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IRF6 — NGF

Text-mined interactions from Literome

Xiong et al., Mol Pharmacol 1999 : The results showed that LPS alone induced NGF release and moderate NO production ... However, costimulation with LPS plus IFNgamma greatly enhanced NO production but significantly suppressed LPS induced NGF release ... Quantitative reverse transcription-polymerase chain reaction demonstrated S-nitroso-N-acetyl-DL-penicillamine was also able to inhibit the LPS induced NGF mRNA expression
Barouch et al., J Neuroimmunol 2000 : Thus, LPS increased the expression of NGF , BDNF and NT-3 in splenocytes and B cells, whereas Con-A increased the mRNA of NT-3 and NT-4 in T cells and NGF expression in splenocytes
Bjorling et al., BJU Int 2001 : LPS stimulated a significant increase in bladder NGF 90 min after instillation, but bladder NGF content was significantly less than that in bladders of control mice 3 and 7 h after LPS instillation
Nakajima et al., J Neurosci Res 2001 : Stimulation of the cells with lipopolysaccharide (LPS) increased BDNF secretion, and induced NGF secretion
Peeraully et al., Am J Physiol Endocrinol Metab 2004 : In contrast, LPS increased NGF mRNA levels and NGF secretion
Rost et al., Regul Pept 2005 (Asthma) : Cell stimulation with LPS leads to release of NGF and NT3
Hennigan et al., Brain Res 2007 (Synaptic Transmission) : In addition, LPS blocks plasticity associated changes in nerve growth factor expression, TrkA activation and extracellular signal regulated kinase activation
Jiang et al., J Immunol 2007 : In the present study, we demonstrate that there were weak expressions of NGF and no expression of NGF receptors p140(TrkA) and p75 ( NTR ) on human immature MoDCs, however, the expression of NGF and p75 ( NTR ) on MoDCs could be significantly up-regulated by LPS in a dose- and time dependent manner
Jiang et al., Mol Immunol 2008 : In this study, we demonstrated that stimulation with TLR ligand lipopolysaccharide (LPS) , but not lipoteichoic acid (LTA), Poly ( I:C ) and CpG oligodeoxynucleotide ( ODN ), could significantly induce expression of NGF and NGF receptor p75(NTR) on mouse bone marrow derived DCs ( BMDCs ) in vitro in dose- and time dependent manners ... However, there was no such effect on DCs derived from TLR4-deficient mice, indicating the LPS induced upregulation of NGF and p75 ( NTR ) was TLR4 pathway dependent ... Furthermore, LPS induced upregulation of NGF and p75 ( NTR ) could be inhibited by p38MAPK inhibitor SB203580 and NF-kappaB inhibitor PDTC, suggesting TLR4 triggered activation of p38MAPK and NF-kappaB pathways are responsible for the process
Noga et al., Clin Exp Allergy 2008 (Hypersensitivity) : Selective induction of nerve growth factor and brain derived neurotrophic factor by LPS and allergen in dendritic cells