Gene interactions and pathways from curated databases and text-mining

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CHUK — VEGFA

Text-mined interactions from Literome

Dikov et al., Cancer Res 2001 : However, although TNF-alpha induced rapid activation of IkappaB kinase (IKK) as expected, this activity was substantially reduced in the presence of VEGF
Kiriakidis et al., J Cell Sci 2003 (Inflammation...) : VEGF expression in human macrophages is NF-kappaB dependent : studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
Maeng et al., Cell Signal 2006 : Using two PKC inhibitors has demonstrated that VEGF concomitantly stimulates IKK and its negative regulatory signal ERK through PKC that lies downstream of KDR/Flk-1
Tong et al., Respir Res 2006 : In addition, HIMF strongly induced Akt phosphorylation, and suppression of Akt activation by specific inhibitors and dominant negative mutants for PI-3K, and IKK or IkappaBalpha blocked HIMF induced NF-kappaB activation and attenuated HIMF induced VEGF production