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AKT1 — VIM

Pathways - manually collected, often from reviews:

• NCI Pathway Database Caspase Cascade in Apoptosis: Vimentin (VIM) → AKT1 (AKT1) (modification, collaborate) Byun et al., Cell Death Differ 2001*, Zhu et al., Oncogene 2011
  Evidence: assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: AKT1 (AKT1) → Vimentin fragment 4 (VIM) (modification, inhibits) Byun et al., Cell Death Differ 2001*, Zhu et al., Oncogene 2011
  Evidence: assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: AKT1 (AKT1) → Vimentin fragment 3 (VIM) (modification, inhibits) Byun et al., Cell Death Differ 2001*, Zhu et al., Oncogene 2011
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AKT1 — VIM (physical association, affinity chromatography technology) Zhu et al., Oncogene 2011
• IRef Biogrid Interaction: AKT1 — VIM (direct interaction, pull down) Zhu et al., Oncogene 2011
• IRef Biogrid Interaction: AKT1 — VIM (direct interaction, enzymatic study) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (colocalization, cosedimentation in solution) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (physical association, bimolecular fluorescence complementation) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (physical association, anti bait coimmunoprecipitation) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (direct interaction, pull down) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (physical association, pull down) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (phosphorylation reaction, protein kinase assay) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (colocalization, fluorescence microscopy) Zhu et al., Oncogene 2011
• IRef Intact Interaction: AKT1 — VIM (physical association, anti tag coimmunoprecipitation) Zhu et al., Oncogene 2011
• IRef Intact Interaction: Complex of DDX5-VIM-HSPA9-AKT1 (association, anti bait coimmunoprecipitation) Zhu et al., Oncogene 2011
• IRef Intact Interaction: Complex of TPM2-ACTB-TPM4-TUBB4B-TRHDE-AKT1-HSPA9-DDX5-VIM (association, anti bait coimmunoprecipitation) Zhu et al., Oncogene 2011

Text-mined interactions from Literome

Strizzi et al., J Cell Sci 2005 (Mammary Neoplasms, Animal) : Treating EpH4/Cripto-1 or HC-11/Cripto-1 mammary cells with exogenous soluble Netrin-1 resulted in increased expression of E-cadherin and UNC5H1, decreased expression of vimentin and decreased activation of Akt as determined by western blotting
Zhu et al., Oncogene 2011 (Neoplasm Invasiveness...) : The binding of AKT ( tail region ) to Vim ( head region ) results in Vim Ser39 phosphorylation enhancing the ability of Vim to induce motility and invasion while protecting Vim from caspase induced proteolysis
Lian et al., J Biol Chem 2012 : Furthermore, inhibition of PI3K/Akt/mTOR signaling, but not canonical Smad signaling, downstream of TGFß, blocked TGFß induced synthesis of vimentin , and inhibited ATF4 dependent Ocn transcription in osteoblasts