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Kinetic of RelA activation controls magnitude of TLR mediated IL-12p40 induction
Kim et al., Int Immunol 2009
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gamma-PGA induced the expression of IL-12p40 , CD80 and CD86 in dendritic cells ( DC ) and macrophages in a Toll-like receptor-4 dependent manner, and the effect of gamma-PGA on T ( h ) 1/T ( h ) 2 development was dependent on the presence of antigen presenting cells (APC)
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Protein tyrosine phosphatase SHP-1 positively regulates TLR induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase