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CASP7 — UPK3B
Text-mined interactions from Literome
Igaki et al., Proc Natl Acad Sci U S A 2000
:
This Drob-1 induced cell death, however, could not be antagonized by baculovirus
p35 , a broad-spectrum
caspase inhibitor
Shibata et al., J Clin Invest 2000
(Brain Ischemia) :
Using the Cre/loxP system, we have established a transgenic mouse line that selectively expresses
p35 , a broad-spectrum
caspase inhibitor , in OLGs ... Expression of
p35 or elimination of caspase-11
suppressed the
caspase-3 activation and conferred significant protection against hypoxic injury
Xu et al., Brain Res 2001
:
Overexpression of
p35 , a general
caspase inhibitor , also protected PC12 cells from apoptosis
Moretti et al., Proc Natl Acad Sci U S A 2002
:
Adenoviral gene transfer of the caspase inhibitor
p35 in vivo
prevented caspase-3 activation and vMLC1 cleavage, with positive impact on contractility
Fraser et al., EMBO J 1997
:
Caspases are implicated in the execution of apoptosis in Drosophila melanogaster by the observation that expression of baculovirus
p35 , a
caspase inhibitor , blocks cell death in vivo in Drosophila
Zhou et al., Biochemistry 1998
:
We have verified this hypothesis by demonstrating that purified recombinant
p35 inhibits human
caspase-1 , -3, -6, -7, -8, and -10 with kass values from 1.2 x 10 ( 3 ) to 7 x 10 ( 5 ) ( M-1 s-1 ), and with upper limits of Ki values from 0.1 to 9 nM
Okuno et al., J Biol Chem 1998
(Adrenal Gland Neoplasms...) :
In addition, cell death was not inhibited by peptide caspase inhibitors or by expression of
p35 , a baculovirus encoded
caspase inhibitor , indicating that NO-induced cell death was independent of caspases
Izquierdo et al., EMBO J 1999
:
We have produced transgenic mice expressing baculovirus
p35 , a broad-range
caspase inhibitor