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STAT3 — ZFP36
Text-mined interactions from Literome
Schaljo et al., J Immunol 2009
(Inflammation) :
We found that IL-10 initiates a
Stat3 dependent increase of
TTP expression accompanied by a delayed decrease of p38 MAPK activity
Joe et al., J Biol Chem 2011
(Inflammation) :
Nicotine induced activation of
STAT3 enhanced STAT3 binding to the TTP promoter,
increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS stimulated TNF-a production
Gaba et al., J Immunol 2012
:
Correspondingly,
STAT3 was
required for efficient IL-10 induced
TTP expression ... Hence, by
inducing TTP expression,
STAT3 activates a negative regulatory loop that controls the IL-10/STAT3 anti-inflammatory response