimulated production of interleukin (IL)-23, IL-12 p40 , tumor necrosis factor (TNF)-alpha and IL-6 whereas the expression of IL-10 was not significantly affected
Ma et al., J Biol Chem 2009 (Acquired Immunodeficiency Syndrome) : We have previously shown that lipopolysaccharide (LPS) induced IL-12p40 production in monocytic cells is regulated by NFkappaB and AP-1 transcription factors through the activation of two distinct upstream signaling pathways, namely the c-Jun-N-terminal kinase (JNK) and the calmodulin dependent protein kinase-II activated pathways
Tierney et al., Immunol Cell Biol 2009 (Encephalomyelitis, Autoimmune, Experimental) : Our results show that lower doses of interferon-gamma (IFN-gamma) were more effective at priming bone marrow derived macrophages ( BMMphi ) to produce more interleukin 10 (IL-10) and less IL-12p40 in response to lipopolysaccharide (LPS) and immune complexes compared with LPS alone
Avni et al., Immunol Lett 2009 (Inflammation) : In this study we thus investigated the effect of PCERA-1 on LPS induced release of TNFalpha, interleukin (IL)-10 and IL-12p40 , in vivo, and ex vivo
Boucher et al., Viral Immunol 2010 (HIV Infections...) : In monocytes, mutations in the NF-kappaB, AP-1, Sp1, or Ets-2 binding sites resulted in complete inhibition of LPS stimulated IL-12p40 promoter activity using a luciferase based assay
Kasai et al., J Med Invest 2011 (Bone Diseases, Metabolic) : In ex vivo cultures, raloxifene therapy inhibited LPS stimulated production of IL-1ß, IL-6, IL-12p40 , IL-12p70 and TNF-a, but not PHA stimulated production of IL-4 and IFN-?
Mora et al., Cell cycle (Georgetown, Tex.) 2012 : Bindarit inhibits the LPS induced MCP-1 and IL-12ß/p40 expression without affecting other analyzed cytokines
Rossato et al., Proc Natl Acad Sci U S A 2012 (Sepsis) : Conversely, the production of LPS induced TNF-a, IL-6, and IL-12p40 is increased significantly when miR-187 expression is silenced
Ma et al., J Exp Med 1996 : The priming effect of IFN-gamma on the LPS induced p40 gene transcription requires preincubation of the cells with IFN-gamma for at least 8 h to obtain a maximal effect
Trepicchio et al., J Immunol 1996 (Inflammation) : rhIL-11 pretreatment of thioglycollate elicited peritoneal macrophages resulted in greater than 60 % inhibition of LPS induced production of TNF-alpha, IL-1beta, IL-12 p40 , and nitric oxide
Salkowski et al., Infect Immun 1997 : We compared the ability of LPS and MPL to induce interleukin-10 (IL-10), IL-12 p35, IL-12 p40 , gamma interferon ( IFN-gamma ), glucocorticoid receptor ( GR ), IL-1 receptor antagonist (IL-1ra), and inducible nitric oxide synthase mRNA expression in murine peritoneal macrophages
Aloisi et al., J Immunol 1997 : LPS induces secretion of IL-12 p40 , but not of IL-12 p75, as detected by specific ELISA