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CCNA2 — CDKN1A

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: CDKN1A → Complex of CCNA1-CCNA2-CDK2 (protein-protein, inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: CCNA2 — CDKN1A (coimmunoprecipitation) Rohaly et al., Cell 2005*
• IRef Bind_translation Interaction: CCNA2 — CDKN1A (coimmunoprecipitation) Poon et al., J Biol Chem 1996
• IRef Bind_translation Interaction: CCNA2 — CDKN1A (coimmunoprecipitation) Orend et al., Oncogene 1998
• IRef Biogrid Interaction: CCNA2 — CDKN1A (physical association, affinity chromatography technology) Lin et al., J Cell Biochem 2011*
• IRef Biogrid Interaction: CCNA2 — CDKN1A (physical association, affinity chromatography technology) Levkau et al., Mol Cell 1998*
• IRef Biogrid Interaction: CCNA2 — CDKN1A (direct interaction, pull down) Chen et al., Mol Cell Biol 1996
• IRef Biogrid Interaction: CCNA2 — CDKN1A (physical association, affinity chromatography technology) Joaquin et al., J Biol Chem 2003*
• IRef Biogrid Interaction: CCNA2 — CDKN1A (physical association, affinity chromatography technology) Wu et al., Oncogene 1997*
• IRef Biogrid Interaction: CCNA2 — CDKN1A (physical association, affinity chromatography technology) Amador et al., Mol Cell 2007*
• IRef Biogrid Interaction: CCNA2 — CDKN1A (physical association, affinity chromatography technology) Poon et al., J Biol Chem 1996
• IRef Dip Interaction: CDKN1A — CCNA2 (physical association, coimmunoprecipitation) Harper et al., Cell 1993*
• IRef Hprd Interaction: CCNA2 — CDKN1A (in vivo) Poon et al., J Biol Chem 1996, Orend et al., Oncogene 1998
• IRef Hprd Interaction: CCNA2 — CDKN1A (in vitro) Poon et al., J Biol Chem 1996, Orend et al., Oncogene 1998
• IRef Intact Interaction: Complex of CDKN1A-CDK2-CCNA2 (physical association, surface plasmon resonance) Lacy et al., J Mol Biol 2005*
• IRef Intact Interaction: CDKN1A — CCNA2 (physical association, surface plasmon resonance) Lacy et al., J Mol Biol 2005*
• IRef Intact Interaction: Complex of PKMYT1-CKS2-CCNB2-CKS1B-CCNA2-CDK1-CCNB1-CDKN1B-CDKN1A (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 18 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Intact Interaction: Complex of 27 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Varjosalo et al., Cell reports 2013
• IRef Ophid Interaction: CDKN1A — CCNA2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Li et al., J Biol Chem 2002 : p21 binds to and inhibits both the DNA synthesis regulator proliferating cell nuclear antigen and cyclin A/E-CDK2 complexes
Shen et al., Cancer Res 2008 (Neoplasms...) : p53-p21 pathway activation was required for the depletion of Cyclin B1, Cyclin A , and CDC2 in Nutlin-3a treated cells and for endoreduplication after Nutlin-3a removal
Chae et al., BMB Rep 2011 : Furthermore, expression of Cyclin A increases NF-Y 's affinity for CCAAT sequences in the CDC2 promoter ; however, Cyclin A 's induction of CDC2 transcription is antagonized by p21 , an inhibitor of CDK2/Cyclin A
Blain et al., J Biol Chem 1997 : In contrast to their differential interaction, cyclin A-Cdk2 and cyclin D2-Cdk4 were similarly inhibited by bound p21 ( Cip1/Waf1 )