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AKT1 — TYR

Text-mined interactions from Literome

Bae et al., J Immunol 2003 : Among the HXYLPM analogues, His-Arg-Tyr-Leu-Pro-Met ( HRYLPM ) activated a broad spectrum of cellular signaling events, including an intracellular Ca ( 2+ ) concentration increase, phosphoinositide 3-kinase, extracellular signal regulated kinase, and Akt activation, however, His-Glu-Tyr-Leu-Pro-Met ( HEYLPM ) activated only intracellular Ca ( 2+ ) concentration and Akt but did not increase Ca ( 2+ )
Fu et al., J Cell Physiol 2006 (Prostatic Neoplasms) : In DU145, Tyr/Phe or Met restriction reduces activity of Akt , mitochondrial distribution of phosphorylated Raf and apoptosis inducing factor ( AIF ), and increases mitochondrial distribution of Bak
Kato et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation) : Our results showed 1 ) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail ( CT ) as well as Akt phosphorylation, 2 ) MUC1 induced Akt phosphorylation required the presence of Tyr ( 20 ) within the PI3K binding motif of the MUC1 CT, and 3 ) mutation of Tyr ( 20 ) or pharmacological inhibition of PI3K activation failed to block MUC1 induced suppression of TLR5 signaling
Nakashima et al., Hypertension 2008 (Hypertrophy) : From these data, we conclude that not only PKC delta kinase activation but also the Src dependent Tyr ( 311 ) phosphorylation contributes to Akt activation and subsequent VSMC hypertrophy induced by Ang II, thus signifying a novel molecular mechanism for enhancement of cardiovascular diseases induced by Ang II
Guillermet-Guibert et al., Proc Natl Acad Sci U S A 2008 : In fibroblasts, which express p110beta but not p110gamma, p110beta mediated Akt activation by the GPCR ligands stromal cell derived factor, sphingosine-1-phosphate, and lysophosphatidic acid but not by the Tyr kinase ligands PDGF, insulin, and insulin-like growth factor 1
Tu et al., J Cell Physiol 2013 (Arthritis, Rheumatoid...) : Transfection of dominant negative Akt or application of PI3K inhibitorLY294002 significantly inhibited p-Tyr705-STAT3 , p-Ser727-STAT3, and PLGF expression, indicating that Akt is involved in JAK3/STAT3/PLGF signaling cascade